Advances in Photoacoustic Imaging for Brain Diseases: Principles, Applications, and Clinical Translation Challenges [0.03%]
Xixi Hu,Haoyang Chang,Shihan Xu et al.
Xixi Hu et al.
The growing prevalence of brain diseases and the limitations of existing imaging techniques highlight the urgent demand for advanced, biocompatible, and high-resolution brain imaging approaches. Photoacoustic imaging (PAI) uniquely integrat...
Bingyue Fu,Dawei Chen,Guohua Wang et al.
Bingyue Fu et al.
Nanomaterials (NMs) have emerged as promising tools for tumor-targeted therapy and gene editing. However, their delivery efficiency is severely limited by the mononuclear phagocyte system (MPS), which rapidly clears them from circulation pr...
Delivery System Based on Akkermansia Muciniphila Loaded Salidroside for the Treatment of Osteoporosis in Zebrafish Model [0.03%]
Jiahui Ma,Jing Ruan,Jia Yi et al.
Jiahui Ma et al.
Glucocorticoid-induced osteoporosis (GIOP) is a frequent cost of dexamethasone (Dex) therapy; salidroside (SAL) shows promise but suffers from rapid clearance and poor oral bioavailability. We present an oral, living co-therapy in which via...
An Integrated Nanozyme-Exosome Platform for Multi-Targeted Therapy of Metabolic-Associated Steatotic Liver Disease [0.03%]
Kun Yu,Xinwei Li,Yingying Liu et al.
Kun Yu et al.
Metabolic-associated steatotic liver disease (MASLD) is a prevalent chronic liver disorder driven by a complex interplay of lipid accumulation, oxidative stress, and inflammation, for which effective targeted therapies remain limited. To ad...
Piezoelectric Surface Charge and Dynamic Stimulation Synergize to Promote Cardiac Myoblast Alignment and Maturation [0.03%]
Rafaela M Meira,Sylvie Ribeiro,Senentxu Lanceros-Mendez et al.
Rafaela M Meira et al.
This work investigates the role of surface charge and synergistic mechano-electrical stimulation of piezoelectric poly(vinylidene fluoride) (PVDF) on the behaviour of H9c2 cardiac cells. H9c2 cells preferentially adhered to poled PVDF sampl...
Shibo Tian,Hailong Xie,Qin Zhong et al.
Shibo Tian et al.
Mitochondria act as central organelles regulating energy metabolism and lipogenesis in adipocytes. Mitochondrial dysfunction and oxidative stress are closely implicated in the pathogenesis of obesity. Therefore, targeting adipose mitochondr...
Chitin Derivative-Based Detachable Microneedles for Effective Treatment of Androgenic Alopecia [0.03%]
Jiaxue Zhang,Yijia Zhang,Ying Yang et al.
Jiaxue Zhang et al.
Androgenic alopecia (AGA) is the most common type of hair loss in clinical practice, which not only compromises scalp physiology but also induces psychological comorbidities. Despite its high prevalence, current therapeutic interventions fo...
Multitalented Hybrid Targeted Nanoconstructs Selectively Repress Survival Genes and Induce Breast Tumor Regression In Vivo [0.03%]
Niladri Haldar,Rajkumar Samanta,Surajit Patra et al.
Niladri Haldar et al.
Dysregulation of survival genes is a significant factor in the development of breast cancer and other cancers. Transcriptional downregulation of these genes offers a promising therapeutic strategy for cancer treatment by inducing apoptosis....
Copper-Collagen Interactions Regulate the Mechanical and Invasive Properties of Tumor Spheroids [0.03%]
Paula Guerrero-López,Jose I Garcia-Peiro,Felipe Hornos et al.
Paula Guerrero-López et al.
Copper is a key trace element with established cytotoxic properties, yet its interactions with the extracellular matrix and their implications for the evolution of 3D culture models remain poorly understood. Here, we study how copper entrap...
Bifunctional Surfaces With Immobilized Antibodies and Bioactive Peptides Mediate Selective Capture and Proliferation of Endothelial Colony-Forming Cells [0.03%]
Hugo A Level,Marc-Antoine Campeau,Mohamed A Elkhodiry et al.
Hugo A Level et al.
Endothelial colony-forming cells (ECFCs) are of significant interest in vascular biomaterials engineering and cell-based therapies for cardiovascular diseases. Efficient isolation and expansion of ECFCs on polymeric surfaces either in vitro...