Smart Theranostic Nanogels with Swelling-Driven Contrast for Multimodal Imaging, Sensing, and Photothermal Breast Cancer Ablation [0.03%]
一种用于多模影像、检测和光热乳腺癌消融的智能治疗纳米凝胶
Alice Sciortino,Maurizio Marrale,Cesare Gagliardo et al.
Alice Sciortino et al.
Integrating multimodal imaging and therapeutic functions into a single, stimuli-responsive nanoplatform for minimally invasive cancer therapy remains a major obstacle for theranostic nanomedicines. Most existing nanomedicines fail to sense ...
Dual-Nanocomplex Delivery of Neoantigen Vaccines and Doxorubicin for Synergistic Chemo-Immunotherapy against Colorectal Cancer [0.03%]
双纳米复方递送新抗原疫苗和多柔比星联合治疗结直肠癌
Weijian Zhao,Khattak Sameena Noor,Siyu Sun et al.
Weijian Zhao et al.
Colorectal cancer (CRC) is still an important global health challenge, with limited treatment efficacy. Neoantigen-based cancer vaccines offer tumor-specific immune activation but are limited by poor immunogenicity and rapid degradation, wh...
NIR-Triggered Janus Nanofiber Dressing with Synergistic Photodynamic Antibacterial Action and Sustained Oxygen Release for Accelerated Healing of Infected Wounds [0.03%]
用于感染伤口快速愈合的近红外触发Janus纳米纤维敷料，具有协同光动力抗菌作用和持续氧释放功能
Xiaoyong Huang,Bo Tian,Zhaojie Sun et al.
Xiaoyong Huang et al.
Impaired wound healing poses life-threatening risks due to uncontrolled multidrug-resistant bacterial infections. Although photodynamic therapy (PDT) represents a promising non-antibiotic strategy to combat antibiotic-resistant pathogens, i...
A Microphysiological Interface of Skeletal Myobundles and Inflamed Adipose Tissue for Recapitulating Muscle Dysfunction in an Obese Microenvironment [0.03%]
一种微生理界面，用于再现肥胖微环境中肌肉功能障碍的小骨骼肌索和发炎的脂肪组织
Seunggyu Kim,Tianxin Cao,Zhengpeng Wan et al.
Seunggyu Kim et al.
Systemic inflammation associated with obesity impairs skeletal muscle function through paracrine signaling from intermuscular adipose tissue-adipose depots situated between adjacent skeletal muscle groups-as well as from visceral adipose ti...
Fibrin-Targeting Metal-Organic Framework Nanoagent for NIR-Triggered Photothermal Thrombus Ablation [0.03%]
一种针对纤维蛋白的金属有机框架纳米剂用于近红外触发的光热血栓消融
Yu-Liang Chen,Ming-Hsin Liu,Ming-Feng Hsieh et al.
Yu-Liang Chen et al.
Thrombosis remains a leading cause of mortality worldwide; however, current thrombolytic therapies suffer from limited thrombus targeting, poor penetration, and systemic side effects. To address these challenges, a fibrin-targeting photothe...
Autonomous Soft Nanorobots for Active Targeting and Therapy of Triple-Negative Breast Cancer [0.03%]
用于三阴乳腺癌主动靶向及治疗的自主软纳米机器人
Wei Lu,Jiaxin Rui,Guangshu Zhou et al.
Wei Lu et al.
The extensive connective tissue proliferation and dense extracellular matrix (ECM) in triple-negative breast cancer (TNBC) form abnormal physical barriers that impede the penetration of nanomedicines and hinder therapeutic efficacy. Herein,...
Oxygen-Vacancy-Engineered Self-Regenerative Nanozymes in Dual-Signal-Responsive Dynamic Hydrogels: A Closed-Loop Therapeutic Strategy for Diabetic Wound Microenvironment Remodeling [0.03%]
用于双信号响应动态水凝胶的氧空位工程自再生纳米酶：一种闭环治疗策略，可重塑糖尿病伤口微环境
Xianchun Fu,Jing Wang,Han Zhang et al.
Xianchun Fu et al.
Diabetic wounds are trapped in a self-perpetuating pathological triad of hypoxia, infection, and oxidative stressdisrupting physiological wound healing and causing recalcitrant nonhealing ulcerswhile conventional therapies, limited by stati...
Localized Delivery of Anti-CD40/PD-1 Immunotherapy via a Polymeric Implant is Efficacious, Remodels the Tumor Immune Microenvironment and Improves Safety in a PDAC Mouse Model [0.03%]
通过聚合物植入局部递送抗CD40 / PD-1免疫疗法可有效治疗胰腺癌，重塑肿瘤免疫微环境并提高安全性
Elahe Minaei,Samantha J Wade,Chelsea Penney et al.
Elahe Minaei et al.
Pancreatic ductal adenocarcinoma (PDAC) remains largely unresponsive to immune checkpoint blockade due to its immunosuppressive tumor microenvironment and the systemic toxicity associated with combination immunotherapies. Here, this work re...
Modulating Bioactive Moieties on Self-Assembled Poly-Curcumin Nanoparticles via Electrochemical Tuning to Attenuate Inflammation in Sepsis [0.03%]
电化学调节自组装聚姜黄素纳米颗粒的生物活性基团以减轻脓毒症炎症
Chin-Jung Lin,Yu-Fen Huang,Chih-Ching Huang
Chin-Jung Lin
Sepsis is a life-threatening syndrome driven by dysregulated inflammation that leads to tissue injury, multi-organ failure, and high mortality, despite advances in supportive care. Here, a nanotherapeutic approach is reported using self-ass...
Lu Wang,Dongtao Zhou,Chao Teng et al.
Lu Wang et al.
Early diagnosis is essential for managing diseases and improving patient outcomes. Traditional diagnostic biomarkers are often limited by inadequate sensitivity and specificity, vulnerability to external influences, and difficulties in earl...