Intramolecular Interactions of Twenty-Eight Amide Derivatives with the C-ALB Kinase using a Theoretical Model as a Therapeutic Alternative to Treat Cancer [0.03%]
基于理论模型的C-ALB蛋白激酶与二十八种酰胺衍生物的分子内相互作用研究及其抗癌应用前景
Marcela Rosas-Nexticapa,Magdalena Alvarez-Ramirez,Maria Virginia Mateu-Armad et al.
Marcela Rosas-Nexticapa et al.
Several studies have shown that some drugs can slow the growth of cancer cells by inhibiting the c-Abl kinase. However, some of these drugs can cause side effects such as gynecomastia, pulmonary toxicity, and lentiginosis, among others. In ...
Treatment of K562 Cells with ABL Kinase Inhibitors Reveals Differential Metabolic Profiles [0.03%]
ABL激酶抑制剂处理K562细胞揭示不同的代谢谱型
Pranay Renukuntla,Sai Charitha Mullaguri,Divya Presingu et al.
Pranay Renukuntla et al.
ABL kinase inhibitors have transformed the clinical management of chronic myelogenous leukemia; yet, the metabolic consequences of their use remain largely unexplored. In the current study, using K562 cell lines, the metabolic impact of fiv...
An In-Depth Exploration of Natural and Herbal Tooth Whitening Agents: Efficacy, Safety, and Clinical Applications [0.03%]
天然和草本牙齿美白剂的深度探索：疗效、安全性和临床应用
Sowmya Halasabalu Kalgeri,SunilKumar Bheemasamudra Balaraj,Vidya G Doddawad et al.
Sowmya Halasabalu Kalgeri et al.
Discoloration refers to the alteration of the original color of an object, resulting in an unpleasant or damaged appearance. Tooth discoloration can occur due to trauma, residual intracanal medicaments or obturating materials, as well as ex...
Anticancer Activity of Alectinib through Hydroxypropyl-β-Cyclodextrin Complexation: In Vitro Evaluation on A549 Lung Cancer Cells [0.03%]
羟丙基-β-环糊精包合作用增强Alectinib抗肺癌A549细胞活性作用研究
Muathe Najim,Israa Al-Ani,Ibraheem Al-Deeb et al.
Muathe Najim et al.
Alectinib is an effective inhibitor of anaplastic lymphoma kinase utilized in the treatment of anaplastic lymphoma kinase-positive non-small-cell lung cancer. Nonetheless, its limited solubility in water restricts its therapeutic effectiven...
Evaluation of the Migrastatic Properties of Selective MMP-2 Inhibitors in Colorectal Cancer: An In Ovo Approach [0.03%]
结直肠癌选择性MMP-2抑制剂迁移静力特性的评估：一种ovo方法
Nikunj Parekh,Mansi Patel,Praysha Patel et al.
Nikunj Parekh et al.
Colorectal cancer accounts for about 10% of all cancer diagnoses and is the second leading cause of cancer-related death. Until the cancer has progressed to an advanced stage, colorectal cancer typically shows no symptoms. The medications c...
Protective Effect of Boldine Against Diclofenac-Induced Renal Damage in Rats [0.03%]
小檗碱对diclofenac所致大鼠肾损伤的保护作用研究
Luísa Nathália Bolda Mariano,Heloísa Roberti Cristofolini,Rita de Cássia Vilhena da Silva et al.
Luísa Nathália Bolda Mariano et al.
This study investigated the protective effect of alkaloid boldine against diclofenac-induced kidney damage in normotensive female rats. Animals were divided into three groups: naive, vehicle+diclofenac (50 mg/kg), and boldine+diclofenac (bo...
Gallic Acid Induces Apoptosis in Oral Squamous Cell Carcinoma via PI3K/AKT/mTOR Pathway Inhibition and PTEN Upregulation: an In Vitro Study [0.03%]
原花青酸通过抑制PI3K / AKT / mTOR途径和上调PTEN在体外诱导口腔鳞状细胞癌凋亡
Sanaz Helli,Armin Heidari,Armin Tafvizi et al.
Sanaz Helli et al.
Oral squamous cell carcinoma is one of the most common head and neck cancers, which is associated with drug resistance and high mortality rates. The PI3K/AKT/mTOR pathway plays a crucial role in the survival, growth, and metastasis of cance...
Investigating the Protective Role of Vitamin D Supplementation on Cyclophosphamide-Induced Liver Enzyme Alterations in Adult Male Rats [0.03%]
调查维生素D补充剂对环磷酰胺诱导的成年雄性大鼠肝酶改变的保护作用
Tania Nazem,Ali Hosseini-Sharifabad,Mohammad Reza Mofid et al.
Tania Nazem et al.
Cyclophosphamide is known to cause liver dysfunction. This study investigated the protective role of vitamin D supplementation against cyclophosphamide -induced liver dysfunction in adult male rats. The rats receiving cyclophosphamide were ...
Diosgenin Enhances the Sensitivity to Methotrexate Through Oxidative DNA Damage in Saos-2 Osteosarcoma Cancer Cells [0.03%]
薯蓣皂苷通过氧化性DNA损伤增强骨肉瘤细胞株Saos-2对甲氨蝶呤的敏感性
Hadi Ghobadi,Amir Valizadeh,Mohsen Dashti et al.
Hadi Ghobadi et al.
Previously, diosgenin, a steroidal saponin, has demonstrated therapeutic potential for osteosarcoma. However, the underlying mechanisms still remain unknown.This study was designed to investigate the impact of diosgenin on methotrexate-medi...
Resveratrol Sensitizes Temozolomide-Resistant Glioblastoma Cells Through Mitogen-Activated Protein Kinase Pathway Inhibition and P-Glycoprotein Modulation [0.03%]
白藜芦醇通过抑制丝裂原活化蛋白激酶途径和调节P-糖蛋白使替莫唑胺耐药的胶质母细胞瘤细胞重新敏感化
Maede Rezaie,Mohammad Nasehi,Dariush Shanehbandi et al.
Maede Rezaie et al.
Glioblastoma multiforme continues to pose a major therapeutic challenge due to its high level of treatment resistance and poor prognosis. Temozolomide is a standard chemotherapeutic agent, but resistance significantly limits its clinical ef...