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Diosgenin Enhances the Sensitivity to Methotrexate Through Oxidative DNA Damage in Saos-2 Osteosarcoma Cancer Cells

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Previously, diosgenin, a steroidal saponin, has demonstrated therapeutic potential for osteosarcoma. However, the underlying mechanisms still remain unknown.This study was designed to investigate the impact of diosgenin on methotrexate-mediated apoptosis in Sa... ...