Lipid depletion enables permeation of Staphylococcus aureus bacteria through human stratum corneum [0.03%]
脂质耗尽可使金黄色葡萄球菌通过人体角质层
Zachary W Lipsky,Cláudia N H Marques,Guy K German
Zachary W Lipsky
Atopic dermatitis (AD) is a chronic inflammatory disease that affects approximately 2-5% of adults worldwide. The pathogenesis of AD continues to be a well-debated point of conjecture, with numerous hypotheses having been proposed. AD condi...
Optimization of an oral mucosa in vitro model based on cell line TR146 [0.03%]
基于TR146细胞系的体外口腔黏膜模型优化研究
Grace C Lin,Tamara Leitgeb,Alexandra Vladetic et al.
Grace C Lin et al.
During the last years, the popularity of saliva has been increasing for its applicability as a diagnostic fluid. Blood biomarker molecules have to cross the blood-saliva barrier (BSB) in order to appear in saliva. The BSB consists of all or...
HIV Tat-mediated induction of autophagy regulates the disruption of ZO-1 in brain endothelial cells [0.03%]
HIV蛋白Tat诱导的自噬调节脑内皮细胞ZO-1崩解
Ke Liao,Fang Niu,Guoku Hu et al.
Ke Liao et al.
The blood-brain barrier (BBB) is a tight barrier that is critical for preventing the entry of pathogens and small molecules into the brain. HIV protein Tat (Tat) is known to disrupt the tight junctions of the BBB. Autophagy is an intracellu...
Short-term tissue permeability actions of dextran sulfate sodium studied in a colon organ culture system [0.03%]
葡聚糖硫酸钠短期渗透作用的结肠器官培养研究
Elisabeth M Danielsen,Alba De Haro Hernando,Mohammad Yassin et al.
Elisabeth M Danielsen et al.
Dextran sulfate sodium (DSS)-induced colitis is the most commonly used animal model for inflammatory bowel diseases. However, the precise molecular action of DSS, in particular its initial effect on the epithelial tissue permeability, is st...
Cholix protein domain I functions as a carrier element for efficient apical to basal epithelial transcytosis [0.03%]
cholix蛋白结构域I作为有效上皮细胞反向转运的载体元件
Alistair Taverner,Julia MacKay,Floriane Laurent et al.
Alistair Taverner et al.
Cholix (Chx) is expressed by the intestinal pathogen Vibrio cholerae as a single chain of 634 amino acids (~70.7 kDa protein) that folds into three distinct domains, with elements of the second and third domains being involved in accessing ...
The 1st international symposium on mucosal health in aquaculture - MHA2019 [0.03%]
第一届水产养殖黏膜健康国际研讨会(MHA2019)
Carlo C Lazado
Carlo C Lazado
The 1st International Symposium on Mucosal Health and Aquaculture (MHA2019) was held on 11-13 September 2019 in Oslo, Norway. This was the first platform of its kind that gathered people from academia, R&D institutes, and industry to discus...
Sophia K Theodossiou,Jett B Murray,Nathan R Schiele
Sophia K Theodossiou
Tendons connect muscles to bones to transfer the forces necessary for movement. Cell-cell junction proteins, cadherins and connexins, may play a role in tendon development and injury. In this review, we begin by highlighting current underst...
Epithelial barrier dysfunction and cell migration induction via JNK/cofilin/actin by angubindin-1 [0.03%]
Angubindin-1通过JNK/cofilin/肌动蛋白诱导上皮屏障功能障碍和细胞迁移
Takumi Konno,Takayuki Kohno,Shin Kikuchi et al.
Takumi Konno et al.
Angulin-1/LSR is a tricellular tight junction molecule, that plays an important role in maintaining the epithelial and endothelial barriers. The actin cytoskeleton at tricellular contacts also contributes to the maintenance of the epithelia...
Engineering drug delivery systems to overcome mucosal barriers for immunotherapy and vaccination [0.03%]
工程化药物递送系统以克服黏膜屏障在免疫治疗和疫苗接种中的应用
Jacob C McCright,Katharina Maisel
Jacob C McCright
Mucosal surfaces protect our bodies from pathogens and external irritants using a system of biological barriers. Overcoming these barriers is a significant drug delivery challenge, particularly for immunotherapies that aim to modulate the l...
Fadi E Pulous,Brian G Petrich
Fadi E Pulous
The endothelium physically separates blood from surrounding tissue and yet allows for the regulated passage of nutrients, waste, and leukocytes into and out of the circulation. Trans-endothelium flux occurs across endothelial cells (transce...