Morphotype-specific susceptibility to Neosartorya (Aspergillus) fischeri antifungal protein 2 is associated with an anabolic transcriptional signature in Candida [0.03%]
新型棒束气抱霉抗真菌蛋白2型特异性敏感性与酒药酵母菌合成代谢转录信号有关
Richárd Merber,Krisztián Laczi,Gábor Bende et al.
Richárd Merber et al.
The emergence of drug-resistant Candida species has created a demand for global antifungal strategies that extend beyond classical growth inhibition to target unknown vulnerabilities of fungal pathogens. In this study, we demonstrated that ...
High abundance of Stenotrophomonas maltophilia in slaty-backed gull breeding in Northern Japan [0.03%]
日本北海道繁殖的黑背鸥中产碱普罗威登氏菌广泛存在
Mako Kawai,Ren Fujita,Riko Ohshima et al.
Mako Kawai et al.
Stenotrophomonas maltophilia is a gram-negative bacillus that is widely distributed in the natural environment and is known to cause opportunistic infections. While it has been isolated from diverse wildlife, the relationship between migrat...
Rhein reduces conjugation of IncFII-type plasmids in Escherichia coli and mitigates the spread of antibiotic resistance genes [0.03%]
Rhien可减少大肠杆菌中IncFII型质粒的接合并减轻抗生素抗性基因的传播
Nannan Wang,Haitao Ma,Hanyan Cheng et al.
Nannan Wang et al.
Antibiotic resistance genes (ARGs) can be rapidly disseminated via bacterial conjugation, resulting in a substantial decline in the clinical efficacy of antibiotics. Novel therapeutic strategies independent of conventional antimicrobials ar...
Phenotypic discordance in rifampicin resistance detection among Mycobacterium tuberculosis isolates from China: insights from whole-genome sequencing and a structured literature review [0.03%]
耐利福平鼠疫耶尔森菌表型差异的全基因组测序及文献分析研究
Ya-Li Chen,Cui-Ping Guan,Yun-Feng Deng et al.
Ya-Li Chen et al.
Phenotypic drug susceptibility testing (pDST) for rifampicin (RIF) resistance in Mycobacterium tuberculosis (MTB) can yield discordant results between solid and liquid culture methods, complicating accurate detection of drug-resistant tuber...
Identification of protein secretion systems and type III effectors in wood-associated bacteria of the genus Xylophilus [0.03%]
分泌蛋白系统和III型效应因子的鉴定及其在附木菌属细菌中的分布
Zoe Roux,Naama Wagner,Laurent Brottier et al.
Zoe Roux et al.
To gain insights into the biology of bacteria of the genus Xylophilus, including the grapevine pathogen Xylophilus ampelinus, we scrutinized all available genome sequences of the genus for the presence of type III secretion and flagellar sy...
Intraspecific diversity of Staphylococcus aureus populations isolated from cystic fibrosis respiratory infections [0.03%]
来自囊性纤维化呼吸感染的金黄色葡萄球菌种内多样性
Ashley M Alexander,Hui Qi Loo,Lauren Askew et al.
Ashley M Alexander et al.
Long-term associations within an individual host allow bacterial populations to diversify over time, sometimes resulting in the coexistence of multiple species or variants of the same species. Traditional methods for identifying infective a...
Challenges in ITS-based identification of Cunninghamella bertholletiae and Rhizopus microsporus due to intragenomic ITS sequence heterogeneity [0.03%]
ITS序列异质性导致的粗球孢子菌和小型裸囊梗菌鉴定难题
Wan-Lin Wu,Pui-Ching Choi,Hsuan-Chen Wang et al.
Wan-Lin Wu et al.
Cunninghamella bertholletiae and Rhizopus microsporus are clinically important Mucorales that frequently exhibit mixed peaks in chromatograms from conventional Sanger sequencing of the internal transcribed spacer (ITS) region. Intragenomic ...
Risk of acute kidney injury in patients on concomitant vancomycin and piperacillin-tazobactam compared to vancomycin and other beta-lactam agents: a large multicenter retrospective cohort study from China [0.03%]
万古霉素联合哌拉西林他唑巴唑与万古霉素联合其他β-内酰胺类药物治疗患者急性肾损伤的风险：一项大型多中心回顾性队列研究
Kunming Pan,Xingyun Hou,Jie Li et al.
Kunming Pan et al.
Acute kidney injury (AKI) associated with vancomycin (VAN) plus piperacillin-tazobactam (PTZ) remains controversial, with over two-thirds of current evidence originating from US populations. This study evaluated AKI risk with VAN/PTZ vs VAN...
Systematic establishment of approaches to the detection of equine macrophage polarization and their application in pathogenic infection [0.03%]
系统建立马巨噬细胞极化检测方法并应用于病原感染研究
Kewei Chen,Cheng Du,Yingyi Duan et al.
Kewei Chen et al.
Macrophage phenotypic adaptation critically regulates inflammatory balance during infection; however, progress in equine immunology has been limited by a lack of specific tools for standardized identification. To address this gap, we establ...
Ribosome hibernation in zinc-starved Mycobacterium abscessus confers amikacin tolerance [0.03%]
锌缺乏条件下鸟分枝杆菌迟缓亚种的核糖体休眠赋予阿米卡星抗性
Ryan Z Treen,Austin J Fox,Yunlong Li et al.
Ryan Z Treen et al.
Intrinsic and acquired antibiotic resistance in Mycobacterium abscessus present unique challenges in treatment of its infections, which are rapidly emerging as a significant public health threat. The majority of clinically relevant antibiot...