Spatial composition and turnover of the main molecules in the adult glomerular basement membrane [0.03%]
成人肾小球基底膜主要分子的时空组成和周转
David W Smith,Azin Azadi,Chang-Joon Lee et al.
David W Smith et al.
The glomerular basement membrane (GBM) is an important tissue structure in kidney function. It is the membrane through which filtrate and solutes must pass to reach the nephron tubules. This review focuses on the spatial location of the mai...
LSR antibody promotes apoptosis and disrupts epithelial barriers via signal pathways in endometrial cancer [0.03%]
LSR抗体通过信号途径促进子宫内膜癌细胞凋亡及破坏上皮屏障作用
Kimihito Saito,Takumi Konno,Takayuki Kohno et al.
Kimihito Saito et al.
Lipolysis-stimulated lipoprotein receptor (LSR), a lipid metabolism-related factor localized in tricellular tight junctions (tTJs), plays an important role in maintaining the epithelial barrier. LSR is highly expressed in well-differentiate...
Delay of endothelial cell senescence protects cerebral barrier against age-related dysfunction: role of senolytics and senomorphics [0.03%]
内皮细胞衰老的延迟保护脑屏障免于年龄相关功能障碍：衰老素和抗衰老药的作用
Jingyuan Ya,Rais Reskiawan A Kadir,Ulvi Bayraktutan
Jingyuan Ya
Accumulation of senescent cells in cerebrovasculature is thought to play an important role in age-related disruption of blood-brain barrier (BBB). Using an in vitro model of human BBB, composed of brain microvascular endothelial cells (BMEC...
Interplay between EGFR, E-cadherin, and PTP1B in epidermal homeostasis [0.03%]
EGFR、E-钙黏蛋白和PTP1B在表皮稳态中的相互作用
Tessa Arnaud,Fernando Rodrigues-Lima,Mireille Viguier et al.
Tessa Arnaud et al.
Maintaining epithelial homeostasis is crucial to allow embryo development but also the protective barrier which is ensured by the epidermis. This homeostasis is regulated through the expression of several molecules among which EGFR and E-ca...
Urothelium removal does not impact mucosal activity in response to muscarinic or adrenergic receptor stimulation [0.03%]
去除上皮细胞后黏膜对胆碱能或肾上腺素能受体刺激的反应不受影响
Christian Moro,Charlotte Phelps
Christian Moro
The inner lining of the urinary bladder (urothelium and lamina propria, or bladder mucosa) has an important role as a tissue barrier between stored urine and the underlying smooth muscle, as well as in the modulation and regulation of bladd...
Mucosal p-STAT1/3 correlates with histologic disease activity in Crohn's disease and is responsive to filgotinib [0.03%]
黏膜p-STAT1/3与克罗恩病的组织学疾病活动度相关，并对filgotinib有反应
Walter Reinisch,Adrian Serone,Xavier Hébuterne et al.
Walter Reinisch et al.
The validity and relevance of histologic disease activity in Crohn's disease (CD) is unclear, owing to disconnects with endoscopic pathology. Here, we explore relationships between endoscopic, histologic, and molecular activity. This post h...
Clinical Trial
Tissue barriers. 2023 Apr 3;11(2):2088961. DOI:10.1080/21688370.2022.2088961 2023
Roles of the ACE/Ang II/AT1R pathway, cytokine release, and alteration of tight junctions in COVID-19 pathogenesis [0.03%]
ACE／AngⅡ／AT1R途径、细胞因子释放和紧密连接改变在新冠肺炎发病机制中的作用
Laith Ashour
Laith Ashour
This paper shows how SARS-CoV-2 alters tight junctions (TJs) in human organs. The effect of SARS-CoV-2 on the ACE/Ang II/AT1R pathway and immune cells culminates in the release of numerous pro-inflammatory mediators, leading to the presence...
Kasey D Boger,Ana E Sheridan,Amanda L Ziegler et al.
Kasey D Boger et al.
The intestinal epithelial barrier is susceptible to injury from insults, such as ischemia or infectious disease. The epithelium's ability to repair wounded regions is critical to maintaining barrier integrity. Mechanisms of intestinal epith...
Christina Kingsley,Antonis Kourtidis
Christina Kingsley
The oral cavity is directly exposed to a variety of environmental stimuli and contains a diverse microbiome that continuously interacts with the oral epithelium. Therefore, establishment and maintenance of the barrier function of the oral m...
Aekkacha Moonwiriyakit,Nutthapoom Pathomthongtaweechai,Peter R Steinhagen et al.
Aekkacha Moonwiriyakit et al.
Intestinal epithelium functions as a tissue barrier to prevent interaction between the internal compartment and the external milieu. Intestinal barrier function also determines epithelial polarity for the absorption of nutrients and the sec...