Modular Control of PEG-Poly(2-Oxazoline) Co-Assembly Enables Tunable Aggregate Properties for Intraocular Pressure Management [0.03%]
Yuji Tanaka,Shohei Morikawa,Shigehito Osawa
Yuji Tanaka
Poly(2-oxazoline) (POx) polymers are hydrophilic and biocompatible materials with tunable physicochemical properties for biomedical use. Postoperative hypotony, which currently lacks approved pharmacological or device-based treatment, requi...
Delivery of Engineered BMP2 circRNA via Biomimetic Nanovesicles Enhances Titanium Implant Osseointegration Through Translation-Controlled Osteogenesis [0.03%]
Yichen Li,Ziyan Guo,Pengyu Zhao et al.
Yichen Li et al.
Although mRNA therapy has achieved favorable outcomes, it still faces limitations such as poor stability and short duration of protein expression. In this study, we utilized a covalently closed circular RNA encoding bone morphogenetic prote...
Cation-Exchange Synthesized Zn-Doped Ag2S Nanostructures for Photothermal and Photodynamic Therapies Across Breast Cancer Subtypes [0.03%]
Harshavardhan Mohan,Satabdi Acharya,Inhee Chung et al.
Harshavardhan Mohan et al.
Photothermal therapy (PTT) and photodynamic therapy (PDT) require nanostructures capable of efficiently converting red-light energy into both heat and reactive oxygen species (ROS). However, simultaneously achieving high photothermal conver...
Precise Synergistic Photoregulation of Dual-Target Gene Expression by Engineering Caged Two-in-One DNA-RNA Nanoframework Based on Near-Infrared Light Uncaging Strategy [0.03%]
Shanyu Cai,Yizhi Man,Jiaojiao Yu et al.
Shanyu Cai et al.
The synergistic regulation of gene expression at spatiotemporal resolution is of great importance for exploring specific gene functions and regulating biological processes. Here, we have designed and developed an engineering caged two-in-on...
Smart Face Masks as Wearable Respiratory Sensors: A Review of Sensor Technologies, Materials, and Future Directions [0.03%]
Negin Faramarzi,Naseeh Backer Kannanthodi,Alice Nicole Casling et al.
Negin Faramarzi et al.
Smart face masks are rapidly evolving into versatile wearable devices capable of simultaneously tracking a variety of physical and biochemical signals for both personal healthcare and environmental monitoring. This review focuses on respira...
Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy [0.03%]
Muhammad Waqas Salim,Wei Zhang,Lyndsey Collins-Praino et al.
Muhammad Waqas Salim et al.
Small extracellular vesicles (sEVs) have emerged as central mediators of intercellular communication in the central nervous system (CNS) and are increasingly recognized for their dual roles in the pathogenesis and treatment of neurodegenera...
Tip-Functionalized Gold Nanorod Micropillar Arrays for Millisecond-Resolved Photothermal Neuromodulation Toward Retinal Prosthetic Applications [0.03%]
Nafis Mustakim,Rory Fitton,Leslie Gunther Cummins et al.
Nafis Mustakim et al.
Photothermal stimulation using plasmonic nanomaterials presents a promising alternative to electrical stimulation in retinal prostheses, addressing various functional limitations associated with electrical methods. However, many phototherma...
Synergistic Thermochemotherapy via Injectable Polyurethane Hydrogel Co-Delivering Cisplatin and 17AAG for Peritoneal Metastasis of Colorectal Cancer [0.03%]
Xiangdong Wang,Nan Sheng,Feng Luo et al.
Xiangdong Wang et al.
Colorectal cancer peritoneal metastasis (CRC-PM) often has poor prognosis after traditional hyperthermic intraperitoneal chemotherapy (HIPEC) due to constraints of respiratory movements, intestinal peristalsis and peritoneum plasma barrier....
Halting Mitochondrial Domino Effect in Acute Liver Injury: Polyphenol-Sr Nanodrugs Attenuate Cell Death and Sterile Inflammation by Combating ROS Burst and Calcium Overload [0.03%]
Min Liu,Shuya Wang,Ruishi Li et al.
Min Liu et al.
Acute liver injury (ALI) is a significant clinical cause of liver failure, potentially occurring at any stage of liver disease and posing a considerable health burden. One prevalent model of ALI stems from acetaminophen (APAP) overdose, whe...
Jacob C Holter,Shashwat S Agarwal,Joseph W Tinapple et al.
Jacob C Holter et al.
The transport function of lymphatic vessels is altered during tissue injury, inflammation, and cancer. Defects in lymphatic function are associated with changes to the biophysical microenvironment, including pressure and flow. However, the ...