Thrombin-Responsive Multiarmed Nanovesicles for Targeted Delivery of Tissue Plasminogen Activator and MRI-Monitored Thrombolysis
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An ordered therapeutic sequence in which target engagement precedes site-restricted payload delivery provides a conceptual framework for precision thrombolysis. Guided by this process-level logic, we engineered a multiarmed nanovesicle, termed tPA@CTG, that in... ...