Opinion: Gavage Administration of MXene as a Route-Specific Alternative to Intravenous Injection into the Bloodstream of Laboratory Animals for Reducing Systemic Nanotoxicity Risks in Immunosuppression and Post-Transplantation Models with Bile Acid Modification [0.03%]
Opinion: 以胆酸修饰的二硫化钼为模型，MXene灌胃给药可作为静脉注射入实验动物血液的替代途径，用于免疫抑制和移植后模型的全身纳米毒性风险评估
Alireza Rafieerad,M Akif Rahman,Ahmad Amiri
Alireza Rafieerad
Intravenous injection of engineered material dispersions into the bloodstream of laboratory animals has been a popular method for in vivo immunosuppression. It is also one of the primary approaches for delivering immunosuppressive and anti-...
From Bench to Bedside: A Pilot Clinical Study on NANOTEX Bone Graft for Fibula Onlay Augmentation in Mandibular Reconstruction [0.03%]
纳米纤维素颗粒骨移植材料颞下颌关节区增强的临床研究试点试验
Anna Serene Babu,Arjun Krishnadas,Manju Vijayamohan et al.
Anna Serene Babu et al.
Mandibular continuity defects following tumor resection or trauma present significant reconstructive challenges, particularly for subsequent dental rehabilitation. While the fibula free flap remains the gold standard, its limited vertical h...
Bioengineered 3D hPSC-Cholangiocyte Ducts With Physiological Signals for Biliary Disease Modeling [0.03%]
具有生理信号的生物工程化三维人多能干细胞源胆管类器官用于胆道疾病模型
Britney Tian,Mina Ogawa,Manami Kondo et al.
Britney Tian et al.
The progression of intrahepatic biliary diseases remains poorly understood, underscoring the urgent need to develop physiologically relevant human intrahepatic cholangiocyte disease models. Current approaches lack the complexity and through...
Scalable Production of Multi-Source Hybrid Biomimetic Exosomes Co-Loaded with Therapeutic Plasmids for Treatment of High-Altitude Pulmonary Edema [0.03%]
一种可规模化制备多功能仿生外泌体的新方法及其治疗高原肺水肿的潜力
Sujia Si,Hong Wang,Ya Xu et al.
Sujia Si et al.
Exosomes show therapeutic promise but face limitations in simultaneous targeting and potency. While hybrid exosome strategies combining multiple cell components can address this, current methods rely on native exosome extraction and drug lo...
The Floor-Ceiling-Chip, or 2 × 2D = Pseudo-3D-Approaching 3D Cell Morphology and Organization between Two Opposing 2D Substrates with Cell-Adhesive Protein Micropatterns [0.03%]
地板-天花板微芯片：在两端具有细胞黏附蛋白微图案的二维基质之间接近三维的细胞形态和结构研究
Urandelger Tuvshindorj,Francesca Giacomini,Esra Güben Kaçmaz et al.
Urandelger Tuvshindorj et al.
In this proof-of-concept study, we develop a novel 3D cell patterning and culture platform. The "Floor-Ceiling-Chip" (FC-Chip) simply consists of two opposing 2D substrates in the form of ion track-etched membranes, creating a pseudo-3D mic...
Self-powered Wearable Humidity Sensor for Accurate Respiratory Monitoring [0.03%]
用于精确呼吸监测的自供电可穿戴湿度传感器
Wei Zheng,Yanyu Chen,Jingyu Nie et al.
Wei Zheng et al.
Two-dimensional transition metal carbides are promising materials for humidity sensing because of their excellent hydrophilicity and metallic conductivity. However, the inherent self-restacking and weak interactions between the nanosheets u...
Skin-Inspired MXene@PEDOT:PSS/Bacterial Cellulose Janus Film for Enhanced Skin Bioelectronics and Accelerated Wound Healing [0.03%]
一种用于增强皮肤生物电子设备和加速伤口愈合的仿生MXene@PEDOT:PPS/细菌纤维素Janus膜
Jingwen Zhang,Zeqian Wang,Bingjie Mai et al.
Jingwen Zhang et al.
Recent advancements in skin bioelectronics have significantly transformed personalized daily healthcare monitoring and wound management. Consequently, the development of advanced smart wound-dressing systems, such as bioelectronics-integrat...
Model-Driven Optimization of Subcutaneous Polymer Prodrugs Achieves Cancer Remission in Mice [0.03%]
基于模型的优化使聚合物前药经皮给药的小鼠癌症得到缓解
Anne Rodallec,Randy Lee,Jingming Cao et al.
Anne Rodallec et al.
The limitations of chemotherapy (e.g., toxicities, limited efficacy) have led to the development of nanocarriers for drug delivery to improve pharmacokinetics (PK) and therapeutic outcomes. However, optimizing dosing regimens remains challe...
Paracrine Factor Local Gradient-Generating System for Engineering Perfusable Vascularized Hepatocyte Tissues with Perfusion-Induced Proliferation [0.03%]
工程血管化肝细胞组织的旁分泌因子局部梯度发生系统及灌注诱导增殖效应
Yen-Hsiang Huang,Tadahiro Yamashita,Ryo Sudo
Yen-Hsiang Huang
Donor organ shortages drive an urgent need for engineered hepatocyte tissues; however, functional vascular integration remains a major bottleneck in liver tissue engineering. Current vascularization strategies struggle to achieve perfusable...
Microfluidic Encapsulation of Genetically Engineered Bone-marrow-derived Mesenchymal Stem Cells for Bone Defect Healing [0.03%]
微流体封装基因工程骨髓源间充质干细胞促进骨缺损修复
Wanchuan Ding,Zhiqiang Luo,Junyi Che et al.
Wanchuan Ding et al.
Mesenchymal stem cells (MSCs) hold significant potential for bone healing. Current efforts focus on enhancing stem cell viability and differentiation potential to improve therapeutic outcomes. Here, we transfected bone MSCs (BMSCs) with RUN...