The Real-World Safety Profile of Hydroxyprogesterone: A Pharmacovigilance Study Based on the Food and Drug Administration's Adverse Event Reporting System Database [0.03%]
羟孕酮的现实世界安全性特征：基于美国食品药品监督管理局不良事件报告系统数据库的药物流行病学研究
Likun Ding,Danjun Ren,Meiyou Liu et al.
Likun Ding et al.
Objective: This study aimed to explore the spectrum of adverse events associated with hydroxyprogesterone and provide a comprehensive understanding of the drug's safety profile based on the Food and Drug Administration's ...
A Novel Ruthenium(II) Complex and its Synergistic Anti-Leukemia Activity with GidA Protein via Dual-Pathway Apoptosis [0.03%]
一种新型钌(II)配合物及其与GidA蛋白协同作用的抗白血病活性的双重凋亡途径研究
Antony K T Infanta S,Thandeeswaran Murugesan,Anand Raj Dhanapal et al.
Antony K T Infanta S et al.
This study demonstrates the effective anticancer activity of a semi-synthetic complex integrating the GidA protein and the ruthenium(II) complex against K562 human leukemia cells. Monotherapy evaluation revealed exceptional cytotoxicity, wi...
Development and Validation of a Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry Method for the Determination of Alpelisib, a Novel Phosphatidylinositol 3-Kinase Inhibitor, and Its Application to a Pharmacokinetic Study in Mice [0.03%]
一种新型磷脂酰肌醇-3-激酶抑制剂艾美司汀的液相色谱-串联质谱分析方法的建立及验证及其在小鼠药代动力学研究中的应用
Abhishek Dixit,Arunava Das
Abhishek Dixit
Alpelisib (BY719) is a phosphoinositide-3-kinase inhibitor that specifically targets phosphoinositide-3-kinase-alpha. This enzyme is part of the phosphoinositide-3-kinase/α-serine/threonine-protein kinase/mammalian target of rapamycin sign...
Astragalus Polysaccharide Alleviates Oxidative Stress Injury through Modulation of the Nrf2/HO-1 Axis in the Striatum of Cerebral Ischemic Rats [0.03%]
黄芪多糖通过调节Nrf2/HO-1轴缓解脑缺血大鼠纹状体氧化应激损伤
Qi Wu,Jinzhong Ni,Hui Teng et al.
Qi Wu et al.
Objective: Astragalus polysaccharide (APS) has therapeutic potential for neurodegenerative diseases; however, its specific mechanism of action against ischemic stroke (IS) requires further elucidation. This study aimed to...
Comparative Biochemical and Functional Characterization of a Novel Human Fibrinogen Concentrate (BT524) and Established Plasma-Derived Fibrinogen Concentrates [0.03%]
新型人纤维蛋白原浓缩物(BT524)与 established 天然来源纤维蛋白原浓缩物的生化和功能性特征比对研究
Michaela Bergmann,Daniela Rübsamen,Steffen Kistner
Michaela Bergmann
Background: Human fibrinogen concentrate is used as replacement therapy for congenital and acquired fibrinogen deficiencies. Despite similar manufacturing principles, compositional differences among products may affect cl...
Preclinical Assessment and Tissue Distribution of Vodobatinib, a Third Generation BCr-Abl 1 Inhibitor [0.03%]
vadotinib的药代动力学和组织分布研究
Sandeep Kaddare,Rama Murthi Bestha,Niranjan Veerla et al.
Sandeep Kaddare et al.
Vodobatinib (K0706) is a novel, orally bioavailable Bcr-Abl 1 tyrosine kinase inhibitor designed to overcome resistance mutations such as T3151 in chronic myeloid leukemia. While its clinical efficacy and safety are under investigation, the...
Ellagic Acid Attenuates Doxorubicin-induced Cardiomyocyte Ferroptosis Via Nuclear Factor Erythroid 2-Related Factor 2 Signaling [0.03%]
ellagic酸通过核因子erythroid 2相关因子2信号通路减轻多柔比星诱导的心肌细胞铁死亡
Rong Li,Zhong Cheng,Wei Li
Rong Li
Doxorubicin, a widely used chemotherapeutic agent, is clinically limited by its dose-dependent cardiotoxicity, in which cardiomyocyte ferroptosis has recently been identified as a critical pathogenic mechanism. Consequently, targeting myoca...
Effects of Sex and Fed State Differences on the Pharmacokinetics of Drugs in Humans [0.03%]
性别和禁食状态对人类药物动力学影响的研究进展
Omaimah Najib,Naji Najib,Nasir Mohammed Idkaidek
Omaimah Najib
Background: Sex and fed state are critical factors influencing drug pharmacokinetics, potentially affecting efficacy and safety. This study evaluates the impact of sex and food intake on key pharmacokinetics parameters-ma...
Protocatechuic Acid Ethyl Ester Protects Against Doxorubicin-induced Cardiotoxicity in Rats [0.03%]
乙基棓酸酯对多柔比星致大鼠心肌损伤的保护作用研究
Leila Safaeian,Maryam Farsiabi,Zahra Haghighatian et al.
Leila Safaeian et al.
Background: Doxorubicin, an anti-neoplastic agent, is linked with a risk of cardiotoxicity following acute or cumulative doses. Protocatechuic acid ethyl ester, as a natural phenolic acid derivative, inhibits a prolyl hyd...
Synergistic Effects of Curcumin and Temozolomide in Overcoming Glioblastoma Drug Resistance through Regulation of O6-Methylguanine-DNA Methyltransferase, Mismatch Repair, and Poly(Adenosine Diphosphate Ribose) Polymerase 1 [0.03%]
姜黄素和替莫唑胺通过调节O6-甲基鸟嘌呤-DNA甲基转移酶、错配修复和多（腺苷二磷酸）核糖聚合酶1来克服胶质母细胞瘤的药物抗性方面的协同作用
Masoud Sohrabi,Amir Valizadeh,Mehran Molavand et al.
Masoud Sohrabi et al.
Glioblastoma is one of the most frequently seen cancer types in the central nervous system, which is associated with drug resistance and high mortality rates. Curcumin demonstrates significant anticancer potential by inhibiting crucial proc...