Immune gene diversity and STING1 variants in shaping cancer immunity across different genetic ancestry populations [0.03%]
不同遗传谱系人群中免疫基因多样性和STING1变异体对癌症免疫的影响
Xiaowen Hu,Jie Huang,Jiao Yuan et al.
Xiaowen Hu et al.
As human populations migrated to diverse geographical regions, they encountered varying pathogens, leading to pronounced natural selection pressures on the immune system. Analysis of non-synonymous single-nucleotide polymorphisms (nsSNPs) a...
Hydrogen sulfide persulfidates OAS-A1 to balance cysteine levels in regulating Arabidopsis stomatal development [0.03%]
硫化氢过硫化物OAS-A1调节拟南芥气孔发育中半胱氨酸的平衡
Tong Liu,Zhiwei Zhang,Hao Chen et al.
Tong Liu et al.
Plants regulate photosynthesis and transpiration primarily by adjusting the stomatal aperture and density to adapt to environmental changes. O-acetylserine(thiol)lyase (OAS-TL) maintains a balance between cysteine (Cys) and sulfide metaboli...
Early-life microbiota skews long-term gene expression and chromatin states of bone marrow hematopoietic precursors [0.03%]
生命早期的微生物群会影响骨髓造血前体细胞长期基因表达和染色质状态
Ahmed K Kabil,Alissa Cait,Lisa A Reynolds et al.
Ahmed K Kabil et al.
Early life is a critical window during which the gut microbiota sculpts immunity and long-term susceptibility to allergic disease. Using neonatal antibiotic administration and bone marrow transplantation assays, we show that depletion of sh...
The BZR1-interacting WD repeat protein participates in brassinosteroid-dependent growth and stress response in tomato [0.03%]
番茄BZR1互作的WD重复蛋白参与 brassinosteroid 依赖的生长和胁迫响应
Yue Liu,Xiaole Meng,Chuyong Chen et al.
Yue Liu et al.
Brassinosteroids (BRs) are steroidal phytohormones that play crucial roles in plant growth and resilience. The stability of BRASSINAZOLE RESISTANT 1 (BZR1), the central transcription factor of BR signaling, is controlled by the GSK3-like ki...
Comprehensive identification of the genes involved in the expression of Siglec-15 ligands on osteoclast precursors [0.03%]
全面鉴定参与破骨前体细胞Siglec-15配体表达的基因
Huei-Syuan Jiang,Suh-Yuen Liang,Yu-Chi Chou et al.
Huei-Syuan Jiang et al.
Siglec-15 regulates osteoclast differentiation. The cellular pathways contributing to the expression of Siglec-15 ligand on osteoclast precursors are incompletely understood. We used genome-wide knockout screening to identify genes contribu...
Lactobacillus delbrueckii surface protein P4430 attenuates intestinal inflammation by modulating macrophage polarization via Mincle [0.03%]
乳酸菌表面蛋白P4430通过Mincle调节巨噬细胞极化从而缓解肠炎
Xiangyu Zhang,Xiangyi Zeng,Yujun Wu et al.
Xiangyu Zhang et al.
Ulcerative colitis (UC) is characterized by intestinal inflammation, barrier dysfunction, and dysbiosis, with limited treatment options. Here, we demonstrate that Lactobacillus delbrueckii is commonly reduced in low-birth-weight piglets, de...
Metabolic reprogramming during human neuron differentiation indicates glutaminase as a key determinant in Fragile X syndrome [0.03%]
人类神经元分化过程中的代谢重组表明谷氨酰胺酶是脆性X综合征的关键决定因素
Sneha Shah,Daniel Barnes,Botao Liu et al.
Sneha Shah et al.
Metabolic homeostasis gone awry is a contributor to, if not an underlying cause of, several neurologic disorders. Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by a trinucleotide repeat expansion in FMR1 and consequent lo...
IL-18 produced by pregnant uterus promotes essential inflammatory responses and fetoplacental growth [0.03%]
妊娠子宫产生的IL-18促进必要的炎症反应和胎盘生长
Hajime Ino,Yasuyuki Negishi,Yumi Horii et al.
Hajime Ino et al.
Placental insufficiency affects fetomaternal health throughout life. Although the interaction between the maternal uterine immune milieu and fetus-derived cells plays a crucial role in placental formation, several aspects remain unclear. Th...
H3K27-specific demethylase orchestrates the phenotypic and functional plasticity of intestinal ILC3s [0.03%]
组蛋白特异性脱甲基酶调控肠固有层ILC3的表型和功能可塑性
Xianzhi Gao,Xin Shen,Qianying Xu et al.
Xianzhi Gao et al.
Group 3 innate lymphoid cells (ILC3s) exhibit dynamic plasticity, with their differentiation and function orchestrated by epigenetic mechanisms, including histone modifications and DNA methylation. We identify the histone demethylases UTX a...
Transthyretin-mediated regulation of neuropathic pain and anxiety-like behavior in the lateral parabrachial nucleus [0.03%]
甲状腺转运蛋白介导的外侧延髓旁核神经病理性疼痛和类似焦虑的行为调节作用
Guo-Chuang Deng,Li Liu,Bo-Yang Liu et al.
Guo-Chuang Deng et al.
Neuropathic pain presents a complex challenge in clinical treatment due to its multifaceted etiology and frequent comorbidities with anxiety. Despite its prevalence, the underlying molecular, cellular, and circuit mechanisms remain poorly u...