Role of second-hand smoke (SHS)-induced proteostasis/autophagy impairment in pediatric lung diseases [0.03%]
二手烟诱导的蛋白质稳态/自噬障碍在儿童肺疾病中的作用
Neel Patel,Christopher D Trumph,Manish Bodas et al.
Neel Patel et al.
Background: Exposure to second-hand tobacco smoke (SHS) is one of the prime risk factors for chronic lung disease development. Smoking during pregnancy may lead to birth defects in the newborn that include pulmonary dysfu...
Amelie Stritzke,Sumesh Thomas,Harish Amin et al.
Amelie Stritzke et al.
Background: The developmental origin of health and disease concept identifies the brain, cardiovascular, liver, and kidney systems as targets of fetal adverse programming with adult consequences. As the limits of viabilit...
Acquisition and adaptation of the airway microbiota in the early life of cystic fibrosis patients [0.03%]
囊性纤维病患者生命早期呼吸道微生物群的获取和适应
Sébastien Boutin,Alexander H Dalpke
Sébastien Boutin
Cystic fibrosis (CF) is a genetic disease in which bacterial infections of the airways play a major role in the long-term clinical outcome. In recent years, a number of next-generation sequencing (NGS)-based studies aimed at deciphering the...
Neutrophil plasticity enables the development of pathological microenvironments: implications for cystic fibrosis airway disease [0.03%]
中性粒细胞的可塑性促进了病理微环境的发展：其在囊性纤维化气道疾病中的作用及意义
Camilla Margaroli,Rabindra Tirouvanziam
Camilla Margaroli
Introduction: The pathological course of several chronic inflammatory diseases, including cystic fibrosis, chronic obstructive pulmonary disease, and rheumatoid arthritis, features an aberrant innate immune response domin...
Severe changes in colon epithelium in the Mecp2-null mouse model of Rett syndrome [0.03%]
甲基 CpG 结合蛋白 2 基因缺失型小鼠结肠上皮的病理改变
Pamela Millar-Büchner,Amber R Philp,Noemí Gutierrez et al.
Pamela Millar-Büchner et al.
Background: Rett syndrome is best known due to its severe and devastating symptoms in the central nervous system. It is produced by mutations affecting the Mecp2 gene that codes for a transcription factor. Nevertheless, e...
Wilms' tumor susceptibility: possible involvement of FOXP3 and CXCL12 genes [0.03%]
Wilm's瘤的发病相关基因FOXp3和CXCL12的研究进展
Patricia Midori Murobushi Ozawa,Carolina Batista Ariza,Roberta Losi-Guembarovski et al.
Patricia Midori Murobushi Ozawa et al.
Background: Wilms' tumor is an embryonal neoplasm of the kidney that accounts for approximately 6 % of all childhood tumors. The chemokine CXCL12 (C-X-C chemokine ligand 12) and its ligand CXCR4 (C-X-C chemokine receptor ...
Katinka Karenberg,Hannes Hudalla,David Frommhold
Katinka Karenberg
Impaired cellular innate immune defense accounts for susceptibility to sepsis and its high morbidity and mortality in preterm infants. Leukocyte recruitment is an integral part of the cellular immune response and follows a well-defined casc...
Linking bronchopulmonary dysplasia to adult chronic lung diseases: role of WNT signaling [0.03%]
早产儿支气管肺发育不良与成人慢性肺病的关系：WNT信号通路的作用
Chiharu Ota,Hoeke A Baarsma,Darcy E Wagner et al.
Chiharu Ota et al.
Bronchopulmonary dysplasia (BPD) is one of the most common chronic lung diseases in infants caused by pre- and/or postnatal lung injury. BPD is characterized by arrested alveolarization and vascularization due to extracellular matrix remode...
The experience of canakinumab in renal amyloidosis secondary to Familial Mediterranean fever [0.03%]
Canakinumab治疗继发于周期热的肾淀粉样变的经验报告
Betul Sozeri,Nesrin Gulez,Malik Ergin et al.
Betul Sozeri et al.
Introduction: Familial Mediterranean fever (FMF) is an autosomal recessive disease characterized by self-limited recurrent attacks of fever and serositis. Patients may develop renal amyloidosis. Colchicine prevents attack...
Molecular biology of the gut [0.03%]
肠道分子生物学
Hassan Y Naim,Klaus-Peter Zimmer,Buford Nichols
Hassan Y Naim