Mechanically Active Adhesive Hydrogels Driven by Peptide Self-Assembly for Accelerated Healing of Diverse Wounds [0.03%]
由肽自组装驱动的机械活性粘合水凝胶用于加速各种伤口愈合
Zunzhen Ming,Yanxin Xiang,Boya Gui et al.
Zunzhen Ming et al.
Emerging mechanically active hydrogels offer a promising therapeutic strategy for accelerating wound healing by promoting wound contraction. However, existing approaches to drive hydrogel contraction remain limited, and their inherent drawb...
Encapsulation and Controlled Release of Human Spinal Cord Organoid-Derived Extracellular Vesicles for Tissue Patterning in Viscoelastic Hyaluronic Acid Hydrogels [0.03%]
人源脊髓器官球来源的外泌体在透明质酸水凝胶中的封装及递送以实现组织构建
Xingchi Chen,Chang Liu,Garrett McDaniel et al.
Xingchi Chen et al.
Human induced pluripotent stem cells (hiPSCs) can differentiate into various types of central nervous system organoids which are valuable for applications in tissue engineering and injury repair. The secreted extracellular vesicles (EVs) of...
Tomographic Printing in a Chip: A Versatile Platform for Biomimetic 3D Organ-on-Chip [0.03%]
芯片层析打印：仿生三维器官芯片的多功能平台
Riccardo Rizzo,Viola Sgarminato,Felix Wechsler et al.
Riccardo Rizzo et al.
Organ-on-chip (OoC) platforms are increasingly adopted for predictive in vitro testing. However, most remain limited by soft-lithography-derived 2.5D microfluidic architectures and nonphysiological rigid materials, or bioprinting approaches...
Lock-Open: An AND Logic-Gated, Entropy-Driven DNA Nanowalker for Highly Sensitive Detection of UDG and APE1 Activities in Hepatocellular Carcinoma [0.03%]
基于锁互开机制的AND逻辑门控核酸纳米行走器检测肝癌相关酶活性研究
Zongying Li,Liuling Shen,Huaqiang Xie et al.
Zongying Li et al.
Early diagnosis of HCC remains a clinical challenge, with survival strongly dependent on reliable biomarkers and translatable detection tools. Herein, we establish uracil-DNA glycosylase (UDG) and apurinic/apyrimidinic endonuclease 1 (APE1)...
Spatiotemporal Sonodynamic-Nanozymic Therapy for Infected Jawbone Defects [0.03%]
时空声动力-纳米酶疗法治疗感染性下颌骨缺损
Xin Liu,Zifan Zhao,Liujixiang Wang et al.
Xin Liu et al.
Infectious jawbone defects, arising from open fractures, surgical contamination, or hematogenous pathogen spread, represent severe orthopedic complications characterized by concurrent bone loss and chronic infection. Precise control of path...
Targeted Retention of Cationic Liposomes at the Inflamed Blood-Brain Barrier by Incorporating Mesenchymal Stem Cell Membrane [0.03%]
通过掺入间充质干细胞膜使阳离子脂质体在炎性血脑屏障的靶向滞留
Juanjuan Zheng,Hui Liu,Yaosheng Li et al.
Juanjuan Zheng et al.
Blood-brain barrier (BBB) disruption is found in many acute and chronic inflammatory encephalopathies. Timely restoration of BBB integrity is essential for controlling disease progression, especially in ischemic stroke. While various brain-...
A 3D-Printed Vascular-Like Perfusion Tumor-on-a-Chip Recapitulates High-Grade Breast Cancer With in Vivo-Relevant Drug Resistance [0.03%]
一种血管类似灌注芯片肿瘤模型的三维打印仿制高分级乳腺癌及体内相关的药物抗性
Geonhui Lee,Bingjie Sun,Nicholas X Fang et al.
Geonhui Lee et al.
Tumor progression and drug resistance in breast cancer are fundamentally governed by a complex microenvironment, characterized by extreme cell densities and associated nutrient/oxygen gradients. Conventional in vitro models often fail to re...
Sulfur Vacancy-Rich MoS2 Nanodot-Based Hybrid Eye Drops as an Antibiotic-Free Antifungus for Fungal Keratitis Therapy [0.03%]
一种基于硫空位富集的二硫化钼纳米点与眼药水相结合的新型抗菌抗真菌剂用于真菌性角膜炎治疗
Ruixing Liu,Xiwen Geng,Huiying Chen et al.
Ruixing Liu et al.
Fungal keratitis is a highly blinding ocular infection that demands innovative treatment strategies, moving beyond conventional antifungal therapies. In this study, we explore the potential of MoS2 nanodots engineered with sulfur vacancies,...
Phase-Separated Nanoarchitecture of Adhesion-Cytoskeleton Force Coupling Reforms Nuclear Spatiotemporal Posture Conformation and Mechanotransduction of Osteosarcoma on Biofunctional Microarrays [0.03%]
生物功能微阵列上成骨肉瘤的细胞外基质相互作用力耦联相分离纳米结构重塑其时空核力学构象和机械转导机制
Huayu Fan,Xinxin Cui,Yan Hou et al.
Huayu Fan et al.
Osteosarcoma is widely concerned because it is a malignant tumor with a high incidence rate among teenagers. Although some chemical, physical, and synergetic technologies have been developed to treat malignant osteosarcoma, molecular mechan...