Nucleic acid-induced NADase activation of a short Sir2-associated prokaryotic Argonaute system [0.03%]
核酸诱导的NAD酶激活与短Sir2相关原核Argonaute系统的相互作用
Dapeng Sun,Kaixiang Zhu,Linyue Wang et al.
Dapeng Sun et al.
Published Erratum
Cell reports. 2026 Mar 7;45(3):117172. DOI:10.1016/j.celrep.2026.117172 2026
Latexin regulates sex dimorphism in hematopoiesis via gender-specific differential expression of microRNA 98-3p and thrombospondin 1 [0.03%]
Latexin通过性别特异性差异表达的microRNA 98-3p和血小板源性生长因子受体相互作用蛋白THBS1调节造血系统的性别二态性
Xiaojing Cui,Cuiping Zhang,Fang Wang et al.
Xiaojing Cui et al.
Published Erratum
Cell reports. 2026 Mar 6;45(3):117153. DOI:10.1016/j.celrep.2026.117153 2026
Genetically engineered eye-colonizing microbes that deliver the anti-inflammatory cytokine interleukin-10 enhance corneal tissue repair [0.03%]
基因工程眼定植微生物递送抗炎细胞因子白介素-10可增强角膜组织修复
Jackie Shane,Matthew Evans,Yannis Rigas et al.
Jackie Shane et al.
Barrier surfaces harbor tissue-colonizing microbes that can shape local physiology and immunity. During corneal injury, inflammation can delay healing, resulting in loss of visual acuity. Standards of care include topical applications of th...
Victoria Xu,Aiysha McInnes,Matthew Wake et al.
Victoria Xu et al.
Adeno-associated viruses (AAVs) are parvoviruses utilized as gene therapy vectors. However, the AAV packaging mechanism is unresolved at the molecular level, creating a bottleneck for vector manufacturing, safety, and efficacy. Here, cryo-E...
IgE-dependent anaphylaxis is regulated by sphingolipid binding to activating and inhibitory CD300 family members [0.03%]
免疫球蛋白E依赖的过敏反应通过鞘脂结合活化型和抑制型CD300成员进行调控
Kumi Izawa,Ayako Kaitani,Yutaka Enomoto et al.
Kumi Izawa et al.
Immunoglobulin E (IgE)-dependent mast cell degranulation and anaphylaxis are suppressed by the CD300f-ceramide interaction. However, the related, positive regulatory mechanisms remain unclear. Here, we examine the effect of FcεRIγ-coupled...
Functionally distinct ALK and ROS1 fusions detected in infant-type hemispheric gliomas converge on STAT3 and SHP2 activation [0.03%]
功能上不同的ALK和ROS1融合在婴儿型半球胶质瘤中被检测到，共同作用于STAT3和SHP2激活
Andreas Postlmayr,Astrid Sanchez Bergman,Jacob Torrejon Diaz et al.
Andreas Postlmayr et al.
ALK and ROS1 fusions are key drivers of infant-type hemispheric gliomas (IHG). With diverse gene partners, the impact of ALK and ROS1 oncoprotein heterogeneity on glioma biology remains unknown. We developed an integrative phospho-proteomic...
APC coordinates GSK3 phosphorylation of SETD8 to suppress colorectal cancer [0.03%]
APC通过GSK3介导的SETD8磷酸化抑制结直肠癌发生发展
Zvi Cramer,Keara Monaghan,Ricardo Petroni et al.
Zvi Cramer et al.
Colorectal cancer (CRC) is the second-leading cause of cancer-related deaths. Mutations in the tumor-suppressor APC initiate CRC in part by preventing the glycogen synthase kinase 3 (GSK3) kinase from phosphorylating β-CATENIN, leading to ...
A tumor-resident bacterium promotes cervical cancer progression through lysoPC-mediated c-Jun/c-Fos activation [0.03%]
一种定植于肿瘤中的细菌通过lysoPC介导的c-Jun/c-Fos活化促进宫颈癌进展
Chao Li,Han Zhao,Jingjing Wang et al.
Chao Li et al.
Tumor-resident microbiota are identified as a critical modulator in the carcinogenesis and progression of cervical malignancies. However, the mechanisms linking these microbiota to cervical cancer remain poorly understood. In this study, we...
Evan J Morrison,Olivia S Rissland
Evan J Morrison
Published Erratum
Cell reports. 2026 Mar 5;45(3):117111. DOI:10.1016/j.celrep.2026.117111 2026
Large adipocytes increase vesicle-mediated lipid release and promote breast cancer malignancy [0.03%]
大型脂肪细胞增加囊泡介导的脂质释放并促进乳腺癌恶性肿瘤的发展
Garrett F Beeghly,Irina Kopyeva,Jenny Deng et al.
Garrett F Beeghly et al.
Primary adipocytes exhibit striking variability in size, yet the functional consequences of adipocyte hypertrophy remain unclear due to insufficient experimental approaches to control for cell size. Here, we establish methods to culture lar...