Self-Propelling WO3 Nanomotors Restore the Gut-Kidney Axis by Modulating Intestinal Homeostasis in Inflammatory Bowel Disease [0.03%]
WO3纳米发动机通过调节肠道稳态修复肠肾轴以治疗炎症性肠病
Lin Zhang,Yongsheng Du,Xiaojun Dong et al.
Lin Zhang et al.
Inflammatory bowel disease (IBD) was a chronic idiopathic disorder affecting the ileum, rectum, and colon, characterized by substantial disruptions in the gut microbiota that ultimately led to dysbiosis. Such microbial imbalance compromised...
Dual-Functional Microreactor Enabling Hydrogen Therapy and Mild Photothermal Therapy for Osteoarthritis Treatment [0.03%]
用于关节炎治疗的集氢气治疗和微温光热治疗于一体的双重功能微反应器
Zhe Wang,Yuyang Wu,Ze Zhang et al.
Zhe Wang et al.
Osteoarthritis (OA) is a prevalent degenerative joint disorder. Current therapeutic approaches have yielded suboptimal clinical outcomes, primarily due to their inability to effectively eliminate reactive oxygen species (ROS), which are the...
Biphasic Co-Delivery of Curcumin and 5-FU using 3D-Printed Dissolving Microneedles for Skin Cancer Therapy [0.03%]
用于皮肤癌治疗的3D打印溶蚀型微针递送黄酮和5-FU的双相协同给药体系
Rutuja N Meshram,Dimitrios A Lamprou
Rutuja N Meshram
Dissolving microneedle (MN) arrays are a minimally invasive strategy for localized transdermal chemotherapy; however, their translation is limited by drug loading, reproducible dosing, and the difficulty of incorporating chemically distinct...
Biomineralized Multienzyme-Mimicking 2D Nanoplatform Achieves Efficient Redox-Governed Reversal of Tumor Multidrug Resistance [0.03%]
红氧化还原调控的肿瘤多药耐药高效逆转的仿生矿物二维多功能模拟纳米平台
Da-Gui Zhang,Yang Zhang,Hui-Ya Hong et al.
Da-Gui Zhang et al.
Multidrug resistance (MDR) in cancer is driven by hypoxia, elevated antioxidant capacity, and drug efflux. Herein, a universal MDR-reversal nanoplatform based on hyaluronic acid (HA)-templated manganese oxide nanosheets (MH NSs) was develop...
Thrombin-Responsive Multiarmed Nanovesicles for Targeted Delivery of Tissue Plasminogen Activator and MRI-Monitored Thrombolysis [0.03%]
一种用于组织型纤溶酶原激活物靶向投送的凝血酶响应型多臂纳米囊体及其磁共振监测溶栓研究
Yu Huang,Jinlong Zhang,Xuehao Yu et al.
Yu Huang et al.
An ordered therapeutic sequence in which target engagement precedes site-restricted payload delivery provides a conceptual framework for precision thrombolysis. Guided by this process-level logic, we engineered a multiarmed nanovesicle, ter...
Dual-Barrier Remodeling of Solid Tumors by a Selenium-Photothermal Peptide Assembly for NK Cell-Oriented Immunotherapy [0.03%]
硒光热肽组装体双重屏障重修为以自然杀伤细胞为导向的免疫疗法重塑实体肿瘤
Liyuan Peng,Ming Ji,Yuting Kong et al.
Liyuan Peng et al.
Immune resistance in solid tumors is sustained by the coexistence of physical exclusion and immunological suppression, yet biomaterial strategies that coordinately address both barriers remain limited. Here, we report a single-component sel...
Smart Bio-Inspired Sprayable Conductive Hydrogel for Biomedical and Human Motion Monitoring Applications [0.03%]
一种仿生喷雾导电水凝胶及其在生物医学和人体运动监测中的应用
Amarjyoti Mondal,Abhay Srivastava,Aditi Aggarwal et al.
Amarjyoti Mondal et al.
Conventional rigid electronic components often suffer from mechanical mismatch with soft biological tissues, resulting in discomfort, unstable signals, and mechanical failure under repeated deformation. To address these challenges, we prese...
Mitochondria-Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential [0.03%]
线粒体靶向纳米疗法在衰老神经退行性疾病中的前景和临床潜力
Dnyandev G Gadhave,Ashish B Jadhav,Nitin B Waghamode et al.
Dnyandev G Gadhave et al.
Aging is a significant risk factor of neurodegenerative disorders (NDs) such as Huntington's, Alzheimer's, Parkinson's, amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS). Although several clinical, neuroimaging, and biomarker...
ROS-Sensitive Hydrogel With Methotrexate-ss-Oxidized Bletilla striata Polysaccharide Nanoparticles for the Enhanced Treatment of Rheumatoid Arthritis [0.03%]
一种含甲氨蝶呤氧化块菌多糖纳米颗粒的 ROS 敏感水凝胶，用于增强类风湿性关节炎治疗
Rui Ma,Cheng Yuan,Wenbo Huo et al.
Rui Ma et al.
Remodeling the immune microenvironment and scavenging excess reactive oxygen species (ROS) are considered effective strategies for treating rheumatoid arthritis (RA). Methotrexate (MTX), a first-line drug, can correct the imbalance between ...
RVG-Functionalized Liposomal Mollugin: A Targeted Nanotherapy for Spinal Cord Injury [0.03%]
用于脊髓损伤的靶向纳米治疗：功能化的载小草碱胶束化脂质体
Quan Zhou,Imran Ibrahim Shaikh,Jianfeng Wang et al.
Quan Zhou et al.
Spinal cord injury (SCI) remains a major clinical challenge because the inflammatory and oxidative microenvironment drives secondary tissue damage. Although mollugin (Mol) possesses anti-inflammatory, antioxidant, and neuroprotective activi...