Cellular adhesion-dependent 3D morphogenesis indicating brain tumor aggressiveness and chemosensitivity in spherical cavity culture [0.03%]
基于细胞粘附的三维形态发生的球形腔培养指示脑肿瘤的侵袭性和化学敏感性
Thuy Huynh,Jieun Kim,Sarnai Amartumur et al.
Thuy Huynh et al.
Malignancies of the nervous system remain a critical challenge in oncology, contributing substantially to cancer-related mortality in children and adults. Their aggressive behavior is influenced by adhesion heterogeneity of the tumor cells,...
AAV-delivered miRNA-gated Cre circuits enable programmable gene activation in AFP-active liver tumor models [0.03%]
利用AAV递送的miRNA门控Cre电路在AFP活性的肝肿瘤模型中实现程序化基因激活
Xiaoting Zhang,Congcong Cao,Zeqi Huang et al.
Xiaoting Zhang et al.
Selective therapeutic gene activation in tumors remains challenging because tumor-enriched promoters often exhibit basal activity in non-target cells and may not fully capture intratumoral heterogeneity. In addition, direct promoter-driven ...
The spatial and multi-omic landscape of Down syndrome leukemogenesis: moving beyond cellular heterogeneity [0.03%]
唐氏综合症白血病发生的空间和多组学景观：超越细胞异质性
Edoardo Peroni,Rosario Amato,Martina Bado et al.
Edoardo Peroni et al.
Down syndrome (DS) confers a developmentally rooted predisposition to both myeloid and lymphoid leukemias, particularly myeloid leukemia associated with DS (ML-DS) and acute lymphoblastic leukemia associated with DS (ALL-DS). While trisomy ...
Spatially resolved transcriptomic profiling of myelofibrosis spleen reveals compartment specific niche programs [0.03%]
空间分辨的转录谱分析发现脾脏中室特异性骨髓纤维化生态位程序
Edoardo Peroni,Marco Pizzi,Marco Basso et al.
Edoardo Peroni et al.
Myelofibrosis (MF) splenomegaly reflects not only extramedullary hematopoiesis (EMH) but a compartmental organization of the splenic microenvironment into spatially distinct niches. Using Spatial whole transcriptome profiling on FFPE spleen...
Emerging agents and regimens for myeloproliferative neoplasms: updates from ASH 2025 Annual Meeting [0.03%]
我的血液学：2025年ASH年会关于骨髓增殖性肿瘤的新药和新方案的更新
Tiantian Zhang,Heng Jiang,Delong Liu
Tiantian Zhang
Current Myeloproliferative neoplasm (MPN) therapies provide meaningful symptom and event-risk control but are limited by infrequent molecular remissions, treatment-limiting cytopenias (particularly anemia), and continued reliance on non-mut...
Arsenic trioxide promotes a glue‑like interaction to drive STUB1-mediated NPM-ALK degradation in ALK+ ALCL [0.03%]
三氧化二砷通过促进胶水样的相互作用来驱动STUB1介导的NPM-ALK降解在ALK阳性ALCL中的作用
Guiming Li,Jun Wang,Shiguang Ye et al.
Guiming Li et al.
The nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) fusion constitutively activates ALK tyrosine kinase, driving oncogenesis in anaplastic large cell lymphoma (ALCL). While arsenic trioxide (ATO) exhibits therapeutic potential, its preci...
Emerging venetoclax plus hypomethylating agent-based triplet regimens in newly diagnosed acute myeloid leukemia: updates from the 2025 ASH Annual Meeting [0.03%]
2025年ASH年会中关于新诊断急性髓系白血病的维奈克拉联合低甲基化药物为基础的三药方案的新进展
Haibo Yu,Ting Shi,Hong-Hu Zhu
Haibo Yu
Venetoclax (VEN) combined with a hypomethylating agent (HMA) has become a standard-of-care frontline therapy for unfit patients with newly diagnosed acute myeloid leukemia (ND AML). The VIALE-A trial established the clinical benefit of VEN ...
Frontline T cell-redirecting therapies in newly diagnosed multiple myeloma: key signals from the 2025 ASH Annual Meeting [0.03%]
一线T细胞重定向疗法在新诊断的多发性骨髓瘤中的作用：2025年ASH年会的关键信号
Huixing Zhou,Xiaoyun Jin,Wenming Chen et al.
Huixing Zhou et al.
Early frontline data presented at the 2025 ASH Annual Meeting suggest that T cell-redirecting strategies, including chimeric antigen receptor (CAR)-T cells and bispecific antibodies (BsAbs), can induce rapid, high rates of minimal residual ...
Optimizing the timing of JAK1 inhibition preserves the anti-tumor efficacy of radioimmunotherapy in lung cancer by preventing T cell exhaustion [0.03%]
JAK1抑制时机的优化通过防止T细胞耗竭来保持放射免疫治疗在肺癌中的抗肿瘤疗效
Zhiru Gao,Linlin Yang,Linlin Wang
Zhiru Gao
JAK1 inhibitors are widely used in hematologic malignancies and autoimmune diseases, their potential in combination with immunotherapy for solid tumors such as lung cancer is increasingly being recognized. The combination of radiotherapy an...
Cystathionine beta-synthase promotes anoikis resistance and transcoelomic metastasis in ovarian cancer via SP1- ITGB1 regulation [0.03%]
半胱硫醚-beta-合酶通过SP1-ITGB1调节促进卵巢癌上皮悬滴和腹膜转移
Pallab Shaw,Arpan Dey Bhowmik,Akrit Pran Jaswal et al.
Pallab Shaw et al.
Anoikis resistance is crucial for ovarian cancer (OvCa) transcoelomic metastasis, during which exfoliated OvCa cells survive as spheroids before invading the omentum. Here, we demonstrate that cystathionine β-synthase (CBS), an H2S-produci...