HDAC inhibitor, MS-275, increases vascular permeability by suppressing Robo4 expression in endothelial cells
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Roundabout guidance receptor 4 (Robo4) is an endothelial-specific membrane protein that suppresses pathological angiogenesis and vascular hyperpermeability by stabilizing endothelial cells. Robo4 suppresses severe systemic inflammation induced by pathogens and... ...
