Building barriers [0.03%]
筑墙之战
Kursad Turksen
Kursad Turksen
Formation of tissue barriers starts in early development where it is critical for normal cell fate selection, differentiation and organogenesis. Barrier maintenance is critical to the ongoing function of organs during adulthood and aging. D...
Pratap Karki,Konstantin G Birukov
Pratap Karki
Lipid mediators play a critical role in the development and resolution of vascular endothelial barrier dysfunction caused by various pathologic interventions. The accumulation of excess lipids directly impairs endothelial cell (EC) barrier ...
Phosphorylation of tight junction transmembrane proteins: Many sites, much to do [0.03%]
紧密连接跨膜蛋白的磷酸化：多个位点，多种功能
Christina M Van Itallie,James M Anderson
Christina M Van Itallie
Phosphorylation is a dynamic post-translational modification that can alter protein structure, localization, protein-protein interactions and stability. All of the identified tight junction transmembrane proteins can be multiply phosphoryla...
Intestinal barrier and gut microbiota: Shaping our immune responses throughout life [0.03%]
肠道屏障与肠道微生物群：一生中塑造我们的免疫反应
Tatiana Takiishi,Camila Ideli Morales Fenero,Niels Olsen Saraiva Câmara
Tatiana Takiishi
The gastrointestinal (GI) tract is considered the largest immunological organ in the body having a central role in regulating immune homeostasis. Contrary to earlier belief, the intestinal epithelial barrier is not a static physical barrier...
Conor Delaney,Matthew Campbell
Conor Delaney
The blood brain barrier is a necessity for cerebral homeostasis and response to environmental insult, thus loss in functionality with age creates opportunities for disease to arise in the aged brain. Understanding how the barrier is develop...
Airway epithelial barrier dysfunction in the pathogenesis and prognosis of respiratory tract diseases in childhood and adulthood [0.03%]
气道上皮屏障功能障碍在儿童和成人呼吸道疾病发病机制和预后中的作用
Hasan Yuksel,Ahmet Turkeli
Hasan Yuksel
The lungs are in direct contact with the environment through the tubular structure that constitutes the airway. Starting from the nasal orifice, the airway is exposed to foreign particles including infectious agents, allergens, and other su...
Intestinal surfactant permeation enhancers and their interaction with enterocyte cell membranes in a mucosal explant system [0.03%]
肠表面活性剂渗透增强剂及其与黏膜外植体系统中肠上皮细胞膜的相互作用
E Michael Danielsen,Gert H Hansen
E Michael Danielsen
Intestinal permeation enhancers (PEs) are agents aimed to improve oral delivery of therapeutic drugs with poor bioavailability. The main permeability barrier for oral delivery is the intestinal epithelium, and PEs act to increase the parace...
Amanda I Baumholtz,Indra R Gupta,Aimee K Ryan
Amanda I Baumholtz
The claudin family of tetraspan transmembrane proteins is essential for tight junction formation and regulation of paracellular transport between epithelial cells. Claudins also play a role in apical-basal cell polarity, cell adhesion and l...
Animal models for studying epithelial barriers in neonatal necrotizing enterocolitis, inflammatory bowel disease and colorectal cancer [0.03%]
动物模型在研究新生儿坏死性小肠结肠炎、炎症性肠病和结直肠癌上皮屏障中的应用
Tiaosi Xing,Rolando Camacho Salazar,Yan-Hua Chen
Tiaosi Xing
The intestinal epithelial cells line the luminal surface of the entire gastrointestinal tract which is crucial for the absorption of nutrients and prevention of pathogens entering from the external environment. The epithelial barrier plays ...
Natalya A Gloushankova,Svetlana N Rubtsova,Irina Y Zhitnyak
Natalya A Gloushankova
Adherens junctions (AJs) are molecular complexes that mediate cell-cell adhesive interactions and play pivotal roles in maintenance of tissue organization in adult organisms and at various stages of development. AJs consist of cadherin adhe...