Inhibition of adenovirus replication by CRISPR-Cas9-mediated targeting of the viral E1A gene
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DNA-targeting CRISPR-Cas systems are able to cleave dsDNA in mammalian cells. Accordingly, they have been employed to target the genomes of dsDNA viruses, mostly when present in cells in a non-replicative state with low copy numbers. However, the sheer amount ... ...
