A non-catalytic function for RAD18 in sustaining glioblastoma proliferation [0.03%]
RAD18的一个非催化功能可维持胶质母细胞瘤增殖
Nour Benbahouche,Antoine Aze,Aurore Siegfried et al.
Nour Benbahouche et al.
The RAD18 (E3) ubiquitin ligase, a key DNA damage tolerance regulator that also functions in DNA double-strand break repair, is overexpressed in the brain cancer glioblastoma. Here, we show that RAD18 promotes glioblastoma cell proliferatio...
Lu Qian,Ruilin Su,Wenbo Wang et al.
Lu Qian et al.
Coastal ecosystems play critical roles in biogeochemical cycling, food webs, climate regulation, and aquaculture. Their functions are shaped by multitrophic interactions across microbe-microbe, microbe-plant, and microbe-animal interfaces, ...
Genome-wide atlas of lncRNAs in Mucorales reveals conserved regulators essential for fungal viability and development [0.03%]
曲霉属真菌长链非编码RNA的全基因组图谱揭示了保守的转录调节因子对真菌存活和发育至关重要
Ghizlane Tahiri,Hrant Hovhannisyan,Carlos Lax et al.
Ghizlane Tahiri et al.
Long non-coding RNAs (lncRNAs) are key regulators across eukaryotes, yet their functions in non-Dikarya fungal pathogens remain largely unexplored. Here, we provide a comprehensive identification and characterization of lncRNAs in the non-D...
Complex I drives glutamine-dependent TCA cycle to support viability of MYChigh breast cancer cells [0.03%]
复杂I驱动谷氨酰胺依赖性TCA循环以维持MYC高度乳腺癌细胞的生存能力
Johanna M Anttila,Mariel Savelius,Linda Id et al.
Johanna M Anttila et al.
In many cancers, stably elevated MYC levels drive sustained activation of anabolic programs and the cell cycle, creating opportunities for the synthetic-lethal targeting of MYChigh tumors. Enhanced mitochondrial respiration is a hallmark of...
STING-dependent peripheral inflammaging drives neurodegeneration via extracellular vesicles [0.03%]
依赖于STING的外周组织衰老通过细胞外囊泡驱动神经退行性病变
Maria Öberg,Caitlyn Myers,Najmeh Saffarzadeh et al.
Maria Öberg et al.
All animals age. However, aging is a heterogeneous process, and individual organisms age differently. Moreover, within the same organism, cells or organs do not age at the same speed. For instance, neurodegeneration, a hallmark of aging, ge...
Glioblastoma stem cell growth requires DOT1L-MED23 control of enhancer accessibility [0.03%]
DOT1L-MED23调控增强子可及性控制胶质母细胞瘤干细胞增殖
Samir Assaf,Danielle A Bozek,Kyle Heemskerk et al.
Samir Assaf et al.
Harboring a low mutational burden, glioblastoma relies on various epigenetic regulators to fuel its development and progression, several of which remain mechanistically enigmatic. Here, we show that the histone methyltransferase DOT1L shape...
H4K16ac contributes to chromatin compartment reorganization during mitotic and meiotic transitions [0.03%]
H4K16乙酰化有助于有丝分裂和减数分裂过程中的染色质区室重组
Yuling Zhao,Bhabesh Kumar Tripathy,Maria Shvedunova et al.
Yuling Zhao et al.
Chromatin compartments reorganize dramatically during cell-cycle transitions, shifting from a compartmentalized interphase to a condensed mitotic configuration in which large-scale compartment signals are attenuated. While histone modificat...
Comparative population genomics reveals adaptive convergence in two Drosophila species across global environments [0.03%]
比较群体基因组学揭示了两种果蝇在环球环境下的适应性趋同现象
Weixuan Li,Junhao Chen,Chenlu Liu et al.
Weixuan Li et al.
The predictability of evolution across lineages remains unclear. We examine repeated adaptation in the globally distributed sibling species, Drosophila melanogaster and D. simulans. We assemble a high-quality reference genome for D. simulan...
Dissociation of CCDC25 dimer into NETs-DNA-bound monomer licenses inflammatory activation of fibroblast-like synoviocytes in rheumatoid arthritis [0.03%]
CCDC25二聚体解离为单体并结合NETs-DNA，从而在类风湿关节炎中激活滑膜成纤维细胞导致炎症反应
Yuchen Zhao,Han Wang,Menglin Bai et al.
Yuchen Zhao et al.
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovium infiltration of immune cells, leading to inflammatory activation of fibroblast-like synoviocyte (FLS). Neutrophils infiltrate the synovium early in RA and e...
Defining and characterizing the relevant state variables of the mammalian gut ecosystem [0.03%]
界定和表征哺乳动物肠道生态系统中的相关状态变量
Joe Lim,Sean M Gibbons
Joe Lim
Ruple et al.1 explores the potential of a set of quantitative gut microbiome parameters as diagnostic and therapeutic readouts beyond gut microbiome taxonomic composition or gene content. The authors profile QMPs' changes across diets and m...