Distinct regulatory functions and biological roles of lncRNA splice variants [0.03%]
长非编码 RNA 剪接变异体的特异性调控功能及生物学作用
Muhammad Riaz Khan,Mariano Avino,Raymund J Wellinger et al.
Muhammad Riaz Khan et al.
Alternative splicing (AS) of RNA molecules is a key contributor to transcriptome diversity. In humans, 90%-95% of multi-exon genes produce alternatively spliced RNA transcripts. Therefore, every single gene has the opportunity of producing ...
STAT3 silencing by an aptamer-based strategy hampers the crosstalk between NSCLC cells and cancer-associated fibroblasts [0.03%]
基于适配体的STAT3沉默策略可干扰非小细胞肺癌细胞与癌相关成纤维母细胞间的串扰
Maria L Ibba,Giuseppe Ciccone,Deborah Rotoli et al.
Maria L Ibba et al.
The identification of new effective therapeutic options for non-small-cell lung cancer (NSCLC) represents a crucial challenge in oncology. Recent studies indicate that cancer-associated fibroblasts (CAFs) participate in tumor progression by...
Mechanical stimuli-induced CCL2 restores adult mouse cells to regenerate hair follicles [0.03%]
机械刺激诱导的CCL2使小鼠成人细胞恢复毛囊再生能力
Wang Wu,Wei Zhou,Jingwei Jiang et al.
Wang Wu et al.
Aged cells have declined regenerative ability when subjected to environmental insult. Here we elucidate the mechanism by which mechanical stimulus induces hair regeneration at the microenvironmental regulation level using the hair plucking ...
Extracellular vesicle microRNA and protein cargo profiling in three clinical-grade stem cell products reveals key functional pathways [0.03%]
临床级干细胞产品的细胞外囊泡微rna和蛋白质货物分析揭示关键功能通路
Ramana Vaka,Sandrine Parent,Yousef Risha et al.
Ramana Vaka et al.
The cell origin-specific payloads within extracellular vesicles (EVs) mediate therapeutic bioactivity for a wide variety of stem cell types. In this study, we profiled the microRNA (miRNA) and protein cargos found within EVs produced by thr...
Efficient correction of ABCA4 variants by CRISPR-Cas9 in hiPSCs derived from Stargardt disease patients [0.03%]
CRISPR-Cas9高效修正Stargardt病患者诱导多能干细胞来源的ABCA4变异型
Laura Siles,Sheila Ruiz-Nogales,Arnau Navinés-Ferrer et al.
Laura Siles et al.
Inherited retinal dystrophies comprise a broad group of genetic eye diseases without effective treatment. Among them, Stargardt disease is the second most prevalent pathology. This pathology triggers progressive retinal degeneration and vis...
tRF-1001: A potential therapeutic target for ocular neovascular diseases [0.03%]
针对眼部新生血管性疾病的新型治疗靶点tRF-1001研究
Pradeep Reddy Cingaram
Pradeep Reddy Cingaram
Inhibition of adenovirus replication by CRISPR-Cas9-mediated targeting of the viral E1A gene [0.03%]
利用CRISPR-Cas9技术靶向腺病毒E1A基因以抑制其复制
Zrinka Didara,Florian Reithofer,Karina Zöttl et al.
Zrinka Didara et al.
DNA-targeting CRISPR-Cas systems are able to cleave dsDNA in mammalian cells. Accordingly, they have been employed to target the genomes of dsDNA viruses, mostly when present in cells in a non-replicative state with low copy numbers. Howeve...
Differential effects of SARM1 inhibition in traumatic glaucoma and EAE optic neuropathies [0.03%]
靶向抑制SARM1在创伤性青光眼和自身免疫性脑脊髓炎视神经病变的治疗中效果不同
Pingting Liu,Wei Chen,Haowen Jiang et al.
Pingting Liu et al.
Optic neuropathy is a group of optic nerve (ON) diseases with progressive degeneration of ON and retinal ganglion cells (RGCs). The lack of neuroprotective treatments is a central challenge for this leading cause of irreversible blindness. ...
Expanding DdCBE-mediated targeting scope to aC motif preference in rat [0.03%]
通过DdCBE介导的靶向范围扩展至大鼠aC基序偏好性
Xiaolong Qi,Lei Tan,Xu Zhang et al.
Xiaolong Qi et al.
An animal model harboring pathogenic mitochondrial DNA (mtDNA) mutations is important to understand the biological links between mtDNA variation and mitochondrial diseases. DdCBE, a DddA-derived cytosine base editor, has been utilized in ze...
Can the RBD mutation R346X provide an additional fitness to the "variant soup," including offspring of BQ and XBB of SARS-CoV-2 Omicron for the antibody resistance? [0.03%]
RBD突变R346X能否为包括SARS-CoV-2奥密克戎BA.1的BQ和XBB后代等在内的“变异体汤”提供抗体抵抗优势？
Srijan Chatterjee,Manojit Bhattacharya,Kuldeep Dhama et al.
Srijan Chatterjee et al.