Spatial transcriptomics unveils immune cellular ecosystems associated with patient survival in diffuse large B-cell lymphoma [0.03%]
空间转录组学揭示与弥漫性大B细胞淋巴瘤患者生存率相关的免疫细胞生态系统
Alba Diaz-Herrero,Héctor Fernando Pelaez-Prestel,Lucile Massenet-Regad et al.
Alba Diaz-Herrero et al.
Diffuse large B-cell Lymphoma (DLBCL) is the most prevalent subtype of non-Hodgkin's lymphoma for which current therapeutic strategies remain insufficient, in part owing to heterogeneity in tumor biology and the immune microenvironment. The...
PARP7 inhibition and a STING agonist potentiate radiation-induced immunogenicity in glioblastoma [0.03%]
抑制PARP7和刺激STING激动剂可增强放射治疗对胶质母细胞瘤的免疫原性作用
Luca Lippert,Ava Kleinwächter,Anna Ohradanova-Repic et al.
Luca Lippert et al.
Glioblastoma (GBM) is the most lethal form of brain cancer with an immunosuppressive tumor microenvironment (TME). Radio- and chemotherapy can modify the TME and elicit anti-tumor immunity through the STING and type I interferon (IFN-I) pat...
Alistipes and Eggerthella shape the response to oncolytic adenovirus therapy in mice and humans through short-chain fatty acid metabolism [0.03%]
短链脂肪酸代谢塑造了小鼠和人类肿瘤患者对溶瘤腺病毒治疗的反应机制：阿利斯特菌属和伊格尔特菌属的作用
Mirte van der Heijden,James Hugo Armstrong Clubb,Pande Putu Erawijantari et al.
Mirte van der Heijden et al.
Accumulating evidence implicates the microbiome as an important determinant of clinical outcomes in cancer therapies; however, the role of the microbiome in oncolytic virus therapy remains largely unexplored. We investigated the gut microbi...
Restoring dendritic cell migration: a gut reaction to boost vaccine efficacy in aging [0.03%]
恢复树突细胞迁移：肠道的反应可增强疫苗对衰老机体的有效性
Liwei Zhao,Oliver Kepp,Guido Kroemer et al.
Liwei Zhao et al.
Aging impairs vaccine responses. Dai et al. reported that defective cDC2 migration in immunized old mice, diminishing humoral and cellular immunity. Oral yeast-derived nanoparticles restore DC migration and vaccine efficacy. These findings ...
Telomere damage enhances immunogenicity of neuroblastoma and accelerates response to anti-PD-L1 treatment [0.03%]
端粒损伤可增强神经母细胞瘤的免疫原性并加速抗PD-L1治疗的疗效响应
Stefanie Höppner,Lisa Werr,Beata Szilagyi et al.
Stefanie Höppner et al.
Telomerase is active in the majority of high-risk neuroblastomas, a pediatric tumor associated with poor patient outcomes. In other cancer types, resistance to immune checkpoint blockade was overcome by induction of telomere dysfunction usi...
Early local immune activation following intra-operative radiotherapy in human breast tissue [0.03%]
术中放疗后人乳腺组织早期局部免疫激活反应
Anna Tiefenthaller,Nikko Brix,Roman Hennel et al.
Anna Tiefenthaller et al.
The local immune effects of cancer radiotherapy remain poorly characterized in humans due to limited access to irradiated tissue. Mechanistic insights largely derive from preclinical models employing tumor-intact, neoadjuvant-like settings....
Pharmacological inhibition of MAPK P38α rescues the immune defect of dendritic cells affected by the FPR1 loss-of-function polymorphism rs867228 [0.03%]
MAPK P38α的药理学抑制可补救FPR1失活多态性rs867228影响的树突状细胞的免疫缺陷
Liwei Zhao,Oliver Kepp,Peng Liu et al.
Liwei Zhao et al.
Sialic acid cis-ligand dynamics modulate Siglec-7 and -9 function and affect Siglec-7/9 co-blockade to potentiate natural killer cell anti-tumor activity [0.03%]
唾液酸顺式配体动力学调节Siglec-7和Siglec-9的功能并影响Siglec-7/Siglec-9协同阻断以增强自然杀伤细胞的抗肿瘤活性
Jesper van Eck van der Sluijs,Anne H C Valk,Eline J H van Houtum et al.
Jesper van Eck van der Sluijs et al.
The glyco-immune checkpoints Siglec-7 and Siglec-9 have received considerable interest as targets for cancer immunotherapy. How Siglec-7/9-sialic acid cis-interactions on immune cells influence trans-signaling induced by tumor cells and whe...
Integrating tumor and immune cell transcriptomics to predict immune checkpoint inhibitor primary resistance in metastatic melanoma [0.03%]
整合肿瘤和免疫细胞转录组学以预测转移性黑色素瘤免疫检查点抑制剂原发耐药性
Juan Luis Onieva,Elisabeth Pérez-Ruiz,Ville Vilkki et al.
Juan Luis Onieva et al.
The emergence of immune checkpoint inhibitors (ICIs) has transformed the treatment landscape of metastatic melanoma. However, despite its success, reliable biomarkers for predicting primary resistance are not available in clinical practice....
Sex determines the natural killer cell-mediated immunity against pancreatic cancer [0.03%]
性别决定胰腺癌的自然杀伤细胞介导的免疫应答
Elise Arlt,Nadine Bley,Alexander Rausch et al.
Elise Arlt et al.
Pancreatic ductal adenocarcinoma (PDAC) ranks among the most aggressive malignancies and exhibits a higher prevalence and poorer prognosis in male patients. While both the importance of natural killer (NK) cells in anti-tumor immunity and s...