DNA prime and peptide boost immunization elicits robust neoantigen-specific CD8 + T cell responses and therapeutic protection in mouse tumor models [0.03%]
基于DNA质粒和多肽免疫的neo-抗原特异性CTL应答及小鼠肿瘤模型中的治疗效果研究
Pablo Morgado-Cáceres,Francisca Hofmann-Vega,Diego Figueroa et al.
Pablo Morgado-Cáceres et al.
Therapeutic immunization against tumor neoantigens has the potential to induce potent and highly selective CD8+ T-cell-mediated antitumor immunity. Consequently, immunization strategies that generate robust neoantigen-specific T-cell respon...
Oncolytic virus OVV-03 enhances CAR-T cell therapy against glioblastoma via immune modulation and specific HER2 upregulation [0.03%]
溶瘤病毒OVV-03通过免疫调节和特异性HER2上调增强CAR-T细胞治疗胶质母细胞瘤的效果
Yi Tang,Qinzhi E,Liang Ma et al.
Yi Tang et al.
Glioblastoma (GBM) remains therapeutically challenging due to treatment resistance and immunosuppression. Oncolytic virotherapy offers a promising strategy. This study engineered OVV-03, a novel HER2-armed oncolytic vesicular stomatitis vir...
The LXRβ/NF-κB axis reprograms CAR-T cells to resist exhaustion in the tumor microenvironment [0.03%]
LXRβ/NF-κB轴重新编程CAR-T细胞以抵抗肿瘤微环境中的耗竭现象
Minji Lim,Sang-Eun Jung,Choong-Hyun Koh et al.
Minji Lim et al.
Liver X receptor β (LXRβ) is a key transcription factor involved in lipid metabolism and immune regulation, yet its functional role in tumor-infiltrating T cells remains largely unresolved. While LXRβ has been shown to suppress NF-κB ta...
Unlocking the therapeutic potential of immuno-radiotherapy: insights from preclinical and clinical research [0.03%]
免疫放射疗法的治疗潜力：来自临床前和临床研究的见解
M M Cogels,A de Caluwé,L Buisseret et al.
M M Cogels et al.
The immunomodulatory potential of radiotherapy provides a strong rationale for its combination with immunotherapies and other immunostimulatory agents. However, current combinations yield suboptimal clinical benefits. As the mechanisms behi...
Single-cell landscape of peripheral and tumor-infiltrating immune cells in HPV-negative HNSCC [0.03%]
HPV阴性喉咽癌外周血和肿瘤浸润免疫细胞单细胞图谱
Rômulo Gonçalves Agostinho Galvani,Adolfo Alexis Rojas Hidalgo,Carlos Alberto Biagi-Junior et al.
Rômulo Gonçalves Agostinho Galvani et al.
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. HPV-negative HNSCC, arising in diverse upper airway mucosal niches, is particularly aggressive, with poor 5-y survival and a limited response to immune...
A dual diacylglycerol kinase (DGK) alpha/zeta inhibitor augments the activity of human tumor infiltrating lymphocytes in in vivo and ex vivo models [0.03%]
一种新的二酰甘油激酶(DGK)α/ζ双重抑制剂在体内外模型中均可增强人类肿瘤浸润淋巴细胞的抗肿瘤活性
Phurin Areesawangkit,Karen Pei-Yi Fong,Emma Niemeyer et al.
Phurin Areesawangkit et al.
Endogenous or adoptively transferred tumor-infiltrating lymphocytes (TILs) often lose their functional capacity due to the activation of intrinsic inhibitory pathways, which then limits their ability to control tumor growth. In this study, ...
IL-37/IL-1R8 axis: a novel major mechanism of control at the interface between tumor and immune cells [0.03%]
IL-37/IL-1R8轴：肿瘤细胞和免疫细胞相互作用界面的一种新的主要调控机制
Nadine Landolina,Francesca Romana Mariotti,Enrico Munari et al.
Nadine Landolina et al.
Interleukin (IL)-37 is one of the "youngest" IL-1 family members and one of the few molecules exerting anti-inflammatory activity. Upon inflammasome activation, the cytokine precursor is converted into its mature form, which acts intracellu...
Neutrophil extracellular trap inhibition revitalizes PDAC immunotherapy responsiveness via reduced fibrosis and TCF1+CD8+ progenitor T-cell expansion [0.03%]
中性粒细胞胞外陷阱抑制通过减少纤维化和增加TCF1+CD8+祖T细胞的扩增来增强胰腺导管腺癌免疫治疗的敏感性
Britney Niemann,Abby Ivey,Quinn Hopen et al.
Britney Niemann et al.
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with poor survival. The immunosuppressive tumor microenvironment (TME) drives resistance to therapy, including immunotherapy. This may be, in part, mediated by the formation o...
Mild microwave hyperthermia promotes mitotic catastrophe, induces time-delayed cGAS-STING activation and restores sensitivity to anti-PDL1 therapy in Pan02 pancreatic cancer model [0.03%]
微波轻度热疗可促进癌细胞进入有丝分裂灾难，诱导cGAS-STING通路延时激活并恢复PD-L1抗体在胰腺癌中的疗效
Na Li,Jiamin He,Mengjiao Chen et al.
Na Li et al.
Pancreatic ductal adenocarcinoma (PDAC) responds poorly to immune checkpoint inhibitors (ICIs), representingindicating an unmet clinical need. Hyperthermia therapy, an approved anti-cancer approach with limited adverse effects, has been sug...
Novel immunotheranostic FAP-inhibitor target modules for imaging and elimination of FAP-positive cells by UniCAR T-cells [0.03%]
一种新型免疫诊疗FAP抑制剂靶点模块 用于UniCAR T细胞成像和清除FAP阳性细胞
Hugo Boutier,Jürgen Kogler,Liliana R Loureiro et al.
Hugo Boutier et al.
The fibroblast activation protein alpha (FAPα) is overexpressed in the tumor microenvironment of most solid cancers and, in some cases, in cancer cells, making it an interesting target for theranostic applications. T-cells modified to expr...