A coordinated haptic mechanism ensures efficient DNA sampling by the 8-oxoguanine glycosylase OGG1 [0.03%]
一种协调的触觉机制可确保8-氧鸟嘌呤-DNA糖基化酶OGG1高效抽样DNA
Maximilien Martinez,Ostiane D&#x;Augustin,Despoina-Maria Chousianiti et al.
Maximilien Martinez et al.
7,8-Dihydro-8-oxoguanine (8-oxoG), a frequent mutagenic base modification occurring upon oxidative stress, is handled by the DNA glycosylase OGG1 when paired with cytosine, initiating the base excision repair pathway. Since 8-oxoG neither s...
RNA Pol I shapes meiotic chromatin, germline H3K4me3 dynamics, and oogenesis independent of ribosome assembly [0.03%]
RNA聚合酶I通过非核糖体生物发生机制调控生殖细胞染色质、H3K4me3和卵母细胞生成
Raquel Mejia-Trujillo,Qiuxia Zhao,Francesca Abraham et al.
Raquel Mejia-Trujillo et al.
Oogenesis requires extensive chromatin remodeling that primes promoters for embryonic transcription. We reveal a non-canonical role for RNA polymerase I (Pol I) in driving these transitions during Caenorhabditis elegans oogenesis. Using the...
A monoclonal antibody targeting the C-terminal of α-synuclein fibrils mitigates pathology in a Parkinson's disease model [0.03%]
靶向α-突触核蛋白纤维C端的单克隆抗体可缓解帕金森病模型中的病理损害
Shuyi Zeng,Shengnan Zhang,Xun Gui et al.
Shuyi Zeng et al.
Parkinson's disease (PD) pathogenesis is driven by α-synuclein (α-syn) amyloid aggregation, with the flexible C-terminal region mediating pathological interactions with cellular receptors and facilitating disease propagation and neuroinfl...
Hypoxia-inducible factor 1 protects neurons from Sarm1-mediated neurodegeneration [0.03%]
缺氧诱导因子1通过保护神经元免受Sarm1介导的神经退行性病变的影响来延长寿命
Paul Meraner,Adel Avetisyan,Kevin Swift et al.
Paul Meraner et al.
The sterile alpha and TIR motif-containing 1 (Sarm1) NAD+ hydrolase drives neurodegeneration, but how Sarm1 activity is regulated remains poorly defined. Using CRISPR-Cas9 screening, we found that loss of Vhl suppressed Sarm1-mediated cellu...
Extracellular matrix stiffness drives post-mitotic nuclear pore complex assembly to promote neuroblastoma pathogenesis [0.03%]
细胞外基质刚性通过促进有丝分裂后核孔复合体组装来促进神经母细胞瘤的发生发展
Guo-Zhu Sun,Chen Miao,Wen-Hao Tian et al.
Guo-Zhu Sun et al.
Nuclear pore complex (NPC) undergoes dynamic changes in physiology and pathology, yet its roles in neuroblastoma (NB) remain unclear. We demonstrated that rigid extracellular matrix (ECM) facilitated NPC-mediated nucleocytoplasmic transport...
HP1γ self-assembles and cooperates with KAP1 in repression of long noncoding RNA AI662270 in ESCs [0.03%]
HP1γ通过自聚集与KAP1合作在多能干细胞中抑制长非编码RNA AI662270的转录
Nitika Gaurav,Weihua Qin,Karthik Selvam et al.
Nitika Gaurav et al.
HP1s are involved in the assembly of heterochromatin and transcriptional regulation. Here, we report the molecular mechanisms underlying binding of the chromoshadow domain of HP1γ (HP1γCSD) to the transcriptional co-repressor KAP1 and HP1...
Berent Aldikacti,Hidayet Putun,Vishal Sarsani et al.
Berent Aldikacti et al.
Protein quality control (PQC) systems are essential for cellular resilience to proteotoxic stress. Despite intensive study, functional redundancies in the system obscure the contributions of important individual genes. Here, we leverage tra...
A positive feedback loop between FGR and p65 sustains satellite glial cell activation and chronic neuropathic pain [0.03%]
FGR与p65之间的正反馈循环维持卫星神经胶质细胞激活和慢性神经病理性疼痛
Yangyuxin Huang,Yanni He,Zanbing Wang et al.
Yangyuxin Huang et al.
Chronic neuropathic pain is a debilitating clinical problem. Sustained activation of satellite glial cells (SGCs) in the dorsal root ganglion (DRG) contributes to neuroinflammation and persistent pain, although the underlying mechanisms dri...
Construction of individual-specific social cognitive maps in the human brain [0.03%]
人脑中个体特异性社会认知地图的构建
Tianyu Gao,Yiwen Deng,Shihui Han
Tianyu Gao
Social interactions depend on social cognitive maps (SCMs) in the brain. We investigate how SCMs emerge during partner selection based on trial-by-trial feedback about candidates' generosity and competence. We show that the candidates sprea...
Tumor-derived aminopeptidase N promotes early stages of brain metastatic colonization [0.03%]
肿瘤衍生的氨肽酶N促进脑转移早期定植阶段的发展
Leire Bejarano,Alberto Hernández-Barranco,Vincent Roh et al.
Leire Bejarano et al.
Metastasis is a highly inefficient process, with the vast majority of disseminated cancer cells failing to form secondary tumors. To establish brain metastases, cancer cells must traverse the blood-brain barrier and rapidly adapt to the spe...