Sabrina Z Wang,J Payton Timken,Ellen S Hong et al.
Sabrina Z Wang et al.
Glioblastoma (GBM) remains a lethal tumor, largely due to robust mechanisms that prevent effective induction of cell death. Ferroptosis, a form of iron-dependent cell death, is a promising vulnerability in GBM. Here, we demonstrate that lip...
Unveiling the epitope repertoires and protective roles of MERS-CoV-specific T cells in mice [0.03%]
揭示MERS-CoV特异性T细胞在小鼠中的表位谱系和保护作用
Zhen Zhuang,Jiaying Luo,Guoxian Zhang et al.
Zhen Zhuang et al.
Since its initial emergence in 2012, MERS-CoV has remained endemic and a global health threat. While accessory proteins (ORFs) are known for immune evasion, their role in adaptive immunity is unexplored. This study systematically investigat...
Haplotype-resolved genome of hexaploid Solanum nigrum: Insights into origin, evolution, and steroidal glycoalkaloid biosynthesis [0.03%]
六倍体毒芹的单体型基因组解析：起源、进化及甾类甘酰甜菜碱生物合成的新见解
Bo Kong,Xiaoxu Li,Zhenchen Zhang et al.
Bo Kong et al.
Black nightshade (Solanum nigrum) is a valuable medicinal plant and emerging model for polyploid evolution, but its study is limited by the lack of a reference genome due to complex polyploidy. We present the first haplotype-resolved, chrom...
Metabolic reinvigoration of NK cells by IL-21 enhances immunotherapy against MHC class I-deficient solid tumors [0.03%]
IL-21通过代谢重塑NK细胞增强对抗MHC I类分子缺失的实体肿瘤免疫治疗效应
Yi Wang,Chao Huang,Guoxin Cai et al.
Yi Wang et al.
Natural killer (NK) cells, a type of potent cytotoxic lymphocyte, are particularly promising for the treatment of cancers that lose or downregulate major histocompatibility complex class I (MHC class I) expression to evade T cell-mediated i...
Thomas Bjarnsholt,Claus Lex,Phil Stewart
Thomas Bjarnsholt
Biofilms have profoundly shaped our understanding of chronic infection, yet their explanatory reach is limited. This commentary argues that chronicity emerges from a host-pathogen partnership, where host-derived structural, metabolic, immun...
Divergent Roles of PI3K Isoforms in PTEN-Deficient Glioblastomas [0.03%]
PTEN缺陷型胶质母细胞瘤中PI3K各异构体的分化作用
Shaozhen Xie,Jing Ni,J Ricardo McFaline-Figueroa et al.
Shaozhen Xie et al.
Published Erratum
Cell reports. 2026 Feb 26;45(3):117127. DOI:10.1016/j.celrep.2026.117127 2026
CPSF73 activation and 3' RNA polymerase II pausing are lost during readthrough transcription after heat shock [0.03%]
热休克后的通读转录中，CPSF73激活和RNA聚合酶II的3'端暂停丢失
Kaitlyn E Walsh,James A Goodrich,Jennifer F Kugel
Kaitlyn E Walsh
Environmental stresses induce RNA polymerase II (Pol II) to read through normal termination sites at mRNA genes using unknown mechanisms. We observe strong readthrough transcription downstream of thousands of genes after heat shock. Additio...
Human superior colliculus pathways represent the form and motion of looming objects [0.03%]
人脑上丘通路表征迫近物体的形态和运动状态
Monica K Thieu,Meera Sethi,Elias Aberman et al.
Monica K Thieu et al.
The superior colliculus is a conserved midbrain structure critical for detecting and responding to threats, yet its role in human cognition and emotion remains poorly understood. Using task-based fMRI and computational modeling in two exper...
RNase L regulates the antiviral proteome by accelerating mRNA decay, inhibiting nuclear mRNA export, and repressing transcription [0.03%]
RNase L通过加速mRNA降解、抑制核内mRNA输出和抑制转录来调控抗病毒蛋白组
J Monty Watkins,Cameron J Douglas,Renee Cusic et al.
J Monty Watkins et al.
Ribonuclease L (RNase L) is an antiviral endoribonuclease that triggers widespread degradation of cellular mRNAs. Here, we show that RNase L-mediated decay of cellular mRNA is a conserved response to flaviviruses, including Zika virus (ZIKV...
Nonsense-mediated mRNA decay orchestrates neuronal migration and cortical lamination while modulating Reelin and ciliary gene regulatory networks [0.03%]
nonsense介导的mRNA衰减通过调节Reelin和纤毛基因调控网络来协调神经元迁移和皮质层形成
Lin Lin,Naoto Kubota,Yi-Li Lam et al.
Lin Lin et al.
Nonsense-mediated mRNA decay (NMD) is associated with neurodevelopmental disorders, yet its role in cortical organization is unknown. We demonstrate that NMD mediated by UPF2 is indispensable for cortical organization. Conditional deletion ...