Evaluation of the Migrastatic Properties of Selective MMP-2 Inhibitors in Colorectal Cancer: An In Ovo Approach [0.03%]
结直肠癌选择性MMP-2抑制剂迁移静力特性的评估：一种ovo方法
Nikunj Parekh,Mansi Patel,Praysha Patel et al.
Nikunj Parekh et al.
Colorectal cancer accounts for about 10% of all cancer diagnoses and is the second leading cause of cancer-related death. Until the cancer has progressed to an advanced stage, colorectal cancer typically shows no symptoms. The medications c...
Protective Effect of Boldine Against Diclofenac-Induced Renal Damage in Rats [0.03%]
小檗碱对diclofenac所致大鼠肾损伤的保护作用研究
Luísa Nathália Bolda Mariano,Heloísa Roberti Cristofolini,Rita de Cássia Vilhena da Silva et al.
Luísa Nathália Bolda Mariano et al.
This study investigated the protective effect of alkaloid boldine against diclofenac-induced kidney damage in normotensive female rats. Animals were divided into three groups: naive, vehicle+diclofenac (50 mg/kg), and boldine+diclofenac (bo...
Gallic Acid Induces Apoptosis in Oral Squamous Cell Carcinoma via PI3K/AKT/mTOR Pathway Inhibition and PTEN Upregulation: an In Vitro Study [0.03%]
原花青酸通过抑制PI3K / AKT / mTOR途径和上调PTEN在体外诱导口腔鳞状细胞癌凋亡
Sanaz Helli,Armin Heidari,Armin Tafvizi et al.
Sanaz Helli et al.
Oral squamous cell carcinoma is one of the most common head and neck cancers, which is associated with drug resistance and high mortality rates. The PI3K/AKT/mTOR pathway plays a crucial role in the survival, growth, and metastasis of cance...
Investigating the Protective Role of Vitamin D Supplementation on Cyclophosphamide-Induced Liver Enzyme Alterations in Adult Male Rats [0.03%]
调查维生素D补充剂对环磷酰胺诱导的成年雄性大鼠肝酶改变的保护作用
Tania Nazem,Ali Hosseini-Sharifabad,Mohammad Reza Mofid et al.
Tania Nazem et al.
Cyclophosphamide is known to cause liver dysfunction. This study investigated the protective role of vitamin D supplementation against cyclophosphamide -induced liver dysfunction in adult male rats. The rats receiving cyclophosphamide were ...
Diosgenin Enhances the Sensitivity to Methotrexate Through Oxidative DNA Damage in Saos-2 Osteosarcoma Cancer Cells [0.03%]
薯蓣皂苷通过氧化性DNA损伤增强骨肉瘤细胞株Saos-2对甲氨蝶呤的敏感性
Hadi Ghobadi,Amir Valizadeh,Mohsen Dashti et al.
Hadi Ghobadi et al.
Previously, diosgenin, a steroidal saponin, has demonstrated therapeutic potential for osteosarcoma. However, the underlying mechanisms still remain unknown.This study was designed to investigate the impact of diosgenin on methotrexate-medi...
Resveratrol Sensitizes Temozolomide-Resistant Glioblastoma Cells Through Mitogen-Activated Protein Kinase Pathway Inhibition and P-Glycoprotein Modulation [0.03%]
白藜芦醇通过抑制丝裂原活化蛋白激酶途径和调节P-糖蛋白使替莫唑胺耐药的胶质母细胞瘤细胞重新敏感化
Maede Rezaie,Mohammad Nasehi,Dariush Shanehbandi et al.
Maede Rezaie et al.
Glioblastoma multiforme continues to pose a major therapeutic challenge due to its high level of treatment resistance and poor prognosis. Temozolomide is a standard chemotherapeutic agent, but resistance significantly limits its clinical ef...
Evaluation of a Retinol Nanoemulsion Gel Enriched with Black Seed and Rosehip Oils for Acne Management [0.03%]
富含黑种草籽油和玫瑰果油的视黄醇纳米乳凝胶剂治疗痤疮的评估研究
Aishwarya Reddy,Ashwin Ravichandran,Sai Varshini Magham
Aishwarya Reddy
Acne vulgaris, a prevalent inflammatory skin condition, impacts both appearance and quality of life, especially in adolescents. This study explores a novel treatment combining black seed oil, rosehip oil, and retinol within a nanoemulsion t...
Lasmiditan in Migraine Management: An Advanced Review of Its Pharmacological Paradigm, Clinical Applications, Safety Considerations, Drug Interaction Spectrum, and Regulatory Approval [0.03%]
偏头痛管理中的Lasmiditan：其药理学范式、临床应用、安全性考虑、药物相互作用谱及监管审批的高级综述
Krutuja R Chougule,Archana S Patil,Swapnil Patil
Krutuja R Chougule
This review offers an in-depth evaluation of Lasmiditan, a novel and selective 5-HT1F receptor agonist, representing a significant breakthrough in migraine pharmacotherapy. Unlike existing reviews, this article consolidates all critical asp...
Characterization and Therapeutic Assessment of Phytomediated Silver Nanoparticles Produced from the Stem Bark of Bombax ceiba [0.03%]
来源于Bombax ceiba树干皮的植物介导法制备银纳米颗粒的表征及治疗评估
Narendhar Dharavath,Mahendar Porika,Radhika Tippani et al.
Narendhar Dharavath et al.
The study aims to develop an environmentally friendly method of producing silver nanoparticles using an extract from Bombax ceiba stem bark (Bc-AgNPs) and to investigate their potential medical applications, such as preventing blood cell da...
Repurposing FDA-Approved Drugs as Fructosamine-3-Kinase Inhibitors: A Mechanistic and Translational Approach to Redox-Driven Cancer Therapy [0.03%]
一种机制和转化方法：将FDA已批准的药物重新用于醛糖还原酶抑制剂，以驱动癌症治疗
Erica Alves,Gurupadayya Bannimath,Prabitha Prabhakaran
Erica Alves
Fructosamine-3-kinase (FN3K), a deglycating enzyme originally studied in the context of diabetes, has recently emerged as a pivotal modulator of redox homeostasis and therapeutic resistance in cancer. FN3K catalyzes the removal of early gly...