Synergistic Effects of Curcumin and Temozolomide in Overcoming Glioblastoma Drug Resistance through Regulation of O6-Methylguanine-DNA Methyltransferase, Mismatch Repair, and Poly(Adenosine Diphosphate Ribose) Polymerase 1 [0.03%]
Masoud Sohrabi,Amir Valizadeh,Mehran Molavand et al.
Masoud Sohrabi et al.
Glioblastoma is one of the most frequently seen cancer types in the central nervous system, which is associated with drug resistance and high mortality rates. Curcumin demonstrates significant anticancer potential by inhibiting crucial proc...
Takezo Tsutsumi,Hitoshi Kashiwagi,Shungo Imai et al.
Takezo Tsutsumi et al.
Nausea and vomiting are commonly reported side effects of long-term linezolid therapy, which is indispensable for tuberculosis and osteoarticular infections. Since the mechanism underlying the development of nausea and vomiting during linez...
Counteractive Effects of Diarylpropionitrile on Testosterone-Induced Benign Prostatic Hyperplasia in Rats via Targeting Key Androgenic, Angiogenic, Proliferative, and Inflammatory Mechanisms [0.03%]
茋胺腈通过靶向关键雄激素、血管生成、增殖和炎症机制对睾丸素诱导的良性前列腺增生发挥对抗作用
Ahmed Khalafa Ali,Ahmed Rahmah Abu-Raghif,Hayder Ridha-Salman
Ahmed Khalafa Ali
Benign prostatic hyperplasia is a common public health problem in aging men across the globe. Diarylpropionitrile, a selective estrogen receptor-beta agonist, favorably regulates cell proliferation and inflammation, two major hallmarks of b...
Translational Insights into Liposomal Drug Delivery: Recent Advances, Therapeutic Applications, and Clinical Trials [0.03%]
脂质体药物递送的转化见解：近期进展、治疗应用和临床试验
Abdul Shadab,Abdul Faiz Ansari
Abdul Shadab
Liposomes are artificially constructed, phospholipid-based vesicular systems that have emerged as vital components in pharmaceutical nanotechnology and advanced drug delivery. Their flexible bilayered structure enables the encapsulation of ...
Correction: Treatment of K562 Cells with ABL Kinase Inhibitors Reveals Differential Metabolic Profiles [0.03%]
correction：ABL 激酶抑制剂处理K562细胞展现出不同的代谢谱型
Pranay Renukuntla,Sai Charitha Mullaguri,Divya Presingu et al.
Pranay Renukuntla et al.
Published Erratum
Drug research. 2026 Jan;76(1):e1. DOI:10.1055/a-2798-3571 2026
Wanlin Wang,Yue Liao,Ruizhi Zhang et al.
Wanlin Wang et al.
Vitiligo is a cutaneous autoimmune disease characterized by the destruction of epidermal melanocytes leading to white patches with a global prevalence of about 0.5-2%, and patients' quality of life are greatly affected by the change in appe...
Adverse Event Profile Differences Between Eliglustat and Miglustat: A Pharmacovigilance Study using the U.S. Food and Drug Administration Adverse Event Reporting System [0.03%]
艾拉格鲁司特与米格鲁司特不良事件差异的信号检测：基于美国食品药品监督管理局不良事件报告系统药物警戒研究
Ya Gan,Jie Liu,Chunyong Xia
Ya Gan
Both eliglustat and miglustat are substrate reduction therapies targeting glucosylceramide synthase; yet, their safety profile has not been comprehensively analyzed. This study analyzes adverse events associated with both drugs using the U....
Intramolecular Interactions of Twenty-Eight Amide Derivatives with the C-ALB Kinase using a Theoretical Model as a Therapeutic Alternative to Treat Cancer [0.03%]
基于理论模型的C-ALB蛋白激酶与二十八种酰胺衍生物的分子内相互作用研究及其抗癌应用前景
Marcela Rosas-Nexticapa,Magdalena Alvarez-Ramirez,Maria Virginia Mateu-Armad et al.
Marcela Rosas-Nexticapa et al.
Several studies have shown that some drugs can slow the growth of cancer cells by inhibiting the c-Abl kinase. However, some of these drugs can cause side effects such as gynecomastia, pulmonary toxicity, and lentiginosis, among others. In ...
Treatment of K562 Cells with ABL Kinase Inhibitors Reveals Differential Metabolic Profiles [0.03%]
ABL激酶抑制剂处理K562细胞揭示不同的代谢谱型
Pranay Renukuntla,Sai Charitha Mullaguri,Divya Presingu et al.
Pranay Renukuntla et al.
ABL kinase inhibitors have transformed the clinical management of chronic myelogenous leukemia; yet, the metabolic consequences of their use remain largely unexplored. In the current study, using K562 cell lines, the metabolic impact of fiv...
An In-Depth Exploration of Natural and Herbal Tooth Whitening Agents: Efficacy, Safety, and Clinical Applications [0.03%]
天然和草本牙齿美白剂的深度探索：疗效、安全性和临床应用
Sowmya Halasabalu Kalgeri,SunilKumar Bheemasamudra Balaraj,Vidya G Doddawad et al.
Sowmya Halasabalu Kalgeri et al.
Discoloration refers to the alteration of the original color of an object, resulting in an unpleasant or damaged appearance. Tooth discoloration can occur due to trauma, residual intracanal medicaments or obturating materials, as well as ex...