Proinflammatory signaling in Ewing sarcoma is driven by retroelement activity and counteracted by reverse transcriptase inhibitors
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Ewing sarcoma (EwS) is a childhood malignancy driven by oncogenic fusion proteins, most commonly EWS::FLI1, and is characterized by paradoxical co-occurrence of inflammation and immunosuppression. Our study shows that LINE, SINE, and LTR/HERV endogenous retrov... ...
