Short-term tissue permeability actions of dextran sulfate sodium studied in a colon organ culture system [0.03%]
葡聚糖硫酸钠短期渗透作用的结肠器官培养研究
Elisabeth M Danielsen,Alba De Haro Hernando,Mohammad Yassin et al.
Elisabeth M Danielsen et al.
Dextran sulfate sodium (DSS)-induced colitis is the most commonly used animal model for inflammatory bowel diseases. However, the precise molecular action of DSS, in particular its initial effect on the epithelial tissue permeability, is st...
Cholix protein domain I functions as a carrier element for efficient apical to basal epithelial transcytosis [0.03%]
cholix蛋白结构域I作为有效上皮细胞反向转运的载体元件
Alistair Taverner,Julia MacKay,Floriane Laurent et al.
Alistair Taverner et al.
Cholix (Chx) is expressed by the intestinal pathogen Vibrio cholerae as a single chain of 634 amino acids (~70.7 kDa protein) that folds into three distinct domains, with elements of the second and third domains being involved in accessing ...
The 1st international symposium on mucosal health in aquaculture - MHA2019 [0.03%]
第一届水产养殖黏膜健康国际研讨会(MHA2019)
Carlo C Lazado
Carlo C Lazado
The 1st International Symposium on Mucosal Health and Aquaculture (MHA2019) was held on 11-13 September 2019 in Oslo, Norway. This was the first platform of its kind that gathered people from academia, R&D institutes, and industry to discus...
Sophia K Theodossiou,Jett B Murray,Nathan R Schiele
Sophia K Theodossiou
Tendons connect muscles to bones to transfer the forces necessary for movement. Cell-cell junction proteins, cadherins and connexins, may play a role in tendon development and injury. In this review, we begin by highlighting current underst...
Epithelial barrier dysfunction and cell migration induction via JNK/cofilin/actin by angubindin-1 [0.03%]
Angubindin-1通过JNK/cofilin/肌动蛋白诱导上皮屏障功能障碍和细胞迁移
Takumi Konno,Takayuki Kohno,Shin Kikuchi et al.
Takumi Konno et al.
Angulin-1/LSR is a tricellular tight junction molecule, that plays an important role in maintaining the epithelial and endothelial barriers. The actin cytoskeleton at tricellular contacts also contributes to the maintenance of the epithelia...
Engineering drug delivery systems to overcome mucosal barriers for immunotherapy and vaccination [0.03%]
工程化药物递送系统以克服黏膜屏障在免疫治疗和疫苗接种中的应用
Jacob C McCright,Katharina Maisel
Jacob C McCright
Mucosal surfaces protect our bodies from pathogens and external irritants using a system of biological barriers. Overcoming these barriers is a significant drug delivery challenge, particularly for immunotherapies that aim to modulate the l...
Fadi E Pulous,Brian G Petrich
Fadi E Pulous
The endothelium physically separates blood from surrounding tissue and yet allows for the regulated passage of nutrients, waste, and leukocytes into and out of the circulation. Trans-endothelium flux occurs across endothelial cells (transce...
Mohammad A Uddin,Mohammad S Akhter,Sitanshu S Singh et al.
Mohammad A Uddin et al.
Growth Hormone-Releasing Hormone (GHRH) regulates the release of growth hormone from the anterior pituitary gland. GHRH also acts as a growth and inflammatory factor in a variety of experimental models in oncology. In the current study, we ...
The extracellular matrix of the blood-brain barrier: structural and functional roles in health, aging, and Alzheimer's disease [0.03%]
血脑屏障的细胞外基质：其在健康、衰老和阿尔茨海默病中的结构及功能作用
May J Reed,Mamatha Damodarasamy,William A Banks
May J Reed
There is increasing interest in defining the location, content, and role of extracellular matrix (ECM) components in brain structure and function during development, aging, injury, and neurodegeneration. Studies in vivo confirm brain ECM ha...
Differential gene expression and gene-set enrichment analysis in Caco-2 monolayers during a 30-day timeline with Dexamethasone exposure [0.03%]
地塞米松暴露下Caco-2单层细胞30天时间线上差异基因表达和基因集富集分析
J M Robinson,S Turkington,S A Abey et al.
J M Robinson et al.
Glucocorticoid hormones affect gene expression via activation of glucocorticoid receptor NR3C1, causing modulation of inflammation and autoimmune activation. The glucocorticoid Dexamethasone is an important pharmaceutical for the treatment ...