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Spatially resolved transcriptomic profiling of myelofibrosis spleen reveals compartment specific niche programs

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Myelofibrosis (MF) splenomegaly reflects not only extramedullary hematopoiesis (EMH) but a compartmental organization of the splenic microenvironment into spatially distinct niches. Using Spatial whole transcriptome profiling on FFPE spleen tissue from three M... ...