Evaluation of a Retinol Nanoemulsion Gel Enriched with Black Seed and Rosehip Oils for Acne Management [0.03%]
富含黑种草籽油和玫瑰果油的视黄醇纳米乳凝胶剂治疗痤疮的评估研究
Aishwarya Reddy,Ashwin Ravichandran,Sai Varshini Magham
Aishwarya Reddy
Acne vulgaris, a prevalent inflammatory skin condition, impacts both appearance and quality of life, especially in adolescents. This study explores a novel treatment combining black seed oil, rosehip oil, and retinol within a nanoemulsion t...
Lasmiditan in Migraine Management: An Advanced Review of Its Pharmacological Paradigm, Clinical Applications, Safety Considerations, Drug Interaction Spectrum, and Regulatory Approval [0.03%]
偏头痛管理中的Lasmiditan：其药理学范式、临床应用、安全性考虑、药物相互作用谱及监管审批的高级综述
Krutuja R Chougule,Archana S Patil,Swapnil Patil
Krutuja R Chougule
This review offers an in-depth evaluation of Lasmiditan, a novel and selective 5-HT1F receptor agonist, representing a significant breakthrough in migraine pharmacotherapy. Unlike existing reviews, this article consolidates all critical asp...
Characterization and Therapeutic Assessment of Phytomediated Silver Nanoparticles Produced from the Stem Bark of Bombax ceiba [0.03%]
来源于Bombax ceiba树干皮的植物介导法制备银纳米颗粒的表征及治疗评估
Narendhar Dharavath,Mahendar Porika,Radhika Tippani et al.
Narendhar Dharavath et al.
The study aims to develop an environmentally friendly method of producing silver nanoparticles using an extract from Bombax ceiba stem bark (Bc-AgNPs) and to investigate their potential medical applications, such as preventing blood cell da...
Repurposing FDA-Approved Drugs as Fructosamine-3-Kinase Inhibitors: A Mechanistic and Translational Approach to Redox-Driven Cancer Therapy [0.03%]
一种机制和转化方法：将FDA已批准的药物重新用于醛糖还原酶抑制剂，以驱动癌症治疗
Erica Alves,Gurupadayya Bannimath,Prabitha Prabhakaran
Erica Alves
Fructosamine-3-kinase (FN3K), a deglycating enzyme originally studied in the context of diabetes, has recently emerged as a pivotal modulator of redox homeostasis and therapeutic resistance in cancer. FN3K catalyzes the removal of early gly...
Sinapic Acid Protects Mortality and Toxicity Induced by N-Ethyl-N-Nitrosourea, a Full Carcinogen Agent, in Mice [0.03%]
芥子酸对硝基乙胺所致小鼠死亡和毒性的保护作用
Ahmad Salimi,Mahshad Pourgholi,Saleh Khezri et al.
Ahmad Salimi et al.
We investigated, in vivo, the chemopreventive efficacy of sinapic acid, as a known radical scavenger and antioxidant on mortality and toxicity in a N-ethyl-N-nitrosourea (ENU)-induced chronic lymphocytic leukemia (CLL) model in mice.Mice we...
Transforming Drug Therapy with Deep Learning: The Future of Personalized Medicine [0.03%]
用深度学习转化药物治疗：个性化医疗的未来
Altaf Osman Mulani,Minal Deshmukh,Vaishali Jadhav et al.
Altaf Osman Mulani et al.
Personalized medicine represents a paradigm shift in healthcare, aiming to tailor treatment strategies to the unique genetic, environmental, and lifestyle characteristics of individual patients. This approach holds immense potential for imp...
Maternal Mirtazapine Selectively Enhances Hippocampal LTP without Reversing Stress-Associated Alterations in Basal Transmission, Short-Term Plasticity, or Open Field Behaviour in Rat Offspring [0.03%]
母亲米塔扎平选择性地增强了大鼠后代海马长时程增强，而不会逆转压力相关的基础传导、短期可塑性或开放式行为的改变
Zdenka Gasparova,Stanislava Bukatova,Michal Dubovicky
Zdenka Gasparova
Maternal stress during pregnancy has profound effects on offspring, disrupting brain development and behaviour. Mirtazapine, an antidepressant commonly prescribed for maternal depression, has an unclear impact on offspring neurophysiology a...
Pembrolizumab-associated hepatobiliary disorders: a real-world pharmacovigilance study using the FDA Adverse Events Reporting System (FAERS) [0.03%]
基于FDA不良事件报告系统的真实世界药物警戒研究：帕博利珠单抗相关肝胆疾病
Likun Ding,Ning Ma,Meiyou Liu et al.
Likun Ding et al.
The aim of this study was to evaluate hepatobiliary disorders adverse events associated with pembrolizumab by using the Food and Drug Administration Adverse Event Reporting System (FAERS).We collected FAERS data from the first quarter of 20...
Synergistic Induction of Apoptosis and Cell Cycle Arrest against Breast Cancer Cells by Combined Kaempferol and Paclitaxel [0.03%]
kaempferol联合紫杉醇诱导乳腺癌细胞周期阻滞及凋亡的协同作用
Toofan Aghazadeh,Fatemeh Ramezani,Nuredin Bakhtiari et al.
Toofan Aghazadeh et al.
The study investigates the potential of combining Kaempferol (KAE) and Paclitaxel (PAC) to enhance anti-cancer effects and induce apoptosis in MDA-MB-468 triple-negative breast cancer cells and human normal foreskin fibroblast cells.For thi...
Infecting Cancer to Cure It: The Power of Oncolytic Viruses in Gynecologic Oncology - A Narrative Review [0.03%]
利用溶瘤病毒治疗妇科肿瘤——叙事综述
Naina Kumar
Naina Kumar
Gynecological cancers, including ovarian, cervical, and endometrial malignancies, contribute significantly to the global cancer burden. Oncolytic virotherapy (OVT), using both double-stranded DNA viruses (such as adenovirus, vaccinia, and h...