Distinct compositional changes but shared quantitative microbiome and anti-inflammatory modulations by diet [0.03%]
饮食引起的肠道微生物组定性和定量变化及其抗炎调节作用
Hannah K Ruple,Lynn Schintgen,Eva Haasis et al.
Hannah K Ruple et al.
Gut microbiome composition has been frequently but inconsistently associated with human disease. Using a food dye-based gastrointestinal (GI) passage assay to measure GI transit time, stool production (fecal mass), fecal microbiota density ...
HPD is a copper-binding protein that interacts with DLAT to promote colorectal cancer cuproptosis under copper stress [0.03%]
HPD是一种铜结合蛋白，通过与DLAT互作促进结直肠癌细胞铜应激下的铜依赖性细胞死亡（cuproptosis）
Xintong Dai,Lumeng Liu,Mengxin Tu et al.
Xintong Dai et al.
Copper is an essential trace element involved in various physiological processes. However, excessive copper levels in cells trigger cellular toxicity and "cuproptosis". Nevertheless, its role and the underlying mechanisms of cuproptosis in ...
Rotational trophoblast organoids reveal biomechanical regulation of trophoblast differentiation [0.03%]
旋转滋养层器官模型揭示了机械力对滋养细胞分化的调控作用
Shun Shibata,Yuki Ishikawa,Marina Kosaka et al.
Shun Shibata et al.
Human placental development is essential for pregnancy but remains mechanistically obscure because early post-implantation tissues are inaccessible. Here, we establish a rotational trophoblast organoid platform that recapitulates selected m...
Dysregulated calcium signaling underlies hyposalivation and microbial dysbiosis in Down syndrome [0.03%]
唐氏综合症低唾液分泌和微生物群失调源于钙信号转导紊乱
Ga-Yeon Son,Guilherme H S Bomfim,Fangxi Xu et al.
Ga-Yeon Son et al.
Individuals with Down syndrome (DS) produce less saliva for unknown reasons resulting in chronic periodontal disease with systemic detrimental effects. Using the (Dp(16)1Yey) mouse model of DS we define the molecular mechanisms of hyposaliv...
Collagen 1-mediated CXCL1 secretion in tumor cells activates fibroblasts to promote radioresistance of esophageal cancer [0.03%]
肿瘤细胞分泌的I型胶原蛋白介导的CXCL1分泌激活成纤维细胞促进食管癌放疗抵抗
Xinyu Yang,Xinjie Chen,Shaosen Zhang et al.
Xinyu Yang et al.
Published Erratum
Cell reports. 2026 Jul 1;45(7):117673. DOI:10.1016/j.celrep.2026.117673 2026
Identification of superstalsis, a motility program distinct from peristalsis in the Drosophila midgut [0.03%]
识别超级蠕动：果蝇肠道中不同于常规蠕动的运动程序
Niccolò P Pampaloni,Isabella S Balles,Paula Düllmann et al.
Niccolò P Pampaloni et al.
Enteric organs display the intrinsic ability to generate slow-wave potentials, rhythmic electrochemical events regulating gastrointestinal motility. In mammals, slow waves arise from the pacemaker activity of interstitial cells of Cajal, wh...
HDAC10 promotes Th17 differentiation and IL-17A-driven neutrophilic airway inflammation in severe asthma [0.03%]
组蛋白脱乙酰酶10促进重度哮喘中T辅助细胞17分化及白介素17A驱动的气道中性粒细胞炎症
Yu Zhong,Tong Huang,Zhihang Feng et al.
Yu Zhong et al.
Severe asthma frequently manifests as a neutrophilic phenotype associated with dysregulated Th17 cell response, yet the molecular mechanism regulating Th17 cell-driven pathology remain poorly defined. Here, we identified histone deacetylase...
Outer membrane remodeling via lipid-peptidoglycan crosstalk enables lipooligosaccharide-deficient colistin resistance [0.03%]
通过脂质-肽聚糖交叉对话介导的外膜重塑使脂寡糖缺乏型多粘菌素耐药成为可能
Roberto Jhonatan Olea-Ozuna,Berenice Furlan,Hanling Gong et al.
Roberto Jhonatan Olea-Ozuna et al.
Gram-negative bacteria rely on an asymmetric outer membrane for barrier integrity, with phospholipids confined to the inner leaflet and lipopolysaccharide or lipooligosaccharide (LOS) forming the outer leaflet. Although these glycolipids we...
The gut microbiome of a Northern Plains tribe is in transition between global Indigenous and industrialized populations [0.03%]
北平原土著部落的肠道微生物群介于全球土著人群和工业化人群之间
Audra L Crouch,Molly Rambeau,Jennifer Li-Pook-Than et al.
Audra L Crouch et al.
The human gut is shaped by environmental factors, producing distinct microbial communities. Indigenous individuals practicing traditional lifestyles often harbor more diverse microbiota, with taxa often absent in industrialized people. Howe...
The pyroptosis cascade between inflammatory endothelial cells and microglia facilitates BBB disruption in bacterial meningitis [0.03%]
炎症内皮细胞和小胶质细胞之间的焦亡级联反应可促进细菌性脑膜炎引起的血脑屏障破坏
Yangyang Zheng,Zhiyue Wu,Fei Wu et al.
Yangyang Zheng et al.
Neonatal meningitis-causing Escherichia coli (NMEC) is a primary etiological agent of neonatal meningitis. Inflammatory cell death triggered by NMEC infection has been implicated as a critical determinant of blood-brain barrier (BBB) disrup...