Multiscale symbolic morpho-barcoding reveals region-specific and scale-dependent neuronal organization [0.03%]
多尺度符号形态条形码揭示了区域特异性和尺度依赖性的神经组织模式
Sujun Zhao,Yingxin Li,Hanchuan Peng et al.
Sujun Zhao et al.
Neuronal morphology shapes circuit organization, yet its multiscale complexity has hindered systematic brain-wide analysis. Here, we introduce multiscale morpho-barcoding (MMB), a framework that encodes whole-brain neuronal morphology into ...
Tracing NAD+ metabolism uncovers adaptive coordination between host and microbiome during colitis [0.03%]
追踪NAD+代谢揭示了结肠炎期间宿主与微生物组之间的自适应协调作用
Abrar I Alsaadi,Lina Wehkamp,Anant A Pothakamury et al.
Abrar I Alsaadi et al.
Host-microbiota metabolic interactions critically regulate nicotinamide adenine dinucleotide (NAD+) homeostasis, and their disruption is increasingly linked to chronic diseases, including inflammatory bowel disease (IBD). However, it remain...
Sex differences in somatosensory circuitry are programmed by developmental microglia-astrocyte interaction [0.03%]
发育过程中微胶质细胞-星形胶质细胞相互作用编程感觉通路性别差异
Abigayle Duffy,Leigh Ellen Fremuth,Madison Doceti et al.
Abigayle Duffy et al.
Men possess a greater density of cortical synapses in the adult brain relative to women, but the underlying mechanism and functional significance of this sex difference is unclear. Here, we identify a greater density of excitatory synapses ...
Avi Matarasso,Itzel Rodriguez Reyes,Elena Seaholm et al.
Avi Matarasso et al.
Arousal is essential for survival, and maladaptive arousal processing leads to an inability to focus, anxiety-like behavior, and dysregulated affective states. Norepinephrine (NE) is known to regulate anxiety, arousal, and learning through ...
Human GBP4 promotes TRIM21-BIP-dependent autophagy to restrict M. tuberculosis infection by preventing SORT1-mediated progranulin degradation [0.03%]
人源GBP4通过阻止SORT1介导的前列腺素降解来促进TRIM21-BIP依赖性自噬限制结核分枝杆菌感染
Qinglong Guo,Jing Bi,Yu Fu et al.
Qinglong Guo et al.
Interferons (IFNs) are potent antimicrobial cytokines. However, effector mechanisms mediating their function in humans are poorly understood, partly because IFNs can induce numerous effector molecules. While guanylate-binding proteins (GBPs...
Anna M Newen,Uzair A Ansari,Mikala J Simpson et al.
Anna M Newen et al.
Self-reactive B cells arise during development and can increase pathogenicity through activation-induced cytidine deaminase (AID)-mediated diversification. Clonal deletion is thought to eliminate these cells, yet how deletion is distributed...
Marta Parrilla,Robert Hülse,Jing Jin et al.
Marta Parrilla et al.
Neural circuit assembly requires precise coordinated interactions between developing neurons and the vasculature; yet, the instructive signals provided by endothelial cells remain largely unknown. Here, we find a vascular-to-neural signalin...
Bidirectional control of vesicular GABA release, LTP, and amotivation by GluN2D-selective allosteric modulators and ketamine [0.03%]
选择性正向别构调节剂和氯胺酮通过GluN2D双向调控囊泡GABA释放、长时程增强和动机行为控制
Viktor J Oláh,Isabelle F Witteveen,Tue G Banke et al.
Viktor J Oláh et al.
GABAergic inhibitory interneurons balance brain activity by suppressing excessive excitatory signaling and shaping network oscillations. Despite this critical function, our understanding of how neural circuits regulate GABAergic systems rem...
Kazuki Okamoto,Yasuhiro R Tanaka,Shigeki Kato et al.
Kazuki Okamoto et al.
Motor preferences, such as handedness, reflect asymmetries in brain function across vertebrates. Although generally stable, these hand or paw preferences can be reshaped through experience or training; however, the neural basis of such swit...
Lactation increases food seeking and palatable feeding through mesolimbic dopamine signaling in mice [0.03%]
催乳素通过多巴胺能信号通路增加小鼠觅食及寻食行为
Tanya Pattnaik,Vraj Patel,Jared Butts et al.
Tanya Pattnaik et al.
Lactation dramatically increases energy intake to support milk production and the care for the offspring. However, the behavioral and neural circuit mechanisms driving heightened feeding during lactation remain unclear. Here, we reveal that...