The spatial and multi-omic landscape of Down syndrome leukemogenesis: moving beyond cellular heterogeneity
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Down syndrome (DS) confers a developmentally rooted predisposition to both myeloid and lymphoid leukemias, particularly myeloid leukemia associated with DS (ML-DS) and acute lymphoblastic leukemia associated with DS (ALL-DS). While trisomy 21-driven gene dosag... ...
