Arun K Shukla
Arun K Shukla
Cell Reports spoke with Arun K. Shukla about his scientific career, work in his lab, his mentorship experience, and the interconnectedness of science. Co...
Hormetic fasting extends Caenorhabditis elegans lifespan via H3K27 acetylation of lipid catabolism and antioxidant genes [0.03%]
hormetic 禁食通过脂质分解和抗氧化基因的H3K27乙酰化延长线虫寿命
Yifei Zhou,Fasih M Ahsan,Sainan Li et al.
Yifei Zhou et al.
Exposure to low levels of environmental challenges, known as hormetic stress, fosters subsequent stress resistance and promotes healthy aging in later life. However, specific mechanisms governing transcriptional reprogramming upon hormetic ...
Cholesterol transfer proteins promote Atg-independent ER clearance by lysosomes [0.03%]
胆固醇转移蛋白通过自噬非依赖方式促进内质网的溶酶体清除作用
Ruoxi Wang,Tina M Fortier,Xiaofeng Sun et al.
Ruoxi Wang et al.
Selective removal of endoplasmic reticulum (ER) is important for cell health. Macroautophagy is the primary mechanism for the removal of the ER, but the ER can be cleared in a macroautophagy-independent manner. However, the physiological re...
The hepatitis E virus capsid protein forms amyloid-like fibrils that sequester TANK-binding kinase 1 to dampen antiviral responses [0.03%]
乙肝病毒感染干扰抗病毒免疫反应的新机制
Paula Jordan,Jungen Hu,Giulia Mizzon et al.
Paula Jordan et al.
Hepatitis E virus (HEV) is the leading cause of viral hepatitis worldwide. We find that the HEV ORF2 capsid protein contains intrinsically disordered regions (IDRs) at its N terminus that promote condensate formation through liquid-liquid p...
SLC22A3/OCT3 drives serotonin-mediated stemness in pancreatic cancer [0.03%]
SLC22A3/OCT3通过血清素介导的干细胞特性调控胰腺癌干细胞属性
Nivedeta Krishna Kumar,Venkatesh Varadharaj,Neelanjana Gayen et al.
Nivedeta Krishna Kumar et al.
Pancreatic cancer (PC) is a highly aggressive malignancy, with cancer stem cells (CSCs) playing a critical role in metastasis, therapy resistance, and recurrence, thereby presenting significant treatment challenges. Emerging evidence sugges...
Poising and connectivity of emergent human developmental enhancers in the transition from naive to primed pluripotency [0.03%]
胚胎从 naïve 向 pre-implantation 前过渡过程中人类原性态基因组的开启及连接状态变化分析
Marina C Nocente,Monica Della Rosa,Andrew A Malcolm et al.
Marina C Nocente et al.
Poised enhancers (PEs), co-marked by H3K4me1 and Polycomb-associated H3K27me3, are common in primed human pluripotent stem cells (hPSCs) resembling post-implantation epiblast but scarce in naive hPSCs modeling pre-implantation epiblast. PEs...
Impaired spatial coding and neuronal hyperactivity in the medial entorhinal cortex of aged APP knock-in mice [0.03%]
APP敲入小鼠内侧齿状回空间编码缺陷和神经元高反应性
Gustavo A Rodriguez,Andrew Aoun,Eva F Rothenberg et al.
Gustavo A Rodriguez et al.
Advanced amyloid beta (Aβ) pathology is associated with aberrant neuronal network activity and cognitive impairment in preclinical Alzheimer's disease (AD) models. Here, we assess Aβ pathology's impact on spatial information processing in...
A cross-vertebrate brain protein interaction map identifies conserved neural and non-neural complexes [0.03%]
跨脊椎动物脑蛋白相互作用图鉴识出保守的神经和非神经复合物
Vy Dang,Brittney Voigt,David Yang et al.
Vy Dang et al.
Protein-protein interactions underlie core brain functions, including neurotransmitter release, receptor activation, and intracellular signaling. Here, we present a compendium of protein-protein interactions conserved across vertebrate brai...
Dana Klatt Shaw,Vishnu Muraleedharan Saraswathy,Anthony R McAdow et al.
Dana Klatt Shaw et al.
Immune cells elicit a continuum of transcriptional states after spinal cord injury (SCI). In mammals, inefficient debris clearance and chronic inflammation impede recovery and overshadow pro-regenerative immune functions. We found that zebr...
Unconventional activation of the proto-oncogene FGFR1 by extracellular phosphate via H2O2-mediated kinase oxidation [0.03%]
过氧化氢介导的受体激酶氧化激活原癌基因FGFR1的新机制
Michal Kostas,Else Munthe,Ellen Margrethe Haugsten et al.
Michal Kostas et al.
Fibroblast Growth Factor Receptors (FGFRs) are important cellular signaling mediators and are implicated in numerous cancers, including osteosarcoma (OS). Recent research shows that FGFR1 participates in inorganic phosphate (Pi) sensing in ...