Immortal genome assumption significantly underestimates replication and death rates of Mycobacterium tuberculosis in mice and monkeys [0.03%]
假定结核分枝杆菌基因组不会死亡显著低估了其在小鼠和猴子体内的复制和消亡速率
Allan D Friesen,Vitaly V Ganusov
Allan D Friesen
Immune correlates of protection against infection with Mycobacterium tuberculosis (Mtb) or against tuberculosis (TB) remain poorly defined. The ratio of colony-forming units (CFUs) to chromosomal equivalents (CEQs), [Formula: see text], rec...
Genome-based re-evaluation of the ECA75F sequence and development of a dual-probe real-time PCR assay for differentiating Shigella species and enteroinvasive Escherichia coli [0.03%]
基于基因组的ECA75F序列重新评估及用于区分志贺菌和侵袭性大肠杆菌的双探针实时PCR检测方法开发
Junko Isobe,Tetsuya Harada,Emi Maenishi et al.
Junko Isobe et al.
Shigella species and enteroinvasive Escherichia coli (EIEC) have highly similar biochemical, serological, and pathogenic profiles, making their differentiation challenging. Although the 25-base sequence ECA75F within the 16S rRNA gene has b...
Public health data collected by PulseNet support a role for spv genes in cases of bacteremia caused by Salmonella Typhimurium and I 4,[5],12:i: [0.03%]
PulseNet收集的公共卫生数据支持spv基因在Salmonella Typhimurium和I 4,[5],12:i:-菌血症病例中发挥作用
Aimee R P Tierney,Patricia I Fields,Zainab Salah et al.
Aimee R P Tierney et al.
Nontyphoidal Salmonella enterica (NTS) infections in humans typically present as self-limiting gastroenteritis, but a small percentage progress to extraintestinal illness, including bacteremia. The spvRABCD (Salmonella plasmid virulence) lo...
From screening to treatment: in vitro and in vivo efficacy of phage-meropenem combination against highly virulent Carbapenem-resistant Acinetobacter baumannii [0.03%]
从筛查到治疗：噬菌体-美罗培南联合疗法对高致病性碳青霉烯类耐药鲍曼不动杆菌的体内外疗效评估
Lan Liao,Shanchen Yang,Gang Luo et al.
Lan Liao et al.
Carbapenem-resistant Acinetobacter baumannii (CRAB) is a hospital-acquired pathogen of significant clinical importance. Given the slow progress in antibiotic development, phages have emerged as a novel therapeutic strategy against CRAB infe...
Targeting the stringent response alters gene expression and extracellular vesicle RNA in Staphylococcus aureus [0.03%]
靶向严格应答改变金黄色葡萄球菌的基因表达和细胞外囊泡RNA
Sarah C Mansour,Samuel J T Wardell,Arjun S Baghela et al.
Sarah C Mansour et al.
Staphylococcus aureus relies on the (p)ppGpp-mediated stringent response to adapt to nutrient limitation and other environmental stress, with important consequences for metabolism, antibiotic tolerance, and virulence. In this study, we iden...
Spatial ecology meets quality control: a GIS-integrated strategy for visualizing and managing microbial contamination in sterile pharmaceutical cleanrooms [0.03%]
空间生态学与质量控制的结合：一种集成GIS的策略，用于可视化和管理无菌药品洁净室中的微生物污染
Jiaji Wang,Pan Jiang,Junhui Yan et al.
Jiaji Wang et al.
To enhance contamination source identification in sterile drug manufacturing, this study innovatively developed an integrated strategy combining geographic information system (GIS) spatial visualization with microbial contamination control....
Ecological plasticity of Halanaerobium microorganisms across terrestrial saline to hypersaline subsurface environments [0.03%]
盐土栖芽胞菌属微生物在地下咸水到超咸水环境中的生态可塑性
Yu He,Xinhang Wang,Shuyi Li et al.
Yu He et al.
Members of the genus Halanaerobium are widely distributed in hypersaline environments, including oil and gas reservoirs, and saline lake sediment. However, a comprehensive understanding of their physiological traits, metabolic capacities, a...
Revised complete genome sequences of Limosilactobacillus reuteri DSM 20016T and ATCC PTA-6475 and confirmation of an intragenic macrosatellite in adhesin gene cmbA [0.03%]
副干链球菌DSM 20016T和ATCC PTA-6475的修订完成基因组序列以及粘附素基因cmbA中的内含大型卫星重复序列的确认
Mohamed R Kady,Robert A Britton
Mohamed R Kady
Cell and mucus binding protein A (CmbA) is a cell-wall-anchored adhesin common to human isolates of Limosilactobacillus reuteri, which governs mucosal adhesion in vitro. Recent attempts to sequence cmbA in different L. reuteri strains revea...
Commercial washing and storage over shelf life impact bacterial communities more than the fungal communities on baby spinach [0.03%]
商业清洗及货架期内的储存对婴儿菠菜细菌群落的影响大于真菌群落的影响
Tamara Walsky,Sriya Sunil,Samantha Bolten et al.
Tamara Walsky et al.
Many types of minimally processed fresh produce, including baby spinach, are sensitive to microbial spoilage and other defects that influence quality and consumer acceptance. However, there is limited understanding of how various growing, p...
Magnesium enhances the expression of arthroconidia-related genes in Trichosporon asahii [0.03%]
镁增强Asahii小孢子菌关节孢子相关基因的表达
Keita Aoki,Minenosuke Matsutani,Moriya Ohkuma et al.
Keita Aoki et al.
Trichosporon asahii is a pleomorphic basidiomycetous yeast that causes deep-seated mycoses in immunocompromised individuals. T. asahii exhibits three morphological types: hyphae, yeasts, and arthroconidia. Hyphal formation is related to vir...