Development and Validation of a Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry Method for the Determination of Alpelisib, a Novel Phosphatidylinositol 3-Kinase Inhibitor, and Its Application to a Pharmacokinetic Study in Mice
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Alpelisib (BY719) is a phosphoinositide-3-kinase inhibitor that specifically targets phosphoinositide-3-kinase-alpha. This enzyme is part of the phosphoinositide-3-kinase/α-serine/threonine-protein kinase/mammalian target of rapamycin signaling pathway, which... ...
