An agonist of the cannabinoid-sensing G-protein coupled receptor 55 promotes wound healing and protects against UVB-induced keratinocyte damage [0.03%]
大麻素感应G蛋白偶联受体GPR55激动剂促进伤口愈合及抵抗UVB诱导的角质细胞损伤
Pimngeon Chatkul,Apiwan Arinno,Lapasrada Panpoca et al.
Pimngeon Chatkul et al.
The use of cannabinoid has been implicated in the treatment of various skin disorders with obscure mechanism of action. This study aimed to investigate the physiological roles of GPR55 in regenerating skin wounds and protecting keratinocyte...
Irisin-treated microbiota restore blood-testis barrier integrity and spermatogenesis in chronically stressed rats [0.03%]
Irisin治疗的微生物群可修复慢性压力大鼠的血-睾屏障完整性和生精功能
Itishree Dubey,Manisha Yadav,Sapana Kushwaha
Itishree Dubey
Chronic psychological stress impairs male fertility by disrupting spermatogenesis and the blood-testis barrier (BTB), which is essential for testicular function. Irisin, a myokine/adipokine involved in metabolic regulation, protects against...
Modeling tonsil organoids for studying mucosal immune responses to SARS-CoV-2 vaccination [0.03%]
用于研究SARS-CoV-2疫苗诱导的黏膜免疫反应的腭扁桃体类器官模型
Yang Gao,Wan Wang,Ying-Ying Wang et al.
Yang Gao et al.
A key bottleneck in preclinical vaccine research is the lack of a human in vitro system that faithfully models the germinal center (GC) reactions, a critical process for generating protective antibodies. This gap hinders the accurate assess...
Claudins as signaling hubs of fibrosis, autophagy, and metabolism [0.03%]
Claudin信号转导中心在纤维化、自噬和代谢中的作用
Haruna Fukunaga,Yuki Niwa,Masuo Kondoh
Haruna Fukunaga
Claudins were identified in 1998 as structural and functional components of tight junction (TJ) seals between adjacent epithelial cells. Since their identification, pharmaceutical research has mainly focused on junctional claudins. For exam...
Intestine organotypic culture recapitulates human embryonic villus morphogenesis at week 8 [0.03%]
小肠器官型培养再现了人胚第8周绒毛发生形态生成
Melis Asal,Nanne J Paauw,Maria Thon et al.
Melis Asal et al.
The human small intestine depends on villi to generate the large absorptive surface area required for nutrient uptake and barrier integrity. Existing human in vitro models fail to reproduce early villus morphogenesis, as they lack developme...
Erlotinib impairs epidermal tight junction and barrier integrity by inhibiting EGFR and Src and affects maturation of cell-cell junctions in human and mouse keratinocytes [0.03%]
厄洛替尼通过抑制EGFR和Src损害表皮紧密连接及屏障完整性并影响人体和小鼠角质形成细胞间连接的成熟
Keisuke Imafuku,Alexander Garcia-Ponce,Jens Waschke
Keisuke Imafuku
Erlotinib, an epidermal growth factor receptor (EGFR) inhibitor, is widely used in cancer therapy but frequently causes cutaneous adverse effects that suggest impairment of the epidermal barrier. To better understand the underlying mechanis...
A Dsg3-specific pemphigus autoantibody induces formation of immature desmosomes associated with impaired adhesion [0.03%]
Dsg3特异性疱疹autoantibody诱导形成与粘附损伤相关的不成熟桥粒
Julia Huber,Michael Fuchs,Jens Waschke et al.
Julia Huber et al.
Pemphigus is a severe blistering autoimmune disease in which autoantibodies against the desmosomal cadherins Dsg1 and Dsg3 cause loss of desmosome adhesion. It is hypothesized that this loss of adhesion results from a combination of direct ...
Blood-brain barrier permeability in diffuse large B-Cell lymphoma: associations with established risk factors for CNS relapse [0.03%]
弥漫性大B细胞淋巴瘤中的血脑屏障通透性与中枢神经系统复发已知危险因素的关系研究
Martine Prütz Nørskov,Elisabeth Præstekjær Cramer,Ulrich Lindberg et al.
Martine Prütz Nørskov et al.
Central nervous system (CNS) relapse is a serious complication of diffuse large B-Cell lymphoma (DLBCL), often associated with poor clinical outcomes. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) enables detection of subtl...
Developmental maturation of intestinal junctional complexes in preterm infants [0.03%]
早产儿肠道连接复合物的发育成熟过程
Catherine Kollmann,Carolin Niklas,Karen Ernestus et al.
Catherine Kollmann et al.
Preterm infants are prone to gastrointestinal complications such as infectious diseases and necrotizing enterocolitis, which are associated with intestinal inflammation and increased intestinal permeability. Intestinal epithelial barrier (I...
Inflammation and epidermal barrier integrity, decline, and restoration: It's time to rouse the "guardians at the gate" [0.03%]
炎症与表皮屏障的完整性和衰退及修复：是时候唤醒“守门人”了
Michael L Samulevich,Liam E Carman,Brian J Aneskievich
Michael L Samulevich
Epidermal barrier (EB) function is too often reduced to the role of a passive, inanimate upper strata of dead corneocytes surrounded by extruded lipids. However, this summary fails to appreciate the lower strata keratinocytes (KCs) which se...