A single-cell CRISPR screen defines a gene regulatory network governing human pluripotency in primed and naive cells
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Human pluripotent stem cells (hPSCs) can self-renew indefinitely and differentiate into all three embryonic germ layers. We previously defined the essentialome of hPSCs using a genome-wide CRISPR screen, but the functions of each gene remain obscure. Here, we ... ...
