Léo Laoubi,Elisa Gobbini,Pierre Duplouye et al.
Léo Laoubi et al.
Dendritic cells (DCs) are central players in the immune system, serving as a bridge between innate and adaptive immunity. Their unique abilities to capture, process, migrate, and present tumor-associated antigens to T cells make them essent...
Inhibiting SLAMF8 modulates tumor-associated macrophages and restores CD8+ T cell-mediated antitumor immunity in colorectal cancer [0.03%]
SLAMF8抑制调控肿瘤相关巨噬细胞并恢复结直肠癌中CD8+T细胞介导的抗肿瘤免疫
Xingzhi Han,Xueying Bai,Ning Wang et al.
Xingzhi Han et al.
SLAMF8 is predominantly expressed in macrophages and plays an important role in autoimmune diseases and inflammation. Our previous studies have focused on SLAMF8, however, the potential of SLAMF8 as an immunotherapeutic target and its role ...
Intratumoral regulatory T cells are associated with treatment response to neoadjuvant chemotherapy and prognosis in gastroesophageal adenocarcinoma [0.03%]
肿瘤内调节性T细胞与胃食管腺癌新辅助化疗反应和预后的关联研究
Franziska Baenke,Antonia Stammberger,Ulrich Sommer et al.
Franziska Baenke et al.
Gastroesophageal junction (GEJ) adenocarcinoma is an increasingly common cancer with complex biology and poor prognosis. The treatment strategy for locally advanced tumors involves multimodal treatment with perioperative chemotherapy. Howev...
Membrane IL-18 identifies a human macrophage subset with distinct proteomic and functional traits [0.03%]
膜IL-18识别具有不同蛋白质和功能特征的人类巨噬细胞亚群
Chiara Vitale,Andrea Petretto,Katia Cortese et al.
Chiara Vitale et al.
This study contributes to the characterization of human macrophages in normal and pathological conditions such as cancer. We characterized a macrophage population expressing membrane-associated IL-18 (mIL-18) that shows peculiar proteomic, ...
Simultaneous secretion of a PD-L1 x 4-1BB bispecific antibody improves antileukemic efficacy of STAb-T cells secreting a CD19-specific T-cell engager [0.03%]
同时分泌PD-L1×4-1BB双特异性抗体可提高分泌CD19特异性T细胞衔接剂的STAb-T细胞的抗白血病疗效
Marina Gómez-Rosel,Laura Rubio-Pérez,Ivana Zagorac et al.
Marina Gómez-Rosel et al.
Adoptive therapy with CAR-T cells and systemic administration of bispecific T-cell engagers (TCE) have achieved unprecedented success in the treatment of relapsed/refractory (R/R) B-cell malignancies. However, high relapse rates remain a ma...
Tumor-infiltrating lymphocytes-derived CD8+ clonotypes infiltrate the tumor tissue and mediate tumor regression in glioblastoma [0.03%]
胶质母细胞瘤中肿瘤浸润性淋巴细胞来源的CD8+克隆型侵入肿瘤组织并介导肿瘤消退
Lucas C M Arruda,Julia Karbach,Dragan Kiselicki et al.
Lucas C M Arruda et al.
Adoptive cell therapy with tumor-infiltrating lymphocytes (TILs) has demonstrated consistent clinical efficacy in treating advanced melanoma and other "hot" tumors. However, it has shown limited success in "cold" tumors like glioblastoma. W...
Selective serotonin reuptake inhibitors enhance cancer immunosurveillance by pleiotropic mechanisms [0.03%]
五羟色胺回收抑制剂通过多种途径增强免疫系统对癌症的监视作用
Karla Alvarez-Valadez,Guido Kroemer,Mojgan Djavaheri-Mergny
Karla Alvarez-Valadez
In a recent paper published in Cell, Li et al. suggest that selective serotonin reuptake inhibitors (SSRIs) antidepressants act on serotonin transporters on CD8+ T cells to enhance antitumor immunity. Beyond this mechanism, SSRIs can act on...
Characterization of the immune landscape in healthy mouse prostate and during prostate cancer progression [0.03%]
前列腺癌发生过程中健康小鼠前列腺免疫景观的特征分析
Despoina Pervizou,Joanna De Chiara,Lionel Spinelli et al.
Despoina Pervizou et al.
The immune landscape of healthy prostate and its alterations during prostate cancer (PCa) progression remain poorly characterized. Using scRNA-sequencing and multiparametric flow-cytometry analysis, we comprehensively characterized immune c...
Natural killer cells in adoptive cell therapy: current landscape of genetic engineering strategies [0.03%]
基因工程在适应性细胞治疗中的自然杀伤细胞疗法：现状与策略展望
María Burón,Anne Etxebarria,Maite Álvarez et al.
María Burón et al.
Among adoptive cell-based immunotherapies, chimeric antigen receptor (CAR) therapy has shown promising results in cancer treatment. Treatment with CAR-T cells has produced remarkable clinical responses, especially in cases of relapsed and r...
IL-21-reprogrammed Vδ1 T cells exert killing against solid tumors which is enhanced by CAR arming for off-the-shelf immunotherapy [0.03%]
白细胞介素-21重编程的Vδ1T细胞具有杀伤实体瘤的能力，并可通过嵌合抗原受体增强即用型免疫治疗的效果
Ana L Portillo,Misaal Mehboob,Genesis Snyder et al.
Ana L Portillo et al.
Cancer cell therapies have primarily focused on engineering autologous αβ T cells with chimeric antigen receptors (CARs), achieving clinical success against hematologic malignancies. However, their effectiveness against solid tumors is li...