GLUT1-Targeted Biomimetic Parishin-Modified Nanoselenium for Organ Protection by Reestablishing Mitochondrial Homeostasis via Anti-inflammatory and Antioxidant Pathways [0.03%]
通过抗炎和抗氧化途径重塑线粒体稳态的器官保护型仿生纳米硒：靶向GLUT1的巴尔申修饰纳米硒
Peng Tang,Siyi Ma,Xiaolin Zhang et al.
Peng Tang et al.
GLUT1-targeted therapy is a promising approach for treating various diseases. However, overcoming the poor competitiveness of glucose-analog ligands to bind glucose molecules is highly challenging. In this study, parishins isolated from Gas...
Electrospinning a Mechanocompatible External Support for the Ross Procedure [0.03%]
用于ROSS手术的机械相容性外部支撑的电纺技术
Thibault Vervenne,Amber Hendrickx,Margaux Schols et al.
Thibault Vervenne et al.
The Ross procedure is the only aortic valve replacement technique that restores long-term survival while maintaining quality-of-life. In the Ross procedure, the patient's own pulmonary valve is placed in aortic position, forming a pulmonary...
NIR-Triggered Hydroxyl Radical Storm: A Novel Phototherapy Nanoplatform for Potent Ferroptosis‑Like Cell Death Induction in Tumors [0.03%]
近红外触发羟基风暴：肿瘤中铁死亡类似细胞诱导的新光疗纳米平台
Lie Li,Chengmei Li,Yubin Zhao et al.
Lie Li et al.
The development of organic photocatalysts holds considerable promise for the oxidation of NADH, thereby disrupting the NADH/NAD+ equilibrium, modulating redox homeostasis, and enhancing treatment of hypoxic tumors. However, there is still a...
Plasmon-Driven Gene Amplification-Integrated Lateral Flow Assay for Ultrafast Diagnosis of Seoul Orthohantavirus [0.03%]
用于快速诊断汉城病毒的等离子体驱动基因扩增集成侧向流动测定法
Sung Eun Seo,Kyung Ho Kim,Kyoung G Lee et al.
Sung Eun Seo et al.
Accurate and rapid nucleic acid detection is vital for the early diagnosis of infectious diseases. Conventional polymerase chain reaction (PCR) offers high sensitivity but is hindered by bulky equipment, long processing times, and the need ...
Organelle-Targeted, ROS-Gated Prochelators for Inhibition of Triple-Negative Breast Cancer via Depleting Exchangeable Copper [0.03%]
靶向细胞器的ROS门控前螯合剂通过耗尽可交换铜抑制三阴性乳腺癌
Chengcheng Wang,Keyu Lu,Qingqing Wang et al.
Chengcheng Wang et al.
The dyshomeostasis of copper has been implicated in a variety of human diseases. However, the selective manipulation of copper flux at the subcellular organelle level remains challenging, which hinders the development of mechanism-guided th...
A Biomimetic Nanoplatform Alleviates Depression via GRP75-Targeted Mitochondria-Associated Endoplasmic Reticulum Membranes Disassembly and Nanozyme-Driven ROS Scavenging [0.03%]
一种仿生纳米平台通过靶向GRP75的线粒体相关内质网膜解组装和类酶催化的ROS清除来缓解抑郁症状
Wenfei Wang,Pengxiang Zhang,Ye Peng et al.
Wenfei Wang et al.
Dysfunction of microglial mitochondria-associated endoplasmic reticulum membranes (MAMs) and excessive oxidative stress are emerging pathological features of depression. Here, we developed P/F-Rg1@M, a macrophage-biomimetic nanomedicine des...
Cellularized Skin Substitute Bioengineering for Regenerative Medicine: Cell Sources, Culture Strategies, and Transition Toward Defined, Xeno-Free Culture Systems [0.03%]
用于再生医学的细胞化皮肤替代品生物工程：细胞来源、培养策略及向明确无异种培养体系的过渡
Gilles Lemaître,Marina Trouillas,Tatiana Vinasco-Sandoval et al.
Gilles Lemaître et al.
The skin provides a model for regenerative medicine, prompting the design of cultured reconstructed tissue substitutes. Translational research and bioengineering have indeed given rise to clinical applications such as the grafting of cultur...
Enhancing Bioavailability of Ultra-High Concentration Antibody Formulations Using Ionic Liquids [0.03%]
使用离子液体提高超高浓度抗体配方的生物利用度
Anujan Ramesh,Metecan Erdi,Shuyang Zhang et al.
Anujan Ramesh et al.
Subcutaneous (SC) delivery of ultra-high concentration antibody formulations (uHCAFs, > 150 mg/mL) is limited by excessive viscosity and poor bioavailability. Here, we present an ionic liquid made with choline and tryptophan (CHAT) as a mul...
Making the Case for Organ-on-Chip Platforms in Long-Acting Therapeutics Development [0.03%]
论持久起效药物开发中器官芯片平台的案例分析
Charlie Gowans,Abdulwahhab Khedr,Panagiotis G Georgiou et al.
Charlie Gowans et al.
Organ-on-chip (OoC) technologies and long-acting therapeutics (LATs) are two rapidly advancing fields that have not yet been meaningfully integrated. This review argues that their convergence represents a significant and timely opportunity....
Spatially Controlled Embedded Bioprinting of Prevascularized Spheroids-Containing Biopatch Enables Functional Skin Regeneration [0.03%]
空间控制的嵌入式生物打印含有预血管化的球体生物贴片使皮肤再生功能化
Minjun Ahn,Gyu Tae Park,Dongjun Lee et al.
Minjun Ahn et al.
Functional vascularization remains a critical challenge in the regeneration of full-thickness skin defects. Here, we present a 3D embedded bioprinting strategy for engineering vascularized biopatches through the precise integration of preva...