Disrupted mitochondrial dynamics activate RNA-sensing innate immunity through mitochondrial RNA release [0.03%]
线粒体动力学受损通过释放线粒体RNA激活RNA感应天然免疫反应
Tatsuki Yasuda,Aoi Ichikawa,Kenta Onoue et al.
Tatsuki Yasuda et al.
Mitochondria are dynamic organelles that continuously remodel their morphology through fusion and fission in response to cellular cues. While this dynamic behavior is essential for diverse cellular functions, how mitochondrial dynamics infl...
Chloroplast photorespiratory bypass in tomato couples carbon-nitrogen assimilation to increase yield and fruit quality [0.03%]
番茄叶绿体光呼吸旁路耦联碳氮同化以提高产量和果实品质
Qian Luo,Yuqing Ma,Hua Liu et al.
Qian Luo et al.
Photorespiration is vital for C3 plant carbon (C) and nitrogen (N) metabolism, yet most engineering ignores N-related constraints. Here, we engineered a chloroplast-targeted bypass in tomato (GCMG), comprising glycolate oxidase 1 (SlGLO1), ...
Parabrachial inputs to the parafascicular thalamus drive sensory and affective-motivational responses to cold-allodynia in mice [0.03%]
外侧导血管与鼠类冷过敏的丘脑片束核感觉及情感能量反应的输入驱动作用
Prannay Reddy,Mousmi Rani,Jagat Narayan Prajapati et al.
Prannay Reddy et al.
Tonic pain engages both sensory and affective-motivational processes, which are partially mediated by the medial thalamus. However, the circuit mechanisms by which distinct medial thalamic subnuclei contribute to pain-related behaviors rema...
The TNRC6B/circTNRC6B axis drives lymphovascular invasion and metastasis through an intragenic self-degradation loop [0.03%]
TNRC6B/circTNRC6B轴通过内含子级联自我降解驱动淋巴管侵犯及转移
Lingjiao Meng,Haotian Wu,Jiaxiang Wu et al.
Lingjiao Meng et al.
Lymphovascular invasion (LVI) is a critical early step in metastasis, yet the mechanisms remain elusive. We identify an intragenic antagonistic loop between TNRC6B and circTNRC6B that determines LVI and metastasis in esophageal squamous cel...
Pyruvate-formate lyase-derived formate regulates the response of Salmonella Typhimurium to meropenem and ciprofloxacin [0.03%]
丙酮酸-甲醛裂解酶衍生的甲酸调节鼠伤寒沙门氏菌对美罗培南和环丙沙星的反应
Debapriya Mukherjee,Sakshi Vasant Wagle,Pallab Ghosh et al.
Debapriya Mukherjee et al.
Salmonella enterica serovar Typhimurium (STM) employs various strategies to endure antibiotic stress, but the contribution of central metabolites to resistance remains insufficiently characterized. In this work, we identify intracellular fo...
The calcium pump ATP2B1/PMCA1 regulates CNS vascular development by facilitating Norrin- and WNT7A/B-induced Frizzled4 signaling [0.03%]
钙泵ATP2B1/PMCA1通过促进Norrin和WNT7A/B诱导的Frizzled4信号转导调节中枢神经系统血管发育
Ha-Neul Jo,Elizabeth Kiffmeyer,Chi Zhang et al.
Ha-Neul Jo et al.
Frizzled4 (FZD4) is a receptor for Norrin and WNT7A/B ligands, is expressed in endothelial cells (ECs), is required for endothelial blood-central nervous system (CNS) barrier function as well as CNS angiogenesis, and transduces β-catenin-d...
GRHL and PGR control WNT4 expression via 3D looping of conserved and species-specific enhancers [0.03%]
GRHL和PGR通过保守的和物种特异性的增强子的三维环化控制WNT4表达
Yorick B C van de Grift,Marleen T Aarts,Katrin E Wiese et al.
Yorick B C van de Grift et al.
Developmental gene expression is tightly regulated by tissue-specific enhancers. Understanding this process in the context of the three-dimensional (3D) genome requires dedicated interrogation on a per gene and per tissue basis. Here, we fu...
Histone lactylation-driven intratumoral IGFBP2+ NK cells promote tumor immune evasion [0.03%]
组蛋白乳酰化驱动的瘤内IGFBP2+NK细胞促进肿瘤免疫逃逸
Xuben Wang,Zhuanghao Hou,Qikai Sun et al.
Xuben Wang et al.
Natural killer (NK) cells are known for their cytotoxic and regulatory functions in immune responses. Here, we identify a subset of insulin-like growth factor binding protein 2 (IGFBP2)+ NK cells enriched in liver cancer, exhibiting impaire...
Red bone marrow hosts metabolically active anucleate adipocytes that support hematopoiesis [0.03%]
红骨髓中的代谢活跃的无核脂肪细胞可促进造血干细胞生成
Sauyeun Shin,Marine Hernandez,Stéphanie Dauvillier et al.
Sauyeun Shin et al.
Bone marrow adipocytes (BMAds) are a major component of the bone marrow (BM) that regulate bone turnover and hematopoiesis. In rodents, two distinct adipocyte populations exist: constitutive BMAds (cBMAds), located in areas devoid of hemato...
Paf1 Counteracts transcriptional arrest to maintain rDNA stability during pol I elongation [0.03%]
Paf1通过对抗转录阻滞来维持RNA聚合酶I延长过程中的rDNA稳定性
Zijun Zhong,Masaaki Yokoyama,Takehiko Kobayashi
Zijun Zhong
Genomic instability drivers of senescence and carcinogenesis. The ribosomal RNA gene (rDNA) locus in budding yeast provides an excellent model to study these processes. Because of its highly repetitive structure and the gene amplification s...