An orthotopic organoid-based model to study early CD8⁺ T cell dysfunction and immunotherapy response in colorectal cancer [0.03%]
一种正确定位的类器官模型：研究结直肠癌早期CD8⁺T细胞功能障碍和免疫治疗反应
Lorenzo Lucantonio,Ludovica Schiano,Francesca Sozio et al.
Lorenzo Lucantonio et al.
Colorectal cancer (CRC) treatment represents a major clinical challenge, with immunotherapy providing durable responses only in a minority of patients. A deeper understanding of CD8⁺ T cell exhaustion and its contribution to immune checkpo...
Reshaping immunotherapy sequencing strategy: equivalent survival with induction plus consolidation vs. consolidation-only strategy in unresectable stage III NSCLC [0.03%]
重塑免疫治疗顺序策略：诱导联合巩固与单纯巩固方案在不可切除III期NSCLC中生存结局相当
Wenlu Chen,Anqi Zhao,Yu Liang et al.
Wenlu Chen et al.
Objective: To compare the efficacy and safety of a sequential combination of chemoradiotherapy (CRT) with immune checkpoint inhibitors (ICIs) administered as induction plus consolidation versus consolidation-only in patie...
Multicenter Study
Oncoimmunology. 2026 Dec 31;15(1):2670221. DOI:10.1080/2162402X.2026.2670221 2026
Novel multiplex immunofluorescence-based tumor inflammation score provides apparent predictive biomarker in a phase I/II study of pembrolizumab with gemcitabine in patients with previously-treated advanced non-small cell lung cancer (NSCLC) [0.03%]
新型多重免疫荧光基肿瘤炎症评分在帕博利珠单抗联合吉西他滨治疗经治晚期非小细胞肺癌（NSCLC）患者I/II期研究中提供显著的预测生物标志物作用
Rachel E Sanborn,Shawn M Jensen,Christopher Paustian et al.
Rachel E Sanborn et al.
Retrospective characterization of cell‒cell relationships in the tumor microenvironment provides significantly better predictive power than PD-L1 expression, tumor mutational burden (TMB), or gene expression profiles. In this small study a...
Clinical Trial
Oncoimmunology. 2026 Dec 31;15(1):2661444. DOI:10.1080/2162402X.2026.2661444 2026
Deep learning based on CD3 histological slides for prediction of colon cancer outcome: analysis of three international stage III colon cancer cohorts [0.03%]
基于CD3组织切片的深度学习预测结肠癌预后：国际三期结肠癌队列分析
Julie Lécuelle,Caroline Truntzer,Debora Basile et al.
Julie Lécuelle et al.
Prognostic stratification in stage III colon cancer remains poor, despite treatment advances. Tumor-infiltrating lymphocytes, particularly CD3+ T cells, are potential prognostic markers, but manual assessment is labor-intensive and not robu...
Sex-based considerations in the choice for a TLR9 or TLR7/8 agonist to arm the sentinel lymph node in early-stage melanoma [0.03%]
早期黑色素瘤中基于性别选择TLR9或TLR7/8激动剂以武装滤泡淋巴结的考虑因素
Jessica C L Notohardjo,Elisa C Toffoli,Tara Muijlwijk et al.
Jessica C L Notohardjo et al.
Intradermal delivery of the Toll-like receptor (TLR)-9 agonist agatolimod/CPG7909, prior to sentinel lymph node (SLN) biopsy was previously shown to induce locoregional and systemic immunity, reduce tumor-involved SLN rates, and improve rec...
Flora Doffe,Xiaolian Deng,Zhe Shen et al.
Flora Doffe et al.
Antibody-drug conjugates (ADCs) combine the target specificity of monoclonal antibodies with the cytotoxic potency of small-molecule payloads. In recent years ADCs have emerged as a clinically validated component of modern precision oncolog...
Pleiotropic effects of BET inhibition broadly boost tumor immunogenicity to CD8+ T cells [0.03%]
BET抑制的多效性可广泛增强肿瘤的免疫原性以促进CD8+t细胞作用
Jeroen Melief,Lucas Baldran-Groves,Marc-Antoine Gerault et al.
Jeroen Melief et al.
BET inhibitors (BETi) have shown potential to augment tumor immunogenicity in melanoma. However, conflicting evidence exists regarding their precise mechanism of action, and their overall impact on melanoma immunogenicity and antitumoral T ...
Transglutaminase 2 regulates innate immunity: mechanisms and therapeutic implications [0.03%]
转谷氨酰胺酶2调节先天性免疫：机制及治疗意义
Manuela D&#x;Eletto,Luca Occhigrossi,Fiorella Colasuonno et al.
Manuela D&#x;Eletto et al.
Innate immunity constitutes the primary barrier against invading pathogens and plays a crucial role in coordinating the initiation and modulation of adaptive immune responses. Transglutaminase 2 (TG2), a ubiquitously expressed multifunction...
Spatial transcriptomics unveils immune cellular ecosystems associated with patient survival in diffuse large B-cell lymphoma [0.03%]
空间转录组学揭示与弥漫性大B细胞淋巴瘤患者生存率相关的免疫细胞生态系统
Alba Diaz-Herrero,Héctor Fernando Pelaez-Prestel,Lucile Massenet-Regad et al.
Alba Diaz-Herrero et al.
Diffuse large B-cell Lymphoma (DLBCL) is the most prevalent subtype of non-Hodgkin's lymphoma for which current therapeutic strategies remain insufficient, in part owing to heterogeneity in tumor biology and the immune microenvironment. The...
PARP7 inhibition and a STING agonist potentiate radiation-induced immunogenicity in glioblastoma [0.03%]
抑制PARP7和刺激STING激动剂可增强放射治疗对胶质母细胞瘤的免疫原性作用
Luca Lippert,Ava Kleinwächter,Anna Ohradanova-Repic et al.
Luca Lippert et al.
Glioblastoma (GBM) is the most lethal form of brain cancer with an immunosuppressive tumor microenvironment (TME). Radio- and chemotherapy can modify the TME and elicit anti-tumor immunity through the STING and type I interferon (IFN-I) pat...