SNAP25 undergoes phase separation to facilitate the assembly of the synaptic vesicle fusion machinery [0.03%]
SNAP25经历相分离以促进突触囊泡融合装置的组装
Min Zhu,Yulei Jin,Jintong Liu et al.
Min Zhu et al.
The assembly of the SNARE complexes drives synaptic exocytosis in neurotransmission. SNAP25 is a key SNARE protein that pairs with syntaxin-1 and VAMP2 in synaptic vesicle fusion. The dysfunction of SNAP25 is associated with neurodevelopmen...
Tfam-mediated metabolic perturbation in RORγt+ lymphocytes impacts intestinal tissue homeostasis and promotes GATA3+RORγt+ innate lymphoid cells [0.03%]
TFAM介导的效应淋巴细胞代谢紊乱影响肠道组织稳态并促进GATA3+RORγt+固有淋巴样细胞产生
Na Sun,Rupam Paul,Eric Y Helm et al.
Na Sun et al.
Rorc-mediated deletion of Tfam, a mitochondrial transcription factor, causes tuft cell and type 2 immunity-driven small intestine (SI) lengthening in mice. Here, we report an indispensable role for T helper 2 (Th2) cells in this process. Hi...
A CRISPR-based mitochondrial gene therapy tool derived by engineering guide RNAs [0.03%]
一种基于CRISPR的线粒体基因治疗工具：通过工程引物RNA进行改造获得
Ying Wang,Xinwan Su,Yu Chen et al.
Ying Wang et al.
Mitochondrial genetic diseases arise from mitochondrial DNA (mtDNA) defects, which gene therapy tools may rectify. However, delivering single-guide RNAs (sgRNAs) into mitochondria remains a challenge limiting CRISPR-mediated mtDNA therapy. ...
MARK2 serves as a key regulator of host antiviral immunity through GEF-H1 phosphorylation [0.03%]
MARK2通过GEF-H1磷酸化在宿主抗病毒免疫中起关键调节作用
Kezhen Wang,Linchao Li,Yanan Li et al.
Kezhen Wang et al.
The innate immune system detects viral infections and mounts robust type I interferon (IFN-I) responses to establish antiviral defenses. However, the regulatory mechanisms that control the amplitude and duration of IFN-I signaling remain in...
RAB3GAP2 is a regulator of skeletal muscle endothelial cell proliferation and associated with capillary-to-fiber ratio [0.03%]
RAB3GAP2调节骨骼肌内皮细胞增殖并与毛细血管-肌纤维比率相关
Kristoffer Ström,Nikolay Oskolkov,Tugce Karaderi et al.
Kristoffer Ström et al.
Skeletal muscle capillary density is correlated with physical performance and whole-body metabolic properties. Thus, we performed a genome-wide association study of skeletal muscle capillary-to-fiber ratio (C:F) (n = 603 males) and found th...
Triglycerides induce endoplasmic reticulum lipid bilayer stress to activate PERK and enhance antifungal immunity [0.03%]
甘油三酯通过诱导内质网脂双层应力激活PERK并增强抗真菌免疫反应
Han Wu,Qing Shui,Xiaoxi Luan et al.
Han Wu et al.
Invasive fungal infections remain a major clinical challenge due to limited antifungal drugs, drug toxicity, and resistance. Fungal infections trigger endoplasmic reticulum (ER) stress. However, the mechanism through which this stress respo...
Cellular Mg2+ decrease causes a distinctive NF-κB-dependent form of cell death [0.03%]
细胞内Mg2+浓度下降引起的一种独特的NF-κB依赖性的细胞死亡形式
Koyuki Kawamura,Koya Ono,Eikan Mishima et al.
Koyuki Kawamura et al.
Mg2+ is an essential cofactor for numerous enzymes, supporting fundamental cellular processes. The phosphatase of regenerating liver (PRL) protein family, frequently upregulated in cancer, inhibits cyclin M (CNNM) Mg2+ efflux transporters. ...
Humanization and engineering of protective antibodies targeting severe fever with thrombocytopenia syndrome virus Gn protein [0.03%]
人细小神经症病毒Gn蛋白保护性抗体的人工进化研究
Xuanxiu Ren,Wei Deng,Feiyang Yu et al.
Xuanxiu Ren et al.
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a highly lethal tick-borne bunyavirus with no approved therapies. We previously developed a murine-human chimeric antibody S2A5, which provides complete protection against lethal ...
Porcine IRF2 suppresses the cGAS-STING-mediated antiviral IFN signaling by competing IRF3 for binding to the IFN promoter [0.03%]
猪IRF2通过竞争IRF3与干扰素启动子的结合来抑制cGAS-STING介导的抗病毒I型干扰素信号通路
Sen Jiang,Jingyu He,Kun Wang et al.
Sen Jiang et al.
The innate immune cGAS-STING-IRF3-IFN signaling pathway plays a crucial role in host antiviral defense. While mammalian IRF families encompass IRF1 through IRF9, the involvement of IRF members other than IRF3 in cGAS-STING antiviral signali...
Ptprf is the conserved receptor for Asprosin's glucogenic effects in vertebrates [0.03%]
Ptprf是脊椎动物中asprosin升糖作用的保守受体
Zhiquan Liu,Pengyu Wang,Yixuan Hu et al.
Zhiquan Liu et al.
Asprosin, a fasting-induced glucogenic hormone, plays a crucial role in maintaining glucose homeostasis; however, its receptor remains elusive. This study identifies protein tyrosine phosphatase receptor F (Ptprf) as the receptor mediating ...