DHODH is a synthetic lethal target in PIK3CA-mutant colorectal cancer [0.03%]
DHODH是PIK3CA突变结直肠癌的合成致死靶点
Jun Liang,Xi Liu,Ziyun Ni et al.
Jun Liang et al.
Cancer cells acquire distinct metabolic and signaling dependencies driven by oncogenic mutations. Defining these mutation-specific liabilities can uncover therapeutic opportunities. Here, we identify dihydroorotate dehydrogenase (DHODH) as ...
Distinct systemic and gut IgA responses to bacteria of the human upper gastrointestinal tract [0.03%]
人类上消化道细菌的系统性和肠道IgA反应特征不同
Filipa Vaz,Ida Lindeman,Henriette H Hoffmann et al.
Filipa Vaz et al.
The mucosa lining the gastrointestinal tract harbors the body's largest population of plasma cells, most of which produce dimeric immunoglobulin A (IgA) for release into the lumen. In addition, there is systemic production of monomeric IgA ...
3D nanoscale reconstruction of human airway multiciliogenesis reveals cellular architecture remodeling and cilia-mitochondria link via rootlets [0.03%]
人呼吸道纤毛发生的三维纳米重建揭示了细胞骨架重塑和基体-线粒体连接关系
Aaran Vijayakumaran,Christopher Godbehere,Analle Abuammar et al.
Aaran Vijayakumaran et al.
A central challenge in single-cell biology is understanding how molecular programs drive changes in cellular architecture that enable specialized function. A striking example of cellular remodeling is the differentiation of airway stem cell...
Proinflammatory signaling in Ewing sarcoma is driven by retroelement activity and counteracted by reverse transcriptase inhibitors [0.03%]
逆转录酶抑制剂拮抗长散在元件引起的EWING肉瘤促炎症信号通路
Valentina Evdokimova,Peter Ruzanov,Hendrik Gassmann et al.
Valentina Evdokimova et al.
Ewing sarcoma (EwS) is a childhood malignancy driven by oncogenic fusion proteins, most commonly EWS::FLI1, and is characterized by paradoxical co-occurrence of inflammation and immunosuppression. Our study shows that LINE, SINE, and LTR/HE...
Bcl11a orchestrates multilineage integrity in aging hematopoiesis by regulating multipotent progenitor fate decisions [0.03%]
Bcl11a通过调节多能祖细胞的命运决定来协调衰老造血过程中的多谱系完整性
Linlin Zhang,Xiang Xu,Jing Wang et al.
Linlin Zhang et al.
Aging hematopoiesis exhibits progressive myeloid skewing and impaired lymphopoiesis, driving age-related blood disorders. We show that multipotent progenitors (MPPs) mediate this lineage imbalance. Aging expands myeloid-biased MPP3 cells wh...
Jielong Guo,Changtao Jiang
Jielong Guo
Early life is a critical window for the establishment of immune tolerance, but the factors that govern this process remain incompletely understood. In a study published in Cell Metabolism, Zheng et al.1 found that neonates selectively enric...
A genome-wide functional analysis of conserved intronic regions reveals essential roles for speckle-associated retained introns [0.03%]
染色质开放区域及功能性保留内含子的全基因组分析揭示了斑点相关保留内含子的重要作用
Shaghayegh Farhangmehr,Ulrich Braunschweig,Mingkun Wu et al.
Shaghayegh Farhangmehr et al.
Hundreds of human introns harbor extended regions of high evolutionary conservation that have not been previously characterized. A survey of these sequences reveals that they are associated with intron retention and enriched in genes that f...
AXL phosphosite mapping links FAK1 and YAP1 signaling to erlotinib resistance in EGFR-mutant lung cancer [0.03%]
AXL磷酸化位点鉴定建立了FAK1和YAP1信号与表皮生长因子受体突变型肺癌中厄洛替尼耐药之间的联系
Marc Creixell,Scott D Taylor,Jacqueline Gerritsen et al.
Marc Creixell et al.
Targeted therapies for receptor tyrosine kinases are effective but invariably limited by drug resistance. In EGFR-mutant lung cancer, AXL activation drives resistance to erlotinib by restoring cell survival and migration. To map these signa...
A cortical-subcortical circuit underlies pain sensitization driven by sleep deprivation [0.03%]
睡眠不足引起的痛觉敏感的皮层-亚皮层环路机制研究
Ruizhen Huang,Yuting Wang,Boyu Jiao et al.
Ruizhen Huang et al.
Sleep disorders cause pain, yet the underlying neural circuits remain largely unknown. Using brain-wide neural tracing, optogenetics, chemogenetics, in vivo fiber photometry, and electrophysiological recording, we identified a retrosplenial...
SUDS3 nuclear condensates decelerate DNA replication and safeguard genome stability [0.03%]
SUDS3核凝聚物可减慢DNA复制并保护基因组稳定性
Zhifen Zhou,Kunling Huang,Ruofei Li et al.
Zhifen Zhou et al.
Faithful DNA replication requires precise control of replication fork progression to maintain genome integrity; yet, the mechanisms that restrain excessive fork acceleration remain unclear. We identify SUDS3 as a condensate-associated regul...