Skin-Tailored Adhesive Bio-Electrode with Tunable Poisson's Ratio for Stable Electrophysiological Communication [0.03%]
具有可调泊松比的皮肤定制型粘性生物电极，实现稳定的电生理信号传输
Hyun Seok Kang,Sumin Kim,Hyunggwi Song et al.
Hyun Seok Kang et al.
Stretchable electrodes are crucial healthcare device components for electrophysiology signal sensing. Compared to conventional rigid gel electrodes, stretchable electrodes are advantageous for long-term monitoring with superior skin conform...
Clusterzyme-Enabled Oxidative Stress Alleviation and Microglial Polarization Modulation for Efficient Ischemic Stroke Treatment [0.03%]
用于有效缺血性中风治疗的集群酶诱导氧化应激缓解和小胶质细胞极化调节
Lin Zhu,Weijie Zhong,Xuchen Meng et al.
Lin Zhu et al.
Ischemic stroke (IS) presents a significant challenge to global health, as conventional reperfusion strategies aimed at restoring cerebral circulation paradoxically exacerbate neurological damage. This injury primarily results from the exce...
3D Printed Bioactive Mechanical-Adaptive Polyetheretherketone Implants with Non-Invasive Tracking for Immunomodulatory Osseointegration [0.03%]
具有非侵入性追踪功能的3D打印生物活性机械自适应聚醚醚酮植入物实现免疫调节骨整合
Hongyun Ma,Jin Tong,Xiaochen Su et al.
Hongyun Ma et al.
Polyether-ether-ketone (PEEK) has become a much-attracted biomedical implant material in orthopedic surgery, serving as a more biocompatible alternative to conventional metals. However, the inherent bioinert and mismatched mechanical surfac...
The Phase-Transited Lysozyme Coating Modified Small Intestinal Submucosa Membrane Loaded with Calcium and Zinc Ions for Enhanced Bone Regeneration [0.03%]
负载钙锌离子的相变溶菌酶涂层修饰小肠亚黏膜基质膜用于增强骨修复
Yilin Yang,Tianyi Tong,Xin Li et al.
Yilin Yang et al.
Bone defects caused by severe trauma, tumors, infections and diseases remain a global challenge due to limited natural regeneration capacity of bone tissue in large-scale or complex injuries. Guided bone regeneration (GBR) has emerged as a ...
Novel Protein-Rich Bioactive Bioink Stimulates Cellular Proliferation and Response in 3D Bioprinted Volumetric Constructs [0.03%]
新型富含蛋白质的生物活性生物墨水刺激三维生物打印体积构建体中的细胞增殖和反应
Suihong Liu,David Kilian,Anne Bernhardt et al.
Suihong Liu et al.
3D extrusion bioprinting, a promising and widely adopted technology in the emerging field of biofabrication, has gained considerable attention for its ability to fabricate hierarchically structured, native-mimicking tissue substitutes with ...
Bimetallic MnZnSX Nanotheranostics for Self-Activatable Chemo-Immunotherapy of Hepatocellular Carcinoma via H₂S-Triggered Arsenic Prodrug Activation and Binary cGAS-STING Pathway Modulation [0.03%]
用于肝细胞癌的化疗-免疫治疗的自激活双金属MnZnSX纳米诊疗剂通过H₂S触发的砷前药活化和双重cGAS-STING通路调节
WeiYi Cheng,Xuqi Peng,Li He et al.
WeiYi Cheng et al.
Arsenic trioxide (As2O3) has long been utilized in traditional Chinese medicine due to its therapeutic properties. While it exhibits potent anticancer activity, its clinical application is hindered by systemic toxicity and limited tissue sp...
Shikonin-Cu(II) Supramolecular Polymers Exhibit Antitumor Activity via Necrosis and Cuproptosis [0.03%]
茜草素-铜(II)超分子聚合物通过坏死和铜蛋白酶途径表现出抗肿瘤活性
Hongyang Zhang,Rui-Hong Gong,Yu Shan Lin et al.
Hongyang Zhang et al.
Supramolecular polymers driven by the metal-ligand coordination possess reversible bonds, making them promising candidates for integrating the therapeutic functions of metal ions and small-molecule drugs, and subsequently releasing these co...
Synchronously Delivering Melittin and Evoking Ferroptosis via Tumor Microenvironment-Triggered Self-Destructive Metal-Organic Frameworks to Boost Cancer Immunotherapy [0.03%]
通过肿瘤微环境触发的自毁金属有机框架同步递送蜂毒肽并诱发铁死亡以增强癌症免疫治疗
Dongsheng Zhang,Tingting Wang,Xun Zhang et al.
Dongsheng Zhang et al.
The primary goal of treating malignant tumors is to efficiently eliminate the primary tumor and prevent metastasis and recurrence. Unfortunately, the immunosuppressive tumor microenvironment (TME) is a significant obstacle to effective onco...
Manuel Pires-Santos,Mariana Carreira,Bruno P Morais et al.
Manuel Pires-Santos et al.
More recently, single-cell encapsulation emerged as a promising field in biomedicine due to its potential applications, in cell analysis and therapy. Traditional techniques involve embedding cells in crosslinked polymers to create continuou...
Immunoregulatory Neuro-Vascularized Osseointegration Driven by Different Nano-Morphological CaTiO3 Bioactive Coatings on Porous Titanium Alloy Scaffolds [0.03%]
具有不同纳米形态的CaTiO3生物活性涂层对多孔钛合金支架免疫调节神经-血管骨整合的影响
Dongmei Yu,Zhen Tang,Shusen Bao et al.
Dongmei Yu et al.
Up to now, how to implement the optimal regenerative repair of large load-bearing bone defects using artificial bone prosthesis remains to be an enormous challenge in clinical practice. Titanium-based alloys, especially Ti6Al4V, are applied...