Compound amino acid synergizes ceftazidime-avibactam to eradicate extracellular and facultative intracellular MDR pathogens [0.03%]
复合氨基酸与头孢他啶-阿维巴坦联合用药可清除胞外及兼性胞内多重耐药病原体
Jiao Xiang,Yu-Qing Zhou,Si-Chen Yuan et al.
Jiao Xiang et al.
With the rise in antibiotic-resistant infections, enhancing the efficacy of currently available antibiotics is crucial to address this crisis. In this study, we demonstrate that the clinically approved amino acid formulation 18AA (18 amino ...
Insulin and adipocyte IRF4 promote fat retention over muscle preservation during intermittent fasting in obesity [0.03%]
肥胖症患者在间歇性禁食期间胰岛素和脂肪细胞IRF4促进脂肪积累超过肌肉保存
Daniel M Marko,Meghan O Conn,Joseph F Cavallari et al.
Daniel M Marko et al.
Intermittent fasting (IF) can lower body mass during obesity, but it is unknown why certain individuals lose less fat and more lean mass during IF. We hypothesized that hyperinsulinemia and an insulin-responsive adipocyte factor regulate th...
Clec16a maintains definitive hematopoietic stem and progenitor cells via mitophagy [0.03%]
Clec16a通过线粒体自噬维持定性和祖细胞
Shuyang Cai,Qian Zhang,Qian Luo et al.
Shuyang Cai et al.
Hematopoietic stem and progenitor cells (HSPCs) arise from hemogenic endothelium via the endothelial-to-hematopoietic transition (EHT), a process requiring precise mitochondrial quality control. Here, we identify Clec16a, an E3 ubiquitin li...
Small-molecule enhancement of METTL3 S-palmitoylation as a therapeutic strategy for osteoarthritis [0.03%]
小分子增强METTL3的S-棕榈酰化作为治疗骨关节炎的策略
Wei Qin,Jiatian Wei,Fuxi Li et al.
Wei Qin et al.
METTL3, a key RNA N6-methyladenosine (m6A) methyltransferase, plays essential roles in cell fate regulation and tissue homeostasis, yet therapeutic strategies to enhance its activity remain unexplored. Here, we profile the S-palmitoylation ...
Evolutionary-guided advanced deep-learning architecture powers mammalian GPCRome agonist predictions [0.03%]
基于进化引导的先进深度学习架构赋能哺乳动物GPCRome激动剂预测
Aayushi Mittal,Mudit Gupta,Sanjay Kumar Mohanty et al.
Aayushi Mittal et al.
G-protein-coupled receptors constitute a highly conserved superfamily that orchestrates essential signaling processes across species. Contemporary computational approaches for predicting ligand-receptor interactions are hindered by restrict...
Alia Sajani,Evelien Schaafsma,Walburga Croteau et al.
Alia Sajani et al.
This study describes the transcriptional heterogeneity of murine and human naive CD4+ T cells as comprising multiple discrete clusters that impact CD4+ T cell fate and trajectories. Naive CD4+ T cells experiencing inflammatory environments ...
In utero exposure to NMDA receptor autoantibodies disrupts hippocampal circuit maturation [0.03%]
宫内接触N-甲基-D天冬氨酸受体自身抗体可干扰海马电路成熟
Myrtill Majoros,Chuanqiang Zhang,Vahid Rahmati et al.
Myrtill Majoros et al.
Maternal anti-neuronal autoantibodies (ABs) have been linked to abnormal brain maturation and may increase the risk of neurodevelopmental disorders, yet their pathogenetic mechanisms remain elusive. Here, we show that in utero exposure to A...
Juken Hong,Wenzhi Xue,Teng Wang
Juken Hong
Bimodality-the coexistence of two peaks in trait distributions-is common in natural ecosystems. In microbiomes, bimodality of species abundances is known. However, whether this pattern applies to community functionality remains unclear. Her...
Glomerular basement membrane structural integrity dictates trans-tissue deposition of laminin in the kidney [0.03%]
肾小球基底膜结构完整性决定层粘连蛋白跨组织沉积
Kohei Omachi,Meei-Hua Lin,Pongpratch Puapatanakul et al.
Kohei Omachi et al.
Basement membranes (BMs) are specialized extracellular matrices (ECMs) essential for tissue structure and function. In non-vertebrates, ECM components can be produced both locally and by distant tissues. In contrast, mammalian ECM has tradi...
Glutamine metabolism tunes myeloid responses to drive resolution of inflammation during skin repair [0.03%]
谷氨酰胺代谢调节髓系细胞反应以促进皮肤修复过程中的炎症消退
Yiting Xu,Maria Fernanda Forni,Abigail Benvie et al.
Yiting Xu et al.
Tissue repair requires inflammation resolution, but the molecular mechanisms involved in vivo are not fully understood. Here, we show that glutamine metabolism suppresses neutrophil recruitment to abrogate inflammation and drive skin wound ...