Bi-directional support of T lymphoma and a lymphoma-associated monocyte population involving Notch signaling in mice [0.03%]
小鼠T淋巴瘤和与淋巴瘤相关单核细胞群的双向支持涉及 notch 信号通路
Sigrid Dubois,Yetzali Claudio-Medina,Jennifer L Marte et al.
Sigrid Dubois et al.
Tumor-induced manipulations of myelomonocytic differentiation have been widely reported. Here, we describe the elicitation of a tumor-supportive cell type in a T lymphoma model in mice. We observed that the development of T lymphoma coincid...
Cancer associated fibroblast-T cell crosstalk promotes purinergic synthesis in non-small cell lung cancer (NSCLC) [0.03%]
癌-associated成纤维细胞-T细胞交叉促进非小细胞肺癌(NSCLC)中嘌呤能合成
Lilian Koppensteiner,Charles Lochenie,Richard A O&#x;Connor et al.
Lilian Koppensteiner et al.
The most abundant stromal cells of the tumor microenvironment (TME), cancer-associated fibroblasts (CAFs), inhibit the cytotoxic T cell response in solid tumors. CD39 and CD73 together deplete extracellular ATP in the TME to produce adenosi...
Characterization of persistent HPV-specific activated T cells in head and neck squamous cell carcinoma [0.03%]
头颈部鳞状细胞癌中持续存在的HPV特异性活化T细胞的表征
Hiromasa Ishihara,Hirofumi Shibata,Daisuke Muraoka et al.
Hiromasa Ishihara et al.
Background: Human papillomavirus-positive oropharyngeal squamous cell carcinoma (HPV + OPSCC) generally has favorable outcomes yet remains prone to late recurrence. Durable control likely depends on persistent tumor-speci...
Single-cell sequencing profiling of intratumoral heterogeneity and immunosuppressive microenvironment in primary thyroid cancer and lymph node metastases [0.03%]
原发性甲状腺癌和淋巴结转移瘤的肿瘤内异质性和免疫抑制微环境的单细胞测序分析
Shuhang Xu,Yaorong Su,Senmin Zhang et al.
Shuhang Xu et al.
Metastasis is a major determinant of treatment failure and mortality in thyroid cancer, yet the interplay between malignant evolution and the immune microenvironment remains poorly characterized. Immunotherapy offers promise, but its effica...
Immune evasion in locally advanced mismatch repair-deficient microsatellite instability-high colorectal cancer: Reduced T-cell infiltration and upregulation of epithelial IDO1 expression [0.03%]
局部晚期错配修复缺陷型高微卫星不稳定性结直肠癌的免疫逃避：T细胞浸润减少和上皮IDO1表达上调
Sabina Niyazova,Christine Sers,Hendrik Bläker et al.
Sabina Niyazova et al.
Early-stage colorectal cancer (CRC) with confirmed microsatellite instability generally has a favorable prognosis associated with pronounced immune infiltration. However, some patients still develop metastases. The underlying mechanisms, pa...
Comparison of epcoritamab, lenalidomide, and rituximab versus usual care in relapsed/refractory follicular lymphoma [0.03%]
EPCORITAMAB、来那度胺和利妥昔单抗与复发/难治性滤泡性淋巴瘤的标准治疗的比较
Lorenzo Falchi,Martin Hutchings,David Tybor et al.
Lorenzo Falchi et al.
Patients with relapsed/refractory follicular lymphoma (R/R FL) often experience multiple disease recurrences with progressively shorter duration of remission. Chemoimmunotherapy (CIT) is commonly used for R/R FL in second-line and later set...
Clinical Trial
Oncoimmunology. 2026 Dec 31;15(1):2691549. DOI:10.1080/2162402X.2026.2691549 2026
Preclinical proof of concept for a personalized SNAP™-TIL (Specific Neo-Antigen Peptides-TIL) therapy platform [0.03%]
SNAP™-TIL（特异性新抗原肽-TIL）治疗平台的临床前概念验证
Tithi Ghosh Halder,Erin Kelley,Jorge Soria-Bustos et al.
Tithi Ghosh Halder et al.
Tumor-infiltrating lymphocyte (TIL) therapy, which involves extracting, expanding, and reinfusing immune cells to target cancer cells, has shown promise in melanoma treatment, but requires optimization for broader efficacy. The success of T...
Intratumoral enrichment and suppressive activity of DP8α regulatory T cells in human colorectal cancer [0.03%]
人结直肠癌肿瘤内的DP8α调节性T细胞富集和抑制作用
Mathilde Deiber,Cécile Deleine,Nadine Gervois-Segain et al.
Mathilde Deiber et al.
Colorectal cancer (CRC) progression is driven by dynamic interactions among tumor cells, immune infiltrates, and the gut microbiota. While regulatory T cells (Tregs) may contribute to immune suppression in CRC, the role of non-conventional ...
Esmeralda García-Torralba,Aitziber Buqué,Lorenzo Galluzzi
Esmeralda García-Torralba
The clinical management of patients with breast cancer is largely dictated by tumor stage, disease subtype and (at least in some settings) specific molecular features thereof (e.g., BRCA1 mutations, PD-L1 positivity). However, not all patie...
Ex vivo-generated conventional dendritic cells type 1 and type 2 from blood progenitors induce potent antigen-specific T-cell immunity [0.03%]
来源于血液祖细胞的外植I型和II型常规树突状细胞诱导强大的抗原特异性T细胞免疫
Jorge Cuenca-Escalona,Kevin Bos,Johanna Bödder et al.
Jorge Cuenca-Escalona et al.
While existing cancer therapies manage to reduce tumor burden, they often fail to produce durable or curative outcomes. Alternatively, cell-based approaches - particularly dendritic cell (DC) vaccines conceal the potential to elicit robust ...