Design of bifunctional RNA-binding compounds that can modulate siRNA hydrophobicity for deep penetration and gene silencing in the retina [0.03%]
一类可调节siRNA疏水性的双功能RNA结合化合物的设计，能深入视网膜并实现基因沉默功能
Qi Mao,Yanan Quan,Siyi Chen et al.
Qi Mao et al.
Small interfering RNA (siRNA) could be a promising new modality to block the neovascularization in retinal diseases. For ocular siRNA delivery, hydrophobic modification is essential to increase the siRNA membrane compatibility, self-deliver...
CyDENT: A tale of CRISPR-free strand-specific base editor for nuclear and organellar genomes [0.03%]
一种无需CRISPR的核基因组和细胞器基因组特异性碱基编辑系统
Mahnoor Jamil,Ambreen Zahra,Rizwana Maqbool et al.
Mahnoor Jamil et al.
Switching off hypertrophy: Conditional siRNA as a precision tool for heart failure therapy [0.03%]
转换 hypertrophy: 条件性 siRNA 作为心力衰竭治疗的精准工具
Takashi Ikenouchi,Eugenio Cingolani
Takashi Ikenouchi
Multivalent aptamer engineered and functionalized NK cells for enhanced adoptive immunotherapy in CD30-positive malignant lymphoma [0.03%]
工程化多功能适配子功能NK细胞增强CD30阳性恶性淋巴瘤过继免疫治疗效果
Fang Tan,Rui Wei,Jiqing Su et al.
Fang Tan et al.
Adoptive cell therapy is a notable achievement in the treatment of various hematological malignancies. Among these cell-based therapies, chimeric antigen receptor natural killer (CAR-NK) cells have received increasing attention because, unl...
Targeting HypoxamiRs: A new perspective on overcoming treatment resistant glioblastoma [0.03%]
靶向缺氧微小核糖核酸：克服治疗抵抗性胶质母细胞瘤的新视角
Rajat Choudhary,Debyashreeta Barik,V Badireenath Konkimalla
Rajat Choudhary
MicroRNA-21 is a potential therapeutic agent targeting Tgfbi and mitigating high-fat-diet-induced liver disease and cancer [0.03%]
microRNA-21是一种潜在的治疗剂，可靶向TGFBI并减轻高脂饮食引起的肝病和癌症
Urmila Jagtap,Anan Quan,Yuho Ono et al.
Urmila Jagtap et al.
Liver disease, including hepatocellular carcinoma (HCC), is a major global health concern, claiming approximately 2 million lives worldwide annually, yet curative treatments remain elusive. In this study, we aimed to investigate the role of...
Co-transcriptional modifications of 2'-hydroxyls on synthetic mRNA enhance ribonuclease resistance and lipid nanoparticle thermostability [0.03%]
合成mRNA的共转录修饰提高其耐 RNase活性和脂质纳米颗粒热稳定性
Kohki Yamada,Yun-Chieh Sung,Tsung-Ying Lee et al.
Kohki Yamada et al.
The innate fragility of messenger RNA (mRNA) stems from 2'-hydroxyls on the ribose that are responsible for making mRNA sensitive to enzymatic and thermal degradation, posing formidable challenges in efficacy, in vivo stability, global-scal...
JAK2V617F+ single-stranded DNA modulates exosome complex activity and DNA-sensing pathways in myeloproliferative neoplasms [0.03%]
JAK2V617F阳性单链DNA调节髓系肿瘤中的外泌体复合物活性和DNA感受通路
Esra Nur Demirtaş,Ipek Naz Kadioglu,Selçuk Sözer
Esra Nur Demirtaş
Philadelphia chromosome-negative myeloproliferative neoplasms (Ph-MPNs) are characterized by excessive myeloid cell proliferation due to mutations in hematopoietic stem/progenitor cells, most notably JAK2V617F mutation. This mutation leads ...
Integrated multi-omics profiling uncovers miRNA-guided regulatory networks after spinal cord injury in rats [0.03%]
整合多组学分析揭示脊髓损伤后miRNA指导的调控网络（大鼠）
Ruslan A Klassen,Sarka Chytilova,Ivan Arzhanov et al.
Ruslan A Klassen et al.
Spinal cord injury (SCI) is a debilitating condition with no effective treatment. The injury triggers a complex cascade of molecular and cellular events that drive both damage and repair processes. To explore these mechanisms, we performed ...
Innovative aptamer approaches in glial tumor diagnostics and therapy: Progress and future directions [0.03%]
胶质瘤诊断和治疗中的创新适配子方法：进展与未来方向
Natalia A Luzan,Tatiana N Zamay,Penghui Zhang et al.
Natalia A Luzan et al.
Glial tumors, particularly glioblastomas, remain among the most challenging cancers to diagnose and treat due to their heterogeneity, infiltrative nature, and the protective blood-brain barrier that impedes drug delivery. Aptamers-short, si...