Nutrient stress activates RAB5B-mediated autophagy to remodel the synaptic proteome [0.03%]
营养压力激活RAB5B介导的自噬以重塑突触蛋白组学
Melina Overhoff,Lotte Ickert,Sebastian Marten et al.
Melina Overhoff et al.
Synaptic proteostasis is crucial for neuronal function, yet how synapses adapt to metabolic stress remains unclear. We show that nutrient stress, particularly serum withdrawal, induces autophagy-dependent remodeling of the synaptic proteome...
SLC39A11 mediates intracellular manganese partitioning and adaptive iron transport [0.03%]
SLC39A11介导细胞内锰的分布和适应性铁转运
Yanmei Cui,Fan Du,Juan Wang et al.
Yanmei Cui et al.
Zrt/Irt-like protein (ZIP) family members typically mediate zinc transport into the cytoplasm. Here, we characterize SLC39A11(ZIP11)-an evolutionarily conserved ZIP homologous to Escherichia coli metal ZupT-revealing its context-dependent r...
Circulating memory-phenotype CD4+ T cells rapidly accumulate in the ischemic gut to exacerbate tissue injury in an innate manner [0.03%]
循环记忆表型CD4+T细胞迅速在缺血性肠道中积累，并以固有免疫的方式加重组织损伤
Kosuke Sato,Shunichi Tayama,Akihisa Kawajiri et al.
Kosuke Sato et al.
Memory-phenotype (MP) CD4+ T lymphocytes develop from peripheral naive precursors via self-recognition at homeostasis. While MP cells exert innate immune function in infectious and autoimmune contexts, their functional significance in ische...
Retraction Notice to "A light-responsive transcriptional circuit suppresses sexual reproduction in the rice blast fungus in the field" [Cell Reports 45 (2026) 117038] [0.03%]
有关“光响应转录电路抑制水稻稻瘟病菌田间有性生殖”的撤稿声明[《细胞报告》第45卷(2026年)117038号文章]
Hao Liang,Penghui Zhang,Run Gao et al.
Hao Liang et al.
Intermembrane coupling between Bcl-xL and the IP3 receptor supports local Ca2+ transfer at ER-mitochondrial contacts [0.03%]
Bcl-xL与IP3受体之间的跨膜偶联可支持内质网-线粒体接触点处的局部钙转移
Arijita Ghosh,David Weaver,Chi Li et al.
Arijita Ghosh et al.
Bcl-xL, an anti-apoptotic Bcl-2 family protein, engages laterally with Bak/Bax in the outer mitochondrial membrane (OMM) to inhibit apoptosis and interacts with the IP3 receptor Ca2+ channels (IP3Rs) in the endoplasmic reticulum (ER) membra...
Deep learning segmentation with curvature consistency reveals astrocyte nanostructure across species [0.03%]
基于曲率一致性的深度学习分割法揭示了不同物种中星形胶质细胞的纳米结构
Albert Hiu Ka Fok,Yanan Wang,Megan Ng et al.
Albert Hiu Ka Fok et al.
Cellular function depends on the precise deployment and distribution of nanoscale structures, but these features remain difficult to measure and compare between cells and datasets. This challenge is pronounced for astrocytes, whose intricat...
A single-cell transcriptomic atlas identifies hierarchical skeletal progenitors and zonal patterning in mouse mandibular cartilage [0.03%]
小鼠下颌软骨单细胞转录组图谱揭示了骨骼祖细胞的层次结构和区域模式
Ikue Tosa,Wakana Kitagawa,Benjamin Kheyfets et al.
Ikue Tosa et al.
Skeletal and synovial joint development involves distinct skeletal stem/progenitor populations. However, in neural crest-derived temporomandibular joint (TMJ), skeletal stem/progenitor lineage dynamics and ossification programs remain poorl...
Notch2 signaling instructs viral and bacterial TLR responsiveness in B cells [0.03%]
诺特定点信号传导使B细胞具有对病毒和细菌TLR反应的能力
Jennifer Londregan,Isaiah Rozich,Brian T Gaudette et al.
Jennifer Londregan et al.
Marginal zone (MZ) B cells optimize protection against blood-borne bacteria by rapidly producing plasma cells in response to Toll-like receptor (TLR) ligands. Here, we demonstrate that Notch2 instructs this responsiveness for both the dsRNA...
CCR5 drives glucose metabolic reprogramming to control microglial synaptic pruning via histone lactylation in a mouse model of depression [0.03%]
CCR5通过组蛋白乳酸化在抑郁小鼠模型中控制小胶质细胞突触修剪的葡萄糖代谢重编程
Ying-Ying Jiao,Zhu Zhu,Rui-An Wang et al.
Ying-Ying Jiao et al.
Depression is linked to microglial activation, but the precise triggers and downstream pathways remain elusive. Through single-cell RNA sequencing of human blood samples, we find upregulation of the CCL5-CCR5 axis in patients with major dep...
B7-H3/CD276-specific nanobody T3CL11 enables tumor imaging in murine osteosarcoma and colorectal cancer models [0.03%]
特异结合B7-H3/CD276的纳米抗体T3CL11能够用于小鼠骨肉瘤和结直肠癌模型中的肿瘤成像
Wei Min Chen,Srujana Kishore,Vaibavi Srirangam Ramanujam et al.
Wei Min Chen et al.
Members of the B7 receptor family regulate immune responses and tumor progression. B7-H3 (CD276) is highly expressed in many solid tumors, where it suppresses immune surveillance and is associated with poor clinical prognosis, making it an ...