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Structure-Function Correlation of Clinically Inspired Lipid Nanoparticles for Lung and Spleen Targeted mRNA Delivery

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Lipid nanoparticles (LNPs) have emerged as a transformative platform for mRNA delivery. However, challenges such as low endosomal escape efficiency remain key barriers in the field. Herein, we systematically investigate the clinically approved COVID-19 vaccine... ...