Zichun Zhou,Feng Ouyang,Minzhe Wang et al.
Zichun Zhou et al.
Liver precancerous lesions carry a 60%-80% risk of malignant transformation into early-stage hepatocellular carcinoma (HCC) within 5 years. Oxidative stress is identified as the central pathogenic mechanism driving the malignant transformat...
Structure-Function Correlation of Clinically Inspired Lipid Nanoparticles for Lung and Spleen Targeted mRNA Delivery [0.03%]
Natalia Martinez,Haitao Yu,Joshua Iscaro et al.
Natalia Martinez et al.
Lipid nanoparticles (LNPs) have emerged as a transformative platform for mRNA delivery. However, challenges such as low endosomal escape efficiency remain key barriers in the field. Herein, we systematically investigate the clinically appro...
Genetically Encoded In Vivo Ligation-Driven Targeted Drug Delivery System for Oncotheranostics [0.03%]
Anastasiia S Obozina,Alexander V Gopanenko,Svetlana D Zvereva et al.
Anastasiia S Obozina et al.
Nanotechnology is transforming cancer diagnostics and treatment through targeted drug delivery. However, the clinical use of nanoparticles faces major challenges, including inconsistent chemical synthesis, low effectiveness, low delivery ef...
Magnesium and Zinc Co-Functionalized Nano-Structured Titania Surfaces Over Titanium Implants for Enhanced In Vitro and In Vivo Performance [0.03%]
Sreya P th,Ann Mary Mathew,Kalimuthu Vignesh et al.
Sreya P th et al.
The current study presents the development of a biomimetic multifunctional nano-titania interface over Ti metal with co-functionalization of Magnesium (Mg) and Zinc (Zn) ions by a simple chemical treatment approach for improved surface and ...
Photothermal-Immunomodulatory Nanohydrogel Eradicates Infection and Accelerates Bone Regeneration in Infected Defects [0.03%]
光热免疫调节纳米水凝胶可根除感染并促进感染缺损中的骨再生
Tiantian Zhan,Zhurun Fang,Jiayi Xu et al.
Tiantian Zhan et al.
The management of infected bone defects remains difficult due to the dual challenges of stubborn infection and impaired regeneration. To overcome these issues, a multifunctional nanocomposite hydrogel (PNPs@RuO2@HAP@Gel) is created by combi...
Highly Sensitive Oxidation-Resistant Degradable Janus Piezoresistive Electronic Skin for Sustainable Wearable Electronics [0.03%]
一种用于可持续穿戴电子设备的高灵敏耐氧化降解式压阻电子皮肤
Joon Kim,Mohammad Zarei,Deristisya Zahra et al.
Joon Kim et al.
Wearable sensors enable fast and accurate monitoring of physiological signals, with broad applications in electronic skin (e-skin), biomedical engineering, and human-machine interfaces. However, their proliferation raises concerns about ele...
Modular Platform for Rapidly Investigating Long-Distance Propagation of Human Neural Network Activity [0.03%]
一种模块化平台 可快速研究人类神经网络活动的远距离传播
Megh Dipak Patel,Sailee Sham Lavekar,Ronak Jaisalmeria et al.
Megh Dipak Patel et al.
Biological neural networks exhibit synchronized activity within and across interconnected regions of the central nervous system. Understanding how these coordinated networks are established and maintained may reveal therapeutic targets for ...
Engineering a Self-Defensive Restoration-Tooth Interface via Bioactive nMgO/E-POSS Bulk-Fill Resin Composites for Enhanced Dental Restorations [0.03%]
一种用于增强牙科修复的自防御修复牙齿接口的生物活性nMgO/E-POSS bulk-fill树脂复合材料的设计与构建
Zhongyuan Wu,Yuwei Zhao,Aihua Li et al.
Zhongyuan Wu et al.
Light-curing resin composites (RCs) are widely used for tooth defect restoration. However, challenges such as high polymerization shrinkage and lack of anti-cariogenic activities compromise interfacial integrity and significantly increase r...
Lipid Droplets-Targeted Thermally Activated Delayed Fluorescence Photosensitizer for Photodynamic Therapy-Mediated Ferroptosis: a New Strategy for Tumor Radiosensitization [0.03%]
靶向脂滴热活化延迟荧光光敏剂介导的肿瘤放射增敏铁死亡策略
Shengnan Xu,Xiang Wang,Keru Pu et al.
Shengnan Xu et al.
Radiotherapy (RT) is a fundamental modality in cancer treatment, yet its clinical effectiveness is often limited by the development of tumor radioresistance. Significant lipid droplet (LD) accumulation is identified in radioresistant A549 l...
Molecular Pathway Modulation and Nanotechnology-Based Therapeutic Strategies for Shikonin [0.03%]
基于分子途径调控和纳米技术的龙胆苦素治疗策略研究进展
Haibo Wang,Qiwei Tian,Lu Yang et al.
Haibo Wang et al.
Chinese herbal medicine Radix lithospermi (Lithospermum erythrorhizon), a traditional medicinal herb widely utilized in China, yields Shikonin as a bioactive monomeric compound. Shikonin demonstrates multifaceted pharmacological profiles, e...