Decellularized Extracellular Matrix Scaffolds to Engineer the Dormant Landscape of Microscopic Colorectal Cancer Liver Metastasis [0.03%]
脱细胞基质支架用于工程化微观结直肠癌肝转移的休眠景观
Sabrina N VandenHeuvel,Lucia L Nash,Abigail J Clevenger et al.
Sabrina N VandenHeuvel et al.
Recurrent liver-metastatic colorectal cancer contributes to high mortality. Recurrence occurs when dormant, microscopic residual disease survives initial treatment to escape dormancy. In their dormant, microscopic state within the liver, th...
Injectable Biomimetic Lubricant-PRP Hydrogel with Synergistic Lubrication from In/Ex-Sources for Cartilage Regeneration in Rabbits [0.03%]
一种用于兔软骨再生的仿生可注射润滑型PRP水凝胶的研究
Yongan Lin,Zijian Yan,Jiayi Chen et al.
Yongan Lin et al.
Cartilage regeneration remains a clinical challenge, as existing treatments (including pharmacological and physiological treatments) only alleviate symptoms. This work proposes a novel strategy of in/ex-source synergistic lubrication and de...
Noam Demri,Lise Morizur,Simon Dumas et al.
Noam Demri et al.
Engineering tissues with precise, long-lasting shapes and the capability for mechanical stimulation remains challenging. This study addresses this challenge by developing a next-generation magnetic bioprinting approach to create anisotropic...
Scaffold-Guided Subchondral Bone Repair Enables Endogenous Stem Cell-Driven Cartilage Regeneration in Osteochondral Defects [0.03%]
基于骨支架引导的软骨下骨再生联合干细胞治疗促进骨软骨缺损修复
Yang Liu,Lei Liu,Jiawei Li et al.
Yang Liu et al.
Osteochondral defects involve concurrent damage to cartilage and the subchondral bone. Here, a cell-free scaffold is presented, consisting of a 3D-printed bioceramic base combined with a Gelatin methacryloyl (GelMA)-Kartogenin (KGN) hydroge...
Site-Specific Antibacterial Strategy for Multi-Pathway Treatment of Drug-Resistant Skin Infections [0.03%]
针对耐药性皮肤感染多途径治疗的位点特异性抗菌策略
Lu Tang,Hening Liu,Jingwen Feng et al.
Lu Tang et al.
Drug-resistant skin infections, especially those caused by multidrug-resistant (MDR) bacteria, remain a major public health concern due to the limited efficacy of conventional antibiotics and biofilm-associated tolerance. Herein, a site-spe...
Body Biofluids for Minimally-Invasive Diagnostics: Insights, Challenges, Emerging Technologies, and Clinical Potential [0.03%]
微创诊断中的体液检测：见解、挑战、新兴技术及临床应用前景
Lanka Tata Rao,Chandan Kumar Mandal,Fernando Patolsky
Lanka Tata Rao
Recent advances in diagnostics have accelerated the development of miniaturized wearable technologies for the continuous monitoring of diseases. This paradigm is shifting healthcare away from invasive, centralized blood tests toward decentr...
Engineered Neuro-Regenerative Peptide Hydrogel for Directed Neural Lineage Reprograming and Regeneration of Sciatic Nerve Injury [0.03%]
一种用于定向神经谱系重编程和坐骨神经损伤再生的 engineered 神经再生肽水凝胶
Shubham Garg,Aniket Jana,Sanju Gupta et al.
Shubham Garg et al.
Living systems are distinguished by their ability to self-organization, a phenomenon that drives a range of pattern-forming processes, from sand dunes to cellular assemblies and tissue architectures. Inspired by these natural phenomena and ...
Stem Cells from the Apical Papilla-Laden Microgels in Combination with Mandibular Advancement for Adult Condylar Cartilage Development [0.03%]
联合使用牙髓干细胞和舌骨牵张术促进成人下颌关节软骨再生修复的研究
Shengchao Wang,Chichong Chan,Xinyu Shi et al.
Shengchao Wang et al.
Angle's Class II malocclusion, characterized by mandibular retraction, significantly impacts occlusal function and facial aesthetics. In adults, the limited development potential of the condylar cartilage poses challenges to effective mandi...
Cyclic Peptide-Polymer Conjugate Nanotubes for Delivery of SN-38 in Treatment of Colorectal Cancer Model [0.03%]
用于 colorectal 癌症小鼠模型治疗的 SN-38 输送肽聚合物纳米管
Sophie K Hill,Min Zeng,Santhosh Kalash Rajendrakumar et al.
Sophie K Hill et al.
Cyclic peptide-polymer conjugate nanotubes have been shown to be powerful drug delivery vectors, due to their propensity for dynamic self-assembly, high aspect ratio morphology and structural interchangeability. Building upon previous studi...
A Human Kidney Tubuloid Model of Repeated Cisplatin-Induced Cellular Senescence and Fibrosis for Drug Screening [0.03%]
体外人肾小管细胞模型筛选延缓或逆转衰老和纤维化的化合物
Yuki Nakao,Makiko Mori,Yuta Sekiguchi et al.
Yuki Nakao et al.
In advancing pathophysiological models to assess renal drug responses, kidney organoids derived from human pluripotent stem cells mark notable progress. However, replicating aging- and senescence-related pathologies remains a challenge. In ...