The blood-brain and gut-vascular barriers: from the perspective of claudins [0.03%]
从Claudin视角看血脑屏障和肠血管屏障
Anna Agata Scalise,Nikolaos Kakogiannos,Federica Zanardi et al.
Anna Agata Scalise et al.
In some organs, such as the brain, endothelial cells form a robust and highly selective blood-to-tissue barrier. However, in other organs, such as the intestine, endothelial cells provide less stringent permeability, to allow rapid exchange...
Anke C Ziegler,Markus H Gräler
Anke C Ziegler
Sphingosine 1-phosphate (S1P) is a multifaceted lipid signaling molecule that activates five specific G protein-coupled S1P receptors. Despite the fact that S1P is known as one of the strongest barrier-enhancing molecules for two decades, n...
Induction of the NEK family of kinases in the lungs of mice subjected to cecal ligation and puncture model of sepsis [0.03%]
内毒素诱导NEK家族激酶在脂多糖及脓毒症小鼠肺中的表达上调
Mohammad A Uddin,Mohammad S Akhter,Khadeja-Tul Kubra et al.
Mohammad A Uddin et al.
Endothelial barrier dysfunction (EBD) is the hallmark of Acute Respiratory Distress Syndrome (ARDS), a potentially lethal respiratory disorder associated with the COVID-19 - related deaths. Herein, we employed a cecal ligation and puncture ...
Asymmetric distribution of dynamin-2 and β-catenin relative to tight junction spikes in alveolar epithelial cells [0.03%]
肺泡上皮细胞中动力蛋白-2和β-连环蛋白在紧密连接突起的不对称分布
K Sabrina Lynn,Kristen F Easley,Francisco J Martinez et al.
K Sabrina Lynn et al.
Tight junctions between lung alveolar epithelial cells maintain an air-liquid barrier necessary for healthy lung function. Previously, we found that rearrangement of tight junctions from a linear, cortical orientation into perpendicular pro...
MRCK: a master regulator of tissue remodeling or another 'ROCK' in the epithelial block? [0.03%]
MRCK：上皮闭合中的“组织重塑主调节因子”还是又一个“ROCK”？
Ceniz Zihni
Ceniz Zihni
The epithelium forms a smart barrier to the external environment that can remodel whilst maintaining tissue integrity, a feature important for development, homeostasis, and function. Its dysregulation can lead to diseases ranging from cance...
Fruzsina R Walter,Ana R Santa-Maria,Mária Mészáros et al.
Fruzsina R Walter et al.
The negative surface charge of brain microvessel endothelial cells is derived from the special composition of their membrane lipids and the thick endothelial surface glycocalyx. They are important elements of the unique defense systems of t...
HDAC inhibitor, MS-275, increases vascular permeability by suppressing Robo4 expression in endothelial cells [0.03%]
组蛋白脱乙酰酶抑制剂MS-275通过抑制血管内皮细胞Robo4的表达增加血管通透性
Taito Kashio,Keisuke Shirakura,Mayumi Kinoshita et al.
Taito Kashio et al.
Roundabout guidance receptor 4 (Robo4) is an endothelial-specific membrane protein that suppresses pathological angiogenesis and vascular hyperpermeability by stabilizing endothelial cells. Robo4 suppresses severe systemic inflammation indu...
Kotaro Sugimoto,Hideki Chiba
Kotaro Sugimoto
Claudins (CLDNs) represent major transmembrane proteins of tight junctions and contribute to the barrier function. They also serve as anchors for several signaling proteins, but the underlying molecular basis has yet to be established. The ...
RNA-binding proteins and long noncoding RNAs in intestinal epithelial autophagy and barrier function [0.03%]
肠道上皮自噬和屏障功能中的rna结合蛋白和长链非编码rna
Lan Xiao,Jaladanki N Rao,Jian-Ying Wang
Lan Xiao
The intestinal autophagy and barrier function are crucial for maintaining the epithelium homeostasis and tightly regulated through well-controlled mechanisms. RNA-binding proteins (RBPs) and long noncoding RNAs (lncRNAs) modulate gene expre...
Pyk2 inhibitor prevents epithelial hyperpermeability induced by HMGB1 and inflammatory cytokines in Caco-2 cells [0.03%]
Pyk2抑制剂预防HMGB1和炎症细胞因子诱导的Caco-2细胞上皮屏障功能障碍
Takumi Konno,Takayuki Kohno,Maki Miyakawa et al.
Takumi Konno et al.
The non-receptor protein tyrosine kinase 2β (Pyk2) phosphorylated tricellular tight junction (tTJ) molecules angulin-1/LSR and tricellulin (TRIC) and the inhibitor PF-431396 (PF43) suppress angulin-1/LSR and TRIC recruitment to tTJs. The d...