Preclinical and clinical studies on CAR-NK cell therapy: latest update from 2025 ASH Annual Meeting [0.03%]
2025年ASH年会CAR-NK细胞治疗的最新研究进展
Hanxi Luo,Yiyang Ding,Xiangyu Zhao
Hanxi Luo
Chimeric antigen receptor-engineered natural killer (CAR-NK) cells are emerging as an off-the-shelf immunotherapy for hematologic malignancies, supported by early clinical data and a favorable safety profile. Compared with CAR-T therapy, CA...
Hierarchies of resistance to DNA damage response inhibitors: from pathway restoration to replication stress tolerance [0.03%]
DNA修复抑制剂的耐药层级：从修复通路重建至复制压力耐受性
Valentina Morgera,Antonia Feola,Antonella Romano et al.
Valentina Morgera et al.
DNA damage response (DDR) inhibitors have reshaped precision oncology by exploiting tumor-specific vulnerabilities in genome maintenance and replication stress control. The clinical success of poly(ADP-ribose) polymerase (PARP) inhibitors-p...
Inhibition of protein kinase CK2 remodels the tumor immune microenvironment and sensitizes lung cancer to PD-L1 blockade [0.03%]
蛋白激酶CK2抑制可重塑肿瘤免疫微环境并使肺癌对PD-L1阻断敏感化
Sijia Zhang,Lihua Luo,Yangang Qu et al.
Sijia Zhang et al.
Background: Protein kinase CK2 is a pleiotropic oncogenic serine/threonine kinase implicated in multiple cancer-associated signaling pathways. However, its role in shaping the tumor immune microenvironment (TIME) and regu...
ISX-TWIST1 reprograms CD47-inflammasome signaling to reshape the immune microenvironment in liver cancer [0.03%]
ISX-TWIST1 通过重新编程 CD47-炎性小体信号来重塑肝癌免疫微环境
Li-Ting Wang,Ming-Hong Lin,Yi-Chuan Li et al.
Li-Ting Wang et al.
Immunotherapies have shown promise effectiveness in cancer treatment, yet the complex tumor microenvironment poses challenges to their efficacy. The interaction between immune checkpoints in malignant and immune cells is crucial for cancer ...
Combining circulating tumor cell and circulating cell-free DNA analyses broadens clinical applicability of liquid biopsy in high grade serous tubo-ovarian carcinoma [0.03%]
循环肿瘤细胞和循环游离DNA分析的结合可提高液态活检在高级别浆液性输卵管卵巢癌中的临床应用范围
Beatrice Cavina,Simona Corrà,Camelia Alexandra Coadă et al.
Beatrice Cavina et al.
Liquid biopsy is a promising strategy for detecting and monitoring neoplastic diseases, with circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) being the most common objects of investigation. Studies are mainly focusing on the...
Metabolic drivers of genome instability in cancer: mechanisms and therapeutic opportunities [0.03%]
癌症基因组不稳定的代谢驱动因素：机制和治疗机会
Yu-Shun Wang,Li-Heng Qian,Cui-Cui Liu et al.
Yu-Shun Wang et al.
Metabolic reprogramming and genome instability represent two fundamental hallmarks of cancer. Emerging studies now demonstrate that specific metabolic alterations directly fuel replication stress, DNA damage, and compromised DNA damage resp...
Decoding the spatiotemporal characteristics of ferroptosis: reshaping tumour therapeutic strategies [0.03%]
铁死亡时空特征解析及重塑肿瘤治疗策略
Lizhou Song,Yue Shu,Tian Zhou et al.
Lizhou Song et al.
The resistance to treatment and the high chance of death associated with cancer still remain key problems that need breakthrough in biology and medicine. Ferroptosis is a newly discovered form of regulated cell death that is driven by iron ...
Correction: Novel non-viral in vivo CAR-T therapies: latest updates from the 2025 ASH annual meeting [0.03%]
Correction：新型非病毒体内CAR-T疗法：2025年ASH年会上的最新更新
Bin Xue,Yifan Liu,Aibin Liang et al.
Bin Xue et al.
Published Erratum
Experimental hematology & oncology. 2026 Apr 6;15(1):41. DOI:10.1186/s40164-026-00772-6 2026
Multi-omics analysis of patient-derived organoids reveals that E3 ligase COP1 promotes liver metastasis and oxaliplatin resistance in colorectal cancer through LUZP1 degradation and MYL9 phosphorylation [0.03%]
基于患者来源的类器官多组学分析揭示E3泛素连接酶COP1通过LUZP1降解和MYL9磷酸化促进结直肠癌肝转移和奥沙利铂耐药性
Ruijia Zhang,Wenqin Luo,Qikai Zhou et al.
Ruijia Zhang et al.
Colorectal cancer liver metastasis (CRLM) and chemotherapy resistance remain major clinical challenges, with the underlying molecular mechanisms yet to be fully elucidated. In this study, based on analyses of five initial clinical cohorts f...
Clinical and translational advances in regulatory T cell-based strategies in allogeneic hematopoietic stem cell transplantation: highlights from ASH 2025 [0.03%]
适应性调节T细胞在同种异体造血干细胞移植中的临床及转化研究进展：来自2025年ASH会议的亮点报告
Somayeh Yazdanparast,Saeid Abroun,Tahereh Rostami et al.
Somayeh Yazdanparast et al.
Regulatory T cells (Tregs), winners of the 2025 Nobel Prize in Physiology or Medicine, emerged as an unsung giant of peripheral immune tolerance after allogeneic hematopoietic stem cell transplantation (allo-HSCT). These cells exert influen...