Monocytes acquire a tumor-associated IL1B program upon encountering patient-derived colon cancer organoids [0.03%]
单核细胞在遇到患者衍生的结肠癌类器官时获得与肿瘤相关的IL1B程序
Bianca M Balzasch,Andreas von Kries,Saskia Hüll et al.
Bianca M Balzasch et al.
Tumor-associated macrophages (TAMs) and monocytes that accumulate in colorectal cancer (CRC) play a crucial role in shaping the tumor microenvironment (TME) and anti-tumor immune responses. Although TAMs have been linked to both pro- and an...
Trial Watch - bispecific T cell engagers and higher-order multispecific immunotherapeutics [0.03%]
试验观察：双特异性T细胞衔接分子及更高级的多种免疫治疗药物
Enfu Xue,Xiaolian Deng,Flora Doffe et al.
Enfu Xue et al.
Over the past decades, cancer immunotherapy has evolved into clinical practice, with bispecific T cell engagers (TCEs) and other higher-order multispecific immunotherapeutics emerging as approaches for precision immune modulation. These eng...
Enhancing immunogenic cell death by targeting the GPX4-ZP3 immune checkpoint [0.03%]
靶向GPX4-ZP3免疫检查点以增强免疫原性细胞死亡
Daolin Tang,Rui Kang,Peng Liu et al.
Daolin Tang et al.
Cédric Rébé,Anaïs Perrichet,François Ghiringhelli
Cédric Rébé
Interleukin (IL)-1β is known to promote lung cancer growth in both humans and mice. However, in the context of the current standard of care, which includes chemotherapy and immune checkpoint inhibitors, IL-1β can overcome resistance. ...
In vitro generated macrophages reflect the immunosuppressive phenotype of in vivo glioblastoma-associated macrophages [0.03%]
体外生成的巨噬细胞反映了体内胶质母细胞瘤相关巨噬细胞的免疫抑制表型
Matthew Nazzaro,Elaine R Mardis,Mykyta Artomov et al.
Matthew Nazzaro et al.
Glioblastoma (GBM) is the most common primary central nervous system tumor with a dismal prognosis and limited treatment options. Recent success utilizing immunotherapies for treating other solid tumors have been largely unsuccessful in GBM...
Killing cancer takes guts: lessons learned from the manipulation of gut microbiome and immunotherapy for the future of urothelial carcinoma [0.03%]
杀灭癌症需从“肠”计议：肠道菌群与免疫治疗对尿路上皮癌未来发展的启示
Nihaal Reddy,Kire Lau,Jacob Naman et al.
Nihaal Reddy et al.
Urothelial carcinoma (UC) remains a common cancer with significant morbidity and mortality worldwide. Immune checkpoint inhibitors (ICIs) have helped revolutionize the treatment of UC, and there is growing evidence suggesting the crucial ro...
NK cell-mediated tumor cell killing by bispecific innate cell engagers induces ADCC-mediated activation of primary human dendritic cells [0.03%]
双特异性固有细胞参与剂介导的自然杀伤细胞肿瘤细胞杀伤作用诱导原代人树突状细胞活化中的ADCC效应
Lukas Heger,Tomasz Kaszubowski,Lukas Amon et al.
Lukas Heger et al.
Bispecific antibodies are used for the treatment of hematological malignancies as well as solid tumors. One of their main effector mechanisms is the recruitment of effector cells such as CD8+ T cells and CD16A+ NK cells to tumor cells. Bisp...
Multi-platform analysis of the tumor immune microenvironment associated with breast cancer subtypes [0.03%]
与乳腺癌亚型相关的肿瘤免疫微环境的多平台分析
Lilly Anne Torland,Jürgen Geisler,Youness Azimzade et al.
Lilly Anne Torland et al.
Breast cancer is genetically and histologically heterogenous, and is influenced by a variety of factors, including the tumor microenvironment (TME). The PAM50 subtypes; Luminal A, Luminal B, Normal-like, Basal-like and Her2-enriched, are as...
Radiotherapy-induced abscopal effects in immune checkpoint inhibitor-refractory metastatic disease: results from a large multicenter real-world cohort study [0.03%]
一项大规模真实世界多中心队列研究：免疫检查点抑制剂治疗难治性转移性疾病患者的放疗诱发的远隔效应结果
Maike Trommer,Alexander Rühle,Allison Lamrani et al.
Maike Trommer et al.
Combining radiotherapy with immune checkpoint inhibitors (RT-ICI) triggers systemic antitumor responses, such as abscopal effects (AbE). Predictors of AbE and its impact on survival in real-world settings remain poorly defined. This multice...
Multicenter Study
Oncoimmunology. 2026 Dec 31;15(1):2610529. DOI:10.1080/2162402X.2025.2610529 2026