A monoclonal antibody targeting the C-terminal of α-synuclein fibrils mitigates pathology in a Parkinson's disease model
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Parkinson's disease (PD) pathogenesis is driven by α-synuclein (α-syn) amyloid aggregation, with the flexible C-terminal region mediating pathological interactions with cellular receptors and facilitating disease propagation and neuroinflammation. Through i... ...
