Similar destabilization of neural dynamics under different general anesthetics [0.03%]
不同的全麻药物对神经动力学的破坏效果相似
Adam J Eisen,Alexandra G Bardon,Jesus J Ballesteros et al.
Adam J Eisen et al.
Different classes of anesthetics induce unconsciousness despite acting through distinct molecular mechanisms, raising the possibility that their convergent effects arise at the level of the dynamics of neural population activity. To explore...
Developmental reprogramming underlies chemotherapy resistance in favorable-histology Wilms tumor [0.03%]
发育重编程导致良好组织分型的威斯科特-阿尔拉氏瘤对化疗耐药性
Andrew M Fleming,Carolyn M Jablonowski,Hongjian Jin et al.
Andrew M Fleming et al.
Children with favorable-histology Wilms tumor (FHWT) who relapse or whose tumors show blastemal predominance post-chemotherapy often face poor outcomes. The purpose of this study is to identify mechanisms of chemotherapy resistance in FHWT....
Alanine catabolism as a targetable vulnerability for MYC-driven liver cancer [0.03%]
靶向甲硫氨酸驱动型肝癌的生化代谢弱点：丙氨酸分解代谢
Tonatiuh Montoya,Joyce V Lee,Longhui Qiu et al.
Tonatiuh Montoya et al.
Liver cancer is a leading cause of cancer-related death due to the shortage of effective therapies, and MYC overexpression defines an aggressive and difficult-to-treat subset of patients. Given MYC's ability to reprogram cancer metabolism a...
A single-cell CRISPR screen defines a gene regulatory network governing human pluripotency in primed and naive cells [0.03%]
单细胞CRISPR筛选定义了调控人类多能性的基因调控网络（滋养层和naive细胞）
Gal Keshet,Nissim Benvenisty
Gal Keshet
Human pluripotent stem cells (hPSCs) can self-renew indefinitely and differentiate into all three embryonic germ layers. We previously defined the essentialome of hPSCs using a genome-wide CRISPR screen, but the functions of each gene remai...
Coordinated parieto-frontal neuronal communication is critical for abstract quantity judgments in primates [0.03%]
抽象数量判断的神经机制：顶叶和前额叶的协同作用
Tobias Machts,Andreas Nieder
Tobias Machts
Accurate numerical cognition relies on representing and comparing quantities, a fundamental skill for adaptive behavior. In nonhuman primates, the parieto-frontal network, including the ventral intraparietal area (VIP) and prefrontal cortex...
Dexmedetomidine inhibits fear memory consolidation via the astrocyte-specific Srebf1-Phgdh pathway in the prelimbic prefrontal cortex [0.03%]
右美托咪啶通过星形胶质细胞特异性Srebf1-Phgdh信号通路抑制前额叶皮层中介导的恐惧记忆巩固作用
Ke Li,Wei Wei,Feiyang Zhang et al.
Ke Li et al.
Post-traumatic stress disorder (PTSD) develops following exposure to a traumatic event. However, effective prevention and treatments remain elusive. In this study, we report that sub-anesthetic doses of dexmedetomidine can alleviate fear in...
Calmodulin-like protein condensates decode PAMP-induced nuclear calcium to activate plant immunity [0.03%]
钙调素样蛋白凝聚物解码模式触发的核内钙信号以激活植物免疫反应
Weiping Mo,Zhuo Liu,Xiaoyang Zhang et al.
Weiping Mo et al.
Calcium signatures are key responses to diverse environmental stresses, yet how distinct calcium signals within confined subcellular compartments are decoded remains poorly understood. Calmodulin proteins, serving as canonical calcium senso...
Enhanced HIF-1α cooperation by a human RORγt mutant potentiates Th17 pathogenicity [0.03%]
人类RORγt突变体通过增强HIF-1α协同作用提高Th17致病性
Peixian Dong,Liang Liu,John Yu et al.
Peixian Dong et al.
T helper 17 (Th17) cells are pivotal in mucosal defense and autoimmune pathology, with their function governed by the transcription factor retinoic acid receptor-related orphan receptor gamma t (RORγt). Although genome-wide association stu...
Comprehensive profiling of skin microbiome diversity and major determinants in a multi-regional Chinese population [0.03%]
中国多地区人群皮肤微生物组多样性和主要决定因素的全面特征分析
Wan-Xue Zhang,Juan Du,Linpei Dong et al.
Wan-Xue Zhang et al.
The human skin microbiome is essential for health and is shaped by both host and environmental factors. To establish a nationwide baseline, we profile the skin microbiome of 1,029 Chinese individuals across three body sites (hand, axilla, a...
Loss of p53 exacerbates autoimmunity by reprogramming propionyl-CoA metabolism and histone modifications in Treg cells [0.03%]
p53丢失通过重新编程Tregs细胞中的丙酸辅酶a代谢和组蛋白修饰加剧自身免疫反应
Siyi Xie,Taiqi Chen,Linfeng Li et al.
Siyi Xie et al.
Metabolic regulation is central to the tumor suppressor function of p53. By analyzing the human patients with autoimmune diseases, we found that p53 expression was significantly reduced in Treg cells, negatively correlating with abnormally ...