Multiple-breath washout at 12 months of age reveals lung function impairments in preterm infants with bronchopulmonary dysplasia [0.03%]
12月龄早产儿多重呼吸冲洗法检测提示支气管肺发育不良患儿存在肺功能障碍
Isabell Ricklefs,Elisa Grützner,Hannah Wedman et al.
Isabell Ricklefs et al.
Background: Bronchopulmonary dysplasia (BPD) is a major complication of preterm birth and may lead to long-term respiratory morbidity. Early measurements of impaired lung function are needed to guide the development of pr...
Gut-brain-immune interactions in neonatal hypoxic-ischemic brain injury [0.03%]
新生儿缺氧缺血性脑损伤中的肠-脑-免疫相互作用
Josephine Herz,Ivo Bendix,Frederick Orywal et al.
Josephine Herz et al.
Background: Neonatal hypoxia-ischemia (HI) is the leading cause of childhood mortality and neurodevelopmental disability. Despite therapeutic hypothermia as the only clinically established treatment to date, outcomes rema...
Subcutaneous infliximab as a maintenance option in pediatric IBD: a real-world cohort including younger and lower-weight children [0.03%]
儿科IBD患儿皮下注射英夫利昔单抗维持治疗的疗效分析：包括年龄较小和体重较轻的儿童的真实世界队列研究
Neele Ridder,Johanna Overberg,Laura Kalveram et al.
Neele Ridder et al.
Background: Subcutaneous infliximab (SC-IFX) offers an alternative to intravenous infliximab (IV-IFX) in adults with inflammatory bowel disease (IBD), but evidence in children is scarce. This study reports treatment persi...
Untargeted metabolomics reveals distinct metabolic profiles in MUT-type methylmalonic acidemia [0.03%]
未靶向代谢组学揭示了MUT型甲基丙二酸血症的明显代谢特征
Shuruq Alsuhaymi,Reem H AlMalki,Maha Al Mogren et al.
Shuruq Alsuhaymi et al.
Background: Methylmalonic acidemia (MMA), the most prevalent type of inherited metabolic disorder, is inherited in an autosomal recessive pattern due to MUT gene mutations that impair methylmalonyl-CoA mutase (MCM) enzyme...
Diagnostic value of basic and extended procedures in pediatric fever of unknown origin - results of a nation-wide surveillance study [0.03%]
儿童不明原因发热的基本和扩展诊断程序的诊断价值——全国监测研究结果
Mira Katarina Bienioschek,Alice Lejeune,Gonza Ngoumou et al.
Mira Katarina Bienioschek et al.
Background: Pediatric fever of unknown origin (FUO) remains a major diagnostic challenge encompassing infectious, autoimmune and autoinflammatory as well as malignant diseases. Despite improved diagnostical procedures, no...
The impact of central venous catheter use on long-term growth and neurobehavioral outcome in preterm children born < 29 weeks of gestation [0.03%]
极低胎龄儿出生时妊娠不足29周者使用中心静脉导管对其长期生长及神经行为结局的影响
Christine Silwedel,Jana Retzmann,Ingmar Fortmann et al.
Christine Silwedel et al.
Background: Preterm infants often receive central venous catheters (CVCs) for parenteral nutrition during initial enteral feeding advancement. Whether the use of CVCs promotes growth and neurodevelopmental outcomes is cur...
Cardiomyopathy and mitochondrial encephalomyopathy in a female child associated with a heterozygous X-linked AIFM1 variant [0.03%]
与异质性X染色体链霉亲和素相关的心肌病和线粒体脑肌病的女性儿童病例报告
Christoph Sandmann,Swathi Gudapati,Johannes A Mayr et al.
Christoph Sandmann et al.
Background: AIFM1 encodes the X-linked oxidoreductase 'apoptosis-inducing factor 1, mitochondrial' that mediates caspase-independent programmed cell death and is involved in redox metabolism. To date, cardiac involvement ...
Post-intensive care sequelae after severe bacterial infections in previously healthy children [0.03%]
先前健康的儿童发生严重细菌感染后的重症监护后遗症
S C Goretzki,C Held,S Tschirner et al.
S C Goretzki et al.
Background: Severe complications of common community-acquired infections can necessitate pediatric intensive care even in previously healthy children. While survival after pediatric intensive care has improved, data on lo...
Intersectionality of early developmental risks and resilience after preterm birth [0.03%]
早产儿发育早期风险的交叉性及其韧性发展的相关因素
Julia Jäkel,Janika Ludwig,Britta Hüning et al.
Julia Jäkel et al.
The period from conception through preschool age represents a critical developmental window for both microbiome and brain. During this time, several modifiable factors may influence development via the gut-brain axis, including the mode of ...
Victoria Pradler,Clyde J Wright,Nazanin Kazemi-Butterfield et al.
Victoria Pradler et al.
Background: While advancements in neonatal intensive care have significantly improved the survival of preterm infants, inflammation-related complications continue to be a major factor in short- and long-term morbidity, es...