Ellagic Acid Attenuates Doxorubicin-induced Cardiomyocyte Ferroptosis Via Nuclear Factor Erythroid 2-Related Factor 2 Signaling [0.03%]
Rong Li,Zhong Cheng,Wei Li
Rong Li
Doxorubicin, a widely used chemotherapeutic agent, is clinically limited by its dose-dependent cardiotoxicity, in which cardiomyocyte ferroptosis has recently been identified as a critical pathogenic mechanism. Consequently, targeting myoca...
Effects of Sex and Fed State Differences on the Pharmacokinetics of Drugs in Humans [0.03%]
性别和禁食状态对人类药物动力学影响的研究进展
Omaimah Najib,Naji Najib,Nasir Mohammed Idkaidek
Omaimah Najib
Background: Sex and fed state are critical factors influencing drug pharmacokinetics, potentially affecting efficacy and safety. This study evaluates the impact of sex and food intake on key pharmacokinetics parameters-ma...
Protocatechuic Acid Ethyl Ester Protects Against Doxorubicin-induced Cardiotoxicity in Rats [0.03%]
乙基棓酸酯对多柔比星致大鼠心肌损伤的保护作用研究
Leila Safaeian,Maryam Farsiabi,Zahra Haghighatian et al.
Leila Safaeian et al.
Background: Doxorubicin, an anti-neoplastic agent, is linked with a risk of cardiotoxicity following acute or cumulative doses. Protocatechuic acid ethyl ester, as a natural phenolic acid derivative, inhibits a prolyl hyd...
Synergistic Effects of Curcumin and Temozolomide in Overcoming Glioblastoma Drug Resistance through Regulation of O6-Methylguanine-DNA Methyltransferase, Mismatch Repair, and Poly(Adenosine Diphosphate Ribose) Polymerase 1 [0.03%]
姜黄素和替莫唑胺通过调节O6-甲基鸟嘌呤-DNA甲基转移酶、错配修复和多（腺苷二磷酸）核糖聚合酶1来克服胶质母细胞瘤的药物抗性方面的协同作用
Masoud Sohrabi,Amir Valizadeh,Mehran Molavand et al.
Masoud Sohrabi et al.
Glioblastoma is one of the most frequently seen cancer types in the central nervous system, which is associated with drug resistance and high mortality rates. Curcumin demonstrates significant anticancer potential by inhibiting crucial proc...
Takezo Tsutsumi,Hitoshi Kashiwagi,Shungo Imai et al.
Takezo Tsutsumi et al.
Nausea and vomiting are commonly reported side effects of long-term linezolid therapy, which is indispensable for tuberculosis and osteoarticular infections. Since the mechanism underlying the development of nausea and vomiting during linez...
Counteractive Effects of Diarylpropionitrile on Testosterone-Induced Benign Prostatic Hyperplasia in Rats via Targeting Key Androgenic, Angiogenic, Proliferative, and Inflammatory Mechanisms [0.03%]
茋胺腈通过靶向关键雄激素、血管生成、增殖和炎症机制对睾丸素诱导的良性前列腺增生发挥对抗作用
Ahmed Khalafa Ali,Ahmed Rahmah Abu-Raghif,Hayder Ridha-Salman
Ahmed Khalafa Ali
Benign prostatic hyperplasia is a common public health problem in aging men across the globe. Diarylpropionitrile, a selective estrogen receptor-beta agonist, favorably regulates cell proliferation and inflammation, two major hallmarks of b...
Translational Insights into Liposomal Drug Delivery: Recent Advances, Therapeutic Applications, and Clinical Trials [0.03%]
脂质体药物递送的转化见解：近期进展、治疗应用和临床试验
Abdul Shadab,Abdul Faiz Ansari
Abdul Shadab
Liposomes are artificially constructed, phospholipid-based vesicular systems that have emerged as vital components in pharmaceutical nanotechnology and advanced drug delivery. Their flexible bilayered structure enables the encapsulation of ...
Correction: Treatment of K562 Cells with ABL Kinase Inhibitors Reveals Differential Metabolic Profiles [0.03%]
correction：ABL 激酶抑制剂处理K562细胞展现出不同的代谢谱型
Pranay Renukuntla,Sai Charitha Mullaguri,Divya Presingu et al.
Pranay Renukuntla et al.
Published Erratum
Drug research. 2026 Jan;76(1):e1. DOI:10.1055/a-2798-3571 2026
Wanlin Wang,Yue Liao,Ruizhi Zhang et al.
Wanlin Wang et al.
Vitiligo is a cutaneous autoimmune disease characterized by the destruction of epidermal melanocytes leading to white patches with a global prevalence of about 0.5-2%, and patients' quality of life are greatly affected by the change in appe...
Adverse Event Profile Differences Between Eliglustat and Miglustat: A Pharmacovigilance Study using the U.S. Food and Drug Administration Adverse Event Reporting System [0.03%]
艾拉格鲁司特与米格鲁司特不良事件差异的信号检测：基于美国食品药品监督管理局不良事件报告系统药物警戒研究
Ya Gan,Jie Liu,Chunyong Xia
Ya Gan
Both eliglustat and miglustat are substrate reduction therapies targeting glucosylceramide synthase; yet, their safety profile has not been comprehensively analyzed. This study analyzes adverse events associated with both drugs using the U....