The potential of antisense oligonucleotide therapies for inherited childhood lung diseases [0.03%]
反义寡核苷酸疗法治疗遗传性儿童肺病的潜力
Kelly M Martinovich,Nicole C Shaw,Anthony Kicic et al.
Kelly M Martinovich et al.
Antisense oligonucleotides are an emerging therapeutic option to treat diseases with known genetic origin. In the age of personalised medicines, antisense oligonucleotides can sometimes be designed to target and bypass or overcome a patient...
Preserved in vitro immunoreactivity in children receiving long-term immunosuppressive therapy due to inflammatory bowel disease or autoimmune hepatitis [0.03%]
自身免疫性肝炎或炎症性肠病长期接受免疫抑制治疗的儿童体外免疫反应性保存情况
Teresa Schleker,Eva-Maria Jacobsen,Benjamin Mayer et al.
Teresa Schleker et al.
Background: Children with inflammatory bowel disease (IBD) or autoimmune hepatitis (AIH) are at risk for severe infections. This is partially a result of their chronic disease condition but, moreover, a side effect of the...
Concepts for a therapeutic prolongation of nephrogenesis in preterm and low-birth-weight babies must correspond to structural-functional properties in the nephrogenic zone [0.03%]
治疗性延长早产和低出生体重婴儿肾生成的方法必须符合肾生成区的结构-功能特性
Will W Minuth
Will W Minuth
Numerous investigations are dealing with anlage of the mammalian kidney and primary development of nephrons. However, only few information is available about the last steps in kidney development leading at birth to a downregulation of morph...
The BPD trio? Interaction of dysregulated PDGF, VEGF, and TGF signaling in neonatal chronic lung disease [0.03%]
BPD三角？新生儿慢性肺病中失调的PDGF、VEGF和TGF信号间的相互作用
Prajakta Oak,Anne Hilgendorff
Prajakta Oak
The development of neonatal chronic lung disease (nCLD), i.e., bronchopulmonary dysplasia (BPD) in preterm infants, significantly determines long-term outcome in this patient population. Risk factors include mechanical ventilation and oxyge...
Transcatheter atrial septal defect closure in an infant (body weight 6.4 kg) using the GORE CARDIOFORM septal occluder (GCSO) [0.03%]
使用戈尔心内间隔闭合器(GCSO)封堵婴儿(体重6.4kg)房间隔缺损的经皮介入治疗
Roman Scheidmann,Thomas Paul,Matthias Sigler
Roman Scheidmann
Introduction: Transcatheter closure has become the treatment of choice for secundum atrial septal defects (ASD II), but particularly in small children, there is concern regarding procedure-related complications. ...
Estimated prevalence of potentially damaging variants in the leptin gene [0.03%]
估计可能导致蛋白质功能丧失的瘦素基因变异的携带者频率
Adriana Nunziata,Guntram Borck,Jan-Bernd Funcke et al.
Adriana Nunziata et al.
Background: Mutations in the leptin gene (LEP) can alter the secretion or interaction of leptin with its receptor, leading to extreme early-onset obesity. The purpose of this work was to estimate the prevalence of heteroz...
Autism spectrum disorder and Li-Fraumeni syndrome: purely coincidental or mechanistically associated? [0.03%]
自闭症谱系障碍和利-弗劳梅尼综合征：纯粹的偶然性还是机制上的关联？
Michaela Kuhlen,Julia Taeubner,Dagmar Wieczorek et al.
Michaela Kuhlen et al.
Background: Autism spectrum disorders (ASDs) are neurodevelopmental disorders with impaired social interactions and communication and restrictive, repetitive patterns of behaviors, interests, and activities. A recent epid...
The molecular pathophysiology of chronic non-bacterial osteomyelitis (CNO)-a systematic review [0.03%]
慢性非细菌性骨髓炎(CNO)的分子病理生理学-系统评价
Sigrun Ruth Hofmann,Franz Kapplusch,Katrin Mäbert et al.
Sigrun Ruth Hofmann et al.
Chronic non-bacterial osteomyelitis (CNO) belongs to the growing spectrum of autoinflammatory diseases and primarily affects the skeletal system. Peak onset ranges between 7 and 12 years of age. The clinical spectrum of CNO covers sometimes...
Abstracts of the 52nd Workshop for Pediatric Research : Frankfurt, Germany. 27-28 October 2016 [0.03%]
第五届儿科研究会议摘要法兰克福（德国）2016年10月27-28日
Rhea van den Bruck,Patrick P Weil,Thomas Ziegenhals et al.
Rhea van den Bruck et al.
Pediatric precursor B acute lymphoblastic leukemia: are T helper cells the missing link in the infectious etiology theory? [0.03%]
儿童前B细胞急性淋巴细胞白血病：辅助T细胞是否是感染病因学理论中缺失的环节？
Simone Bürgler,David Nadal
Simone Bürgler
Precursor B acute lymphoblastic leukemia (BCP-ALL), the most common childhood malignancy, arises from an expansion of malignant B cell precursors in the bone marrow. Epidemiological studies suggest that infections or immune responses to inf...