Leptin decreases Th17/Treg ratio to facilitate neuroblastoma via inhibiting long-chain fatty acid catabolism in tumor cells [0.03%]
脂联素通过抑制长链脂肪酸分解代谢降低Th17/Treg比例促进神经母细胞瘤的发展
Meng Li,Di Li,Hai-Yun Wang et al.
Meng Li et al.
The exploration of therapeutic targets in neuroblastoma (NB), which needs more attempts, can benefit patients with high-risk NB. Based on metabolomic and transcriptomic data in mediastinal NB tissues, we found that the content of long-chain...
Isolation of a tumor neoantigen specific CD8+ TCR from a skin biopsy of a vaccination site [0.03%]
从疫苗接种部位皮肤活检标本中分离肿瘤新抗原特异性CD8+tcr
Maria Paula Roberti,Pornpimol Charoentong,Yanhong Lyu et al.
Maria Paula Roberti et al.
T cells that recognize tumor-specific mutations are crucial for cancer immunosurveillance and in adoptive transfer of TILs or transgenic-TCR T cell products. However, their challenging identification and isolation limits their use in clinic...
Identification of TTLL8, POTEE, and PKMYT1 as immunogenic cancer-associated antigens and potential immunotherapy targets in ovarian cancer [0.03%]
TTLL8、POTEE和PKMYT1是卵巢癌的免疫相关抗癌原及潜在免疫治疗靶点
Esen Yonca Bassoy,Remya Raja,Thomas E Rubino Jr et al.
Esen Yonca Bassoy et al.
Most high-grade serous ovarian cancers (OC) do not respond to current immunotherapies. To identify potential new actionable tumor antigens in OC, we performed immunopeptidomics on a human OC cell line expressing the HLA-A02:01 haplotype, wh...
Paradoxical control of multifocal mammary oncogenesis by radiation therapy [0.03%]
放射治疗对多灶性乳腺肿瘤发生的矛盾调控作用
Lorenzo Galluzzi,Aitziber Buqué
Lorenzo Galluzzi
In an immunocompetent mouse model of multifocal, metachronous HR+ mammary carcinogenesis, we have recently demonstrated that a superior control of primary neoplastic lesions by focal radiotherapy does not necessarily translate into improved...
Liver metastases of colorectal cancer contain different subsets of tissue-resident memory CD8 T cells correlated with a distinct risk of relapse following surgery [0.03%]
结直肠癌肝转移灶中存在不同亚群的组织驻留记忆CD8+t细胞，与术后不同的复发风险相关
Syrine Abdeljaoued,Alexandre Doussot,Marie Kroemer et al.
Syrine Abdeljaoued et al.
Tissue-resident memory (TRM) T cells have emerged as key players in cancer immunosurveillance, and their presence has been linked to a favorable clinical outcome in solid cancer patients. Liver metastases exhibit a highly immunosuppressive ...
Current landscape and future prospects of interleukin-2 receptor (IL-2R) agonists in cancer immunotherapy [0.03%]
癌症免疫治疗中白细胞介素-2受体(IL-2R)激动剂的现状和前景
Kengo Tanigawa,William L Redmond
Kengo Tanigawa
Immune checkpoint blockade (ICB) has significantly improved the survival for many patients with advanced malignancy. However, fewer than 50% of patients benefit from ICB, highlighting the need for more effective immunotherapy options. High-...
Calpain 2 regulates IL-1α secretion and inhibits tumor development via modulating calpain 1 expression in the tumor microenvironment [0.03%]
钙蛋白酶2通过调节肿瘤微环境中钙蛋白酶1的表达来调控IL-1α释放并抑制肿瘤发生
Zuhairah Binte Hanafi,Yu Mei,Huey Yee Teo et al.
Zuhairah Binte Hanafi et al.
Tumor-promoting inflammation significantly impacts cancer progression, and targeting inflammatory cytokines has emerged as a promising therapeutic approach in clinical trials. Interleukin (IL)-1α, a member of the IL-1 cytokine family, play...
Correction [0.03%]
改正通知书
Published Erratum
Oncoimmunology. 2025 Dec;14(1):2444174. DOI:10.1080/2162402X.2024.2444174 2025
Dual-targeted STAb-T cells secreting BCMA and CD19 T cell engagers for improved control of haematological cancers [0.03%]
一种新型双靶向STAb-T细胞分泌针对B细胞成熟抗原和CD19的T细胞衔接器，可有效改善血液系统恶性肿瘤的治疗效果
Miriam Velasco-Sidro,Javier Arroyo-Ródenas,Laura Díez-Alonso et al.
Miriam Velasco-Sidro et al.
Despite recent advances in immunotherapy against B cell malignancies such as BCMA (B cell maturation antigen) and CD19-targeted treatments using soluble T cell-engaging (TCE) antibodies or chimeric antigen receptor T cells (CAR-T), there is...
Induction of cell death in malignant cells and regulatory T cells in the tumor microenvironment by targeting CD137 [0.03%]
靶向CD137诱导恶性细胞和肿瘤微环境中调节性T细胞的死亡
Rui Sun,Kang Yi Lee,Yu Mei et al.
Rui Sun et al.
Regulatory T cells (Tregs) contribute significantly to the immunosuppressive nature of the tumor microenvironment which is a main barrier for immunotherapies of solid cancers. Reducing Treg numbers enhances anti-tumor immune responses but c...